DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and YOR1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_011797.3	Gene:	YOR1 / 853198	SGDID:	S000003513	Length:	1477	Species:	Saccharomyces cerevisiae

Alignment Length:	1416	Identity:	444/1416 - (31%)
Similarity:	696/1416 - (49%)	Gaps:	170/1416 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKKL----QTN------PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLG 55
            :.:||:    ||:      |.....|.|.:.|.:.||||..|.|:|::|.||:........|||.
Yeast    90 LHSKKIPEVPQTDDERKIYPLFHTNIISNMFFWWVLPILRVGYKRTIQPNDLFKMDPRMSIETLY 154

  Fly    56 DKF--------------------FATWQSEVRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGV 100
            |.|                    .|| :.||......||.  :::|.:|..|..|.|:| ||..:
Yeast   155 DDFEKNMIYYFEKTRKKYRKRHPEAT-EEEVMENAKLPKH--TVLRALLFTFKKQYFMS-IVFAI 215

  Fly   101 LELGTRATLPLILGALIAEFTRN---------GNGDGLWAQIYGLTLILSILFSVLMFHPLMMGL 156
            |...|....|:|...|| ||...         ..|.|     |.:...|.:..:.|.|:......
Yeast   216 LANCTSGFNPMITKRLI-EFVEEKAIFHSMHVNKGIG-----YAIGACLMMFVNGLTFNHFFHTS 274

  Fly   157 MHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLI 221
            ....::.:..::.|..:|....|..|......|:|.:.::.||.|.:.||....||...|..|.|
Yeast   275 QLTGVQAKSILTKAAMKKMFNASNYARHCFPNGKVTSFVTTDLARIEFALSFQPFLAGFPAILAI 339

  Fly   222 SSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMY 286
            ....|...:|..:|.||.|......|..|..:|....|....:.||.||.||.|:::.|::||.|
Yeast   340 CIVLLIVNLGPIALVGIGIFFGGFFISLFAFKLILGFRIAANIFTDARVTMMREVLNNIKMIKYY 404

  Fly   287 TWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFVSLLGF--VLMGGELTAERAF 349
            |||..:.:.|:.:|..|:|.:||:...|..|::..::|..||..|:.|..  |..||.... ..|
Yeast   405 TWEDAYEKNIQDIRTKEISKVRKMQLSRNFLIAMAMSLPSIASLVTFLAMYKVNKGGRQPG-NIF 468

  Fly   350 SVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEP---- 410
            :..:.:.:|...:. |.|..:....:|::.|.|::..:...|.:        .|::.|.:|
Yeast   469 ASLSLFQVLSLQMF-FLPIAIGTGIDMIIGLGRLQSLLEAPEDD--------PNQMIEMKPSPGF 524

  Fly   411 ----LVKLQSFQARWN----HDHVEPV-------------------------------LEN---- 432
                .:|:......|.    :|.:|..                               |:|
Yeast   525 DPKLALKMTHCSFEWEDYELNDAIEEAKGEAKDEGKKNKKKRKDTWGKPSASTNKAKRLDNMLKD 589

  Fly   433 -----------------INISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYA 480
                             :|..:...:.:.:.||:|:|||||:.|:.|.:....||::|.||:...
Yeast   590 RDGPEDLEKTSFRGFKDLNFDIKKGEFIMITGPIGTGKSSLLNAMAGSMRKTDGKVEVNGDLLMC 654

  Fly   481 SQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARI 544
            .. ||:.||||||||:||.|.:|.:|..|:|.|:|:.|.::| .||.|.:||||.:|||||:|||
Yeast   655 GY-PWIQNASVRDNIIFGSPFNKEKYDEVVRVCSLKADLDILPAGDMTEIGERGITLSGGQKARI 718

  Fly   545 SLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDK 609
            :|||:||::.|.||.||.|||||:.||:|:.:||:.|.|.:|..||.||||..:|.|..::::..
Yeast   719 NLARSVYKKKDIYLFDDVLSAVDSRVGKHIMDECLTGMLANKTRILATHQLSLIERASRVIVLGT 783

  Fly   610 GKISAVGTYEEMLKSGQDFGKLLATEAQ--EMGDSNQEQVNA-EGDSRNDKSTYSRQSSRVSRVS 671
            .....:||.:|:....|....||...:|  |..|..||.|.| |......:|.....:....:.:
Yeast   784 DGQVDIGTVDELKARNQTLINLLQFSSQNSEKEDEEQEAVVAGELGQLKYESEVKELTELKKKAT 848

  Fly   672 VTSVDSSTESILDNERQPAQESRSQGKIGLGIYGKYFSAGSG-W--LMVILVAFFCLGTQILASG 733
            ..|..:::..|:.:....::|.|:...|.|.||.:|..|..| |  :.:.|.|...:||...:..
Yeast   849 EMSQTANSGKIVADGHTSSKEERAVNSISLKIYREYIKAAVGKWGFIALPLYAILVVGTTFCSLF 913

  Fly   734 GDYFLSYWVKNNDSSSSTDIY--IFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRT 796
            ...:||||.:|...:.....|  ::|....|..||...:..:..:|.:.:|..|:....:.:..|
Yeast   914 SSVWLSYWTENKFKNRPPSFYMGLYSFFVFAAFIFMNGQFTILCAMGIMASKWLNLRAVKRILHT 978

  Fly   797 ALYFFHANPSGRILNRFAMDLGQVD-EILPAVMLDCIQIFLTISGIIGVLCITN-PWYLINTITM 859
            .:.:....|.|||||||..|...:| |:..::.|...| |..|.|:. |:||.. ||:.|....:
Yeast   979 PMSYIDTTPLGRILNRFTKDTDSLDNELTESLRLMTSQ-FANIVGVC-VMCIVYLPWFAIAIPFL 1041

  Fly   860 FLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQD-LLTKEYDNYQDIHS 923
            .:.|..:...|.|:.|::|||||:.||.:|::.:..|.|:.||:|..:|: .|.|.......::.
Yeast  1042 LVIFVLIADHYQSSGREIKRLEAVQRSFVYNNLNEVLGGMDTIKAYRSQERFLAKSDFLINKMNE 1106

  Fly   924 SGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQS 988
            :||...: ..|..|.:||:..:|:.:.:||:........:...:|:::|..:.:.|.:...:|..
Yeast  1107 AGYLVVV-LQRWVGIFLDMVAIAFALIITLLCVTRAFPISAASVGVLLTYVLQLPGLLNTILRAM 1170

  Fly   989 AELENSMTSVERVLEY-RHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKS 1052
            .:.||.|.|.||::.| ..|..|..:..| :..||.:||..|.|..|.:...|.|.  ...|||:
Yeast  1171 TQTENDMNSAERLVTYATELPLEASYRKP-EMTPPESWPSMGEIIFENVDFAYRPG--LPIVLKN 1232

  Fly  1053 LNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNE---GSLVIDNTDILGIGLHDLRSKISIIPQ 1114
            ||..|...|||||.||||||||::::||:||  ||   |.::|||.||..:||.|||.|::||||
Yeast  1233 LNLNIKSGEKIGICGRTGAGKSTIMSALYRL--NELTAGKILIDNVDISQLGLFDLRRKLAIIPQ 1295

  Fly  1115 EPVLFSGTLRCNLDPFEQYADEKLWEALEE--VHLKDEVSEL------PNG---------LESVV 1162
            :||||.||:|.|||||.:..|::||:||..  ...||::.|:      .||         |:..|
Yeast  1296 DPVLFRGTIRKNLDPFNERTDDELWDALVRGGAIAKDDLPEVKLQKPDENGTHGKMHKFHLDQAV 1360

  Fly  1163 AEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRL 1227
            .|.|||:|:|:|||:.|.||::|:::||::||||::||.:||..||:.|..:|.|||:|.|||||
Yeast  1361 EEEGSNFSLGERQLLALTRALVRQSKILILDEATSSVDYETDGKIQTRIVEEFGDCTILCIAHRL 1425

  Fly  1228 NTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG--RSSFEH 1276
            .||::.||::||:.|.:.||.:|:.|.:|. ..:|..|..::|  .:.||:
Yeast  1426 KTIVNYDRILVLEKGEVAEFDTPWTLFSQE-DSIFRSMCSRSGIVENDFEN 1475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	436/1388 (31%)
		ABC_membrane	92..362	CDD:294371	76/280 (27%)
		ABCC_MRP_domain1	412..611	CDD:213217	89/255 (35%)
		ABC_membrane	718..981	CDD:294371	72/267 (27%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	115/240 (48%)
YOR1	NP_011797.3	MRP_assoc_pro	92..1468	CDD:188098	441/1405 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I2258
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.710