Protein Alignment CG9270 and YCF1

DIOPT Version :9

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: NP_010419.3
• Gene: YCF1 / 851713
• SGDID: S000002542
• Length: 1515
• Species: Saccharomyces cerevisiae
• Alignment Length: 1351
• Identity: 472/1351 - (34%)
• Similarity: 732/1351 - (54%)
• Gaps: 139/1351 - (10%)

  Fly     9 NPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSP 73
            ||.:||.|||.:.|.:...::..|.:|.|...|||...:...:|.|..|....|::|::.
Yeast   210 NPYDSANIFSRITFSWMSGLMKTGYEKYLVEADLYKLPRNFSSEELSQKLEKNWENELKQ----- 269

  Fly    74 KKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGL--WAQIYG- 135
            |..||:...|.:.||.::.|:.....:.:: ...|.|.:|..|| :|..:.|.:..  .:.:.|
Yeast   270 KSNPSLSWAICRTFGSKMLLAAFFKAIHDV-LAFTQPQLLRILI-KFVTDYNSERQDDHSSLQGF 332

  Fly   136 -------LTLILSILFSVLMF----------HPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTAL 183
                   |.::...|.:..||          |...:.:.:..|.::.|::..||:|:|.||..|.
Yeast   333 ENNHPQKLPIVRGFLIAFAMFLVGFTQTSVLHQYFLNVFNTGMYIKSALTALIYQKSLVLSNEAS 397

  Fly   184 GDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQ 248
            |.::||.:|||:|.|:.:........:.:|.||.:::|..|.||:.:|.:...|::||::.:|:.
Yeast   398 GLSSTGDIVNLMSVDVQKLQDLTQWLNLIWSGPFQIIICLYSLYKLLGNSMWVGVIILVIMMPLN 462

  Fly   249 TFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRS-EMSSIRKVN- 311
            :||.|:..:|:.......|:|.|:::||::.|:.:|:|.||||:...:|.:|.: |:.::.|:.
Yeast   463 SFLMRIQKKLQKSQMKYKDERTRVISEILNNIKSLKLYAWEKPYREKLEEVRNNKELKNLTKLGC 527

  Fly   312 YIRGTLLSFEITLSRIAIFVSLLGFVLM----GGELTAERAFSVTAFYNILRRTVCKFFPSGMSQ 372
            |:..|...|.|    :...||...|.:.    ...||.:..|.....:|:|...: ...|..::.
Yeast   528 YMAVTSFQFNI----VPFLVSCCTFAVFVYTEDRALTTDLVFPALTLFNLLSFPL-MIIPMVLNS 587

  Fly   373 FAEMMVTLRRIKGFMMRSETE----------------ALYLKGGQTNKLFEGEPLVKLQSFQARW 421
            |.|..|::.|:..|....|.:                |:.: |.....|::.:|..|:
Yeast   588 FIEASVSIGRLFTFFTNEELQPDSVQRLPKVKNIGDVAINI-GDDATFLWQRKPEYKV------- 644

  Fly   422 NHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWL 486
                   .|:|||.......|..::|.|||||::|:..:||:|....|...|.|.::|.||.||:
Yeast   645 -------ALKNINFQAKKGNLTCIVGKVGSGKTALLSCMLGDLFRVKGFATVHGSVAYVSQVPWI 702

  Fly   487 FNASVRDNILFGLPMDKHRYRNVIRNCALERDFE-LLHGDRTFVGERGASLSGGQRARISLARAV 550
            .|.:|::|||||...|...|...|:.|||..|.. |:.||:|.|||:|.||||||:||:||||||
Yeast   703 MNGTVKENILFGHRYDAEFYEKTIKACALTIDLAILMDGDKTLVGEKGISLSGGQKARLSLARAV 767

  Fly   551 YRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKIS 613
            |.:||||||||||:|||.||.|||.|..:  .|.|..|..:|.|:::..|..||.|.::|.|:|:
Yeast   768 YARADTYLLDDPLAAVDEHVARHLIEHVLGPNGLLHTKTKVLATNKVSALSIADSIALLDNGEIT 832

  Fly   614 AVGTYEEMLKSG--------QDFGKLLATEAQEMGDSNQEQVN-----AEGD-----SRNDKSTY 660
            ..|||:|:.|..        .::||....::.|.|||::..|.     .||:     ..||....
Yeast   833 QQGTYDEITKDADSPLWKLLNNYGKKNNGKSNEFGDSSESSVRESSIPVEGELEQLQKLNDLDFG 897

  Fly   661 SRQS---SRVSRVSVTSVDSSTESILDNERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAF 722
            :..:   .|.|..::.|:|..     |:|....:|.|.|||:...||.:|..|.:...:.:.:.|
Yeast   898 NSDAISLRRASDATLGSIDFG-----DDENIAKREHREQGKVKWNIYLEYAKACNPKSVCVFILF 957

  Fly   723 FCLGTQILASGGDYFLSYWVKNNDSSSSTD-------IYIFSGINAALVIFALLRTL-LFFSMAM 779
            ..: :..|:..|:.:|.:|.:.|....|..       ||...||.:||.  .|::|: |:....:
Yeast   958 IVI-SMFLSVMGNVWLKHWSEVNSRYGSNPNAARYLAIYFALGIGSALA--TLIQTIVLWVFCTI 1019

  Fly   780 HSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEIL----PAVMLDCIQIFLTISG 840
            |:|..|||.|...|.|..:.||...|.|||||||:.|:.:||.:|    ....::.:::..||:
Yeast  1020 HASKYLHNLMTNSVLRAPMTFFETTPIGRILNRFSNDIYKVDALLGRTFSQFFVNAVKVTFTIT- 1083

  Fly   841 IIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAM 905
               |:|.|...::...|.:.:.:.:.:.:||.|||:|:||::|.|||:||||..||.||:|:|..
Yeast  1084 ---VICATTWQFIFIIIPLSVFYIYYQQYYLRTSRELRRLDSITRSPIYSHFQETLGGLATVRGY 1145

  Fly   906 EAQDLLTKEYDNYQ----DIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYF--NPPVDNP 964
            ..|    |.:.:..    |.:.|.:|..::.||...|.|:|.....::....:|.|  .......
Yeast  1146 SQQ----KRFSHINQCRIDNNMSAFYPSINANRWLAYRLELIGSIIILGAATLSVFRLKQGTLTA 1206

  Fly   965 GQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESP---DDKKPPMNWP 1026
            |.:||.::.|:.:|.|:.|.:|.:.|:|.::.||||:.||..|::    |:|   :..:||..||
Yeast  1207 GMVGLSLSYALQITQTLNWIVRMTVEVETNIVSVERIKEYADLKS----EAPLIVEGHRPPKEWP 1267

  Fly  1027 QEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR-LSYNEGSL 1090
            .:|.|.....|.||.|:  .|.|||.:|..|.|.||:|||||||||||||..|||| :..:||::
Yeast  1268 SQGDIKFNNYSTRYRPE--LDLVLKHINIHIKPNEKVGIVGRTGAGKSSLTLALFRMIEASEGNI 1330

  Fly  1091 VIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELP 1155
            ||||..|..|||:|||.|:|||||:..:|.||:|.|:||..||.||.:|.|||..|||:.|..:.
Yeast  1331 VIDNIAINEIGLYDLRHKLSIIPQDSQVFEGTVRENIDPINQYTDEAIWRALELSHLKEHVLSMS 1395

  Fly  1156 N-GLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCT 1219
            | ||::.:.|||.|.|||||||:|||||:|..::|||:|||||.||.:||.::|.|||..|:|.|
Yeast  1396 NDGLDAQLTEGGGNLSVGQRQLLCLARAMLVPSKILVLDEATAAVDVETDKVVQETIRTAFKDRT 1460

  Fly  1220 VLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            :||||||||||:||||::|||.|.:.||.||.:||:.:.| :||.:.::.|
Yeast  1461 ILTIAHRLNTIMDSDRIIVLDNGKVAEFDSPGQLLSDNKS-LFYSLCMEAG 1510

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	468/1336 (35%)
		ABC_membrane	92..362	CDD:294371	75/295 (25%)
		ABCC_MRP_domain1	412..611	CDD:213217	90/201 (45%)
		ABC_membrane	718..981	CDD:294371	83/280 (30%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	129/222 (58%)
YCF1	NP_010419.3	MRP_assoc_pro	27..1511	CDD:188098	472/1351 (35%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720