DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and BPT1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_013086.1	Gene:	BPT1 / 850645	SGDID:	S000003938	Length:	1559	Species:	Saccharomyces cerevisiae

Alignment Length:	1359	Identity:	433/1359 - (31%)
Similarity:	705/1359 - (51%)	Gaps:	165/1359 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 KKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEPSIIRVILKVFG---------- 88
            ||..:|..|.....:...:::..:|.|.|:.|      ......|:.|.|.|.||
Yeast   241 KKIKDPNQLPLPPVDLNIKSISKEFKANWELE------KWLNRNSLWRAIWKSFGRTISVAMLYE 299

  Fly    89 -------------WQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLIL 140
                         .::|:.|     |...|.:..|.:.|..||                 |||.:
Yeast   300 TTSDLLSVVQPQFLRIFIDG-----LNPETSSKYPPLNGVFIA-----------------LTLFV 342

  Fly   141 SILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRA 205
            ..:.||.:.:...:|:....:.:|.::::.:|:|:|||:.....:.:||.::||:|.|:.|..|.
Yeast   343 ISVVSVFLTNQFYIGIFEAGLGIRGSLASLVYQKSLRLTLAERNEKSTGDILNLMSVDVLRIQRF 407

  Fly   206 LIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRV 270
            ..:...:...|:::::....||..:|.|.:.|:|.:.:.:||..||||...:|........|.|:
Yeast   408 FENAQTIIGAPIQIIVVLTSLYWLLGKAVIGGLVTMAIMMPINAFLSRKVKKLSKTQMKYKDMRI 472

  Fly   271 RMMNEIISGIQVIKMYTWEKPFGRLIERLRRS-EMSSIRKVN------YIRGTLLSFEITLSRIA 328
            :.:.|:::.|:.||:|.||:|....:..:|.. |:.:.||:.      |.....:...:|.|...
Yeast   473 KTITELLNAIKSIKLYAWEEPMMARLNHVRNDMELKNFRKIGIVSNLIYFAWNCVPLMVTCSTFG 537

  Fly   329 IFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETE 393
            :| ||..    ...|:....|...:.:|||...:.. .||.::...|..|::.|:|.|::..|.:
Yeast   538 LF-SLFS----DSPLSPAIVFPSLSLFNILNSAIYS-VPSMINTIIETSVSMERLKSFLLSDEID 596

  Fly   394 ALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHV--------------EPVLENINISL------- 437
            ..:::....:......|.:::.:....|....|              |.::.:..|:|
Yeast   597 DSFIERIDPSADERALPAIEMNNITFLWKSKEVLTSSQSGDNLRTDEESIIGSSQIALKNIDHFE 661

  Fly   438 -SPPQLVAVIGPVGSGKSSLIQAILGELPGESG-------KLKVQ-GDISYASQEPWLFNASVRD 493
             ....||.|:|.||:|||:.::||||:||..||       ||.:: ..::|.|||.|:.|||||:
Yeast   662 AKRGDLVCVVGRVGAGKSTFLKAILGQLPCMSGSRDSIPPKLIIRSSSVAYCSQESWIMNASVRE 726

  Fly   494 NILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTY 557
            |||||...|:..|...|:.|.|..|.::| .||.|.|||:|.||||||:||:|||||||.:||.|
Yeast   727 NILFGHKFDQDYYDLTIKACQLLPDLKILPDGDETLVGEKGISLSGGQKARLSLARAVYSRADIY 791

  Fly   558 LLDDPLSAVDTHVGRHLFEECMRG---FLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYE 619
            ||||.|||||..|.:::.|..:.|   .|::|.:||.|:.:..|:|:.:|..::.|:|...|.||
Yeast   792 LLDDILSAVDAEVSKNIIEYVLIGKTALLKNKTIILTTNTVSILKHSQMIYALENGEIVEQGNYE 856

  Fly   620 EML---KSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRND-------KSTYSRQSSRV---SRVS 671
            :::   .:.....|||......:.:.|:..|..|..|.::       |.|.|.....|   |.:.
Yeast   857 DVMNRKNNTSKLKKLLEEFDSPIDNGNESDVQTEHRSESEVDEPLQLKVTESETEDEVVTESELE 921

  Fly   672 VTSVDSSTESI------------LDNERQPAQ--ESRSQGKIGLGIYGKYFSAGSGWLMVILVAF 722
            :...:|...|:            ||:.::.||  |....|::...||..|..| .|.|.|:|...
Yeast   922 LIKANSRRASLATLRPRPFVGAQLDSVKKTAQKAEKTEVGRVKTKIYLAYIKA-CGVLGVVLFFL 985

  Fly   723 FCLGTQILASGGDYFLSYWVKNNDSSSSTD-IYIFSG----INAALVIFALLRT-LLFFSMAMHS 781
            |.:.|::.....:::|.||.::|:.:.|.: :::|.|    |..|...|..||: ::....::..
Yeast   986 FMILTRVFDLAENFWLKYWSESNEKNGSNERVWMFVGVYSLIGVASAAFNNLRSIMMLLYCSIRG 1050

  Fly   782 STQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLC 846
            |.:||.:|.:.|.|:.:.||...|.|||:|||:.|:..||..|..:.....:..||....:.::.
Yeast  1051 SKKLHESMAKSVIRSPMTFFETTPVGRIINRFSSDMDAVDSNLQYIFSFFFKSILTYLVTVILVG 1115

  Fly   847 ITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLL 911
            ...||:|:..:.:.:.:.:.:|||:..||:||||.:|:.||:.|..|.:|||.|.|.|.:..:..
Yeast  1116 YNMPWFLVFNMFLVVIYIYYQTFYIVLSRELKRLISISYSPIMSLMSESLNGYSIIDAYDHFERF 1180

  Fly   912 TKEYDNYQDI--HSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVD---NPGQIGLVI 971
            .  |.||:.|  :....:.|.||||.....|.......|::..:::.......   :.|.:||::
Yeast  1181 I--YLNYEKIQYNVDFVFNFRSTNRWLSVRLQTIGATIVLATAILALATMNTKRQLSSGMVGLLM 1243

  Fly   972 TQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQL 1036
            :.::.:||::.|.:|.:..:|.::.||||::||..|..|.:..:| :|:|..|||.:|.|..:..
Yeast  1244 SYSLEVTGSLTWIVRTTVTIETNIVSVERIVEYCELPPEAQSINP-EKRPDENWPSKGGIEFKNY 1307

  Fly  1037 SLRY--NPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR-LSYNEGSLVIDNTDIL 1098
            |.:|  |.||    ||.::|..|.|.||:|||||||||||:|..|||| |...||.::||..||.
Yeast  1308 STKYRENLDP----VLNNINVKIEPCEKVGIVGRTGAGKSTLSLALFRILEPTEGKIIIDGIDIS 1368

  Fly  1099 GIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSEL----PNG-- 1157
            .|||.||||.::||||:...|.||::.|||||.:|::::|..|:|:.|||..:.::    |.|
Yeast  1369 DIGLFDLRSHLAIIPQDAQAFEGTVKTNLDPFNRYSEDELKRAVEQAHLKPHLEKMLHSKPRGDD 1433

  Fly  1158 -----------LESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTI 1211
                       |:..:.|.|||.|||||||:|||||:|..::|||:|||||:||.:||.:||.||
Yeast  1434 SNEEDGNVNDILDVKINENGSNLSVGQRQLLCLARALLNRSKILVLDEATASVDMETDKIIQDTI 1498

  Fly  1212 RRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            ||:|:|.|:||||||::|::|||:::|||.|::.||.||.:||:...| :||.:..:.|
Yeast  1499 RREFKDRTILTIAHRIDTVLDSDKIIVLDQGSVREFDSPSKLLSDKTS-IFYSLCEKGG 1556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	429/1344 (32%)
		ABC_membrane	92..362	CDD:294371	67/276 (24%)
		ABCC_MRP_domain1	412..611	CDD:213217	91/232 (39%)
		ABC_membrane	718..981	CDD:294371	75/273 (27%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	120/240 (50%)
BPT1	NP_013086.1	MRP_assoc_pro	222..1556	CDD:188098	432/1357 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344627
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650