DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001031116.1	Gene:	ABCC1 / 839920	AraportID:	AT1G30400	Length:	1622	Species:	Arabidopsis thaliana

Alignment Length:	1313	Identity:	465/1313 - (35%)
Similarity:	736/1313 - (56%)	Gaps:	81/1313 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPK 74
            |...|.:|.::.|.:..|::..|.|:.|...|:::.....|.|||...|..:|..|:.      |
plant   227 PERHANLFDSIFFSWLNPLMTLGSKRPLTEKDVWHLDTWDKTETLMRSFQKSWDKELE------K 285

  Fly    75 KEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATL---PLILGALIAEFTRNGNGDGLW-AQIYG 135
            .:|.::|.:....|.:.:..|.    .::|...:.   ||:|..|:.....|   :..| ..||.
plant   286 PKPWLLRALNNSLGGRFWWGGF----WKIGNDCSQFVGPLLLNELLKSMQLN---EPAWIGYIYA 343

  Fly   136 LTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLG 200
            :::.:.::..||........:|.:..::|.|:..|::||:|||:........||::.||::.|..
plant   344 ISIFVGVVLGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRKKFQTGKITNLMTTDAE 408

  Fly   201 RFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALR 265
            ...:.....|.:|..|..::::...||||:||||:.|.:.|:|..||||.:...|.:|..:...|
plant   409 SLQQICQSLHTMWSAPFRIIVALVLLYQQLGVASIIGALFLVLMFPIQTVIISKTQKLTKEGLQR 473

  Fly   266 TDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEI-TLSRIAI 329
            ||:|:.:|||:::.:..:|.|.||..|...::.:|..|:|..||..    .|.:|.: .|:.|.:
plant   474 TDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRKAQ----LLSAFNMFILNSIPV 534

  Fly   330 FVSLLG---FVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSE 391
            .|:::.   |.|:||:||..|||:..:.:::||..:. ..|:.::|.....|:|.|::..:...|
plant   535 LVTVVSFGVFSLLGGDLTPARAFTSLSLFSVLRFPLF-MLPNIITQMVNANVSLNRLEEVLSTEE 598

  Fly   392 TEALYLKGGQTNKLFE-GEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSS 455
            ...|      .|...| |:|.:.:::....|:.....|.|.|||:.:....||||:|..|.||:|
plant   599 RVLL------PNPPIEPGQPAISIRNGYFSWDSKADRPTLSNINLDIPLGSLVAVVGSTGEGKTS 657

  Fly   456 LIQAILGELPGES-GKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDF 519
            ||.|:|||||..| ..:.::|.::|..|..|:|||:||||||||.|.|:.:|..||...||:.|.
plant   658 LISAMLGELPARSDATVTLRGSVAYVPQVSWIFNATVRDNILFGAPFDQEKYERVIDVTALQHDL 722

  Fly   520 ELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFL 583
            ||| .||.|.:||||.::||||:.|:|:|||||..:|..:|||||||:|.|||:.:||:|::..|
plant   723 ELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSNSDVCILDDPLSALDAHVGQQVFEKCIKREL 787

  Fly   584 RDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVN 648
            .....:|||:||.||...|.|:::.:|.:...|||||:..||..|.:|: ..|.::.|.::|...
plant   788 GQTTRVLVTNQLHFLSQVDKILLVHEGTVKEEGTYEELCHSGPLFQRLM-ENAGKVEDYSEENGE 851

  Fly   649 AEGDSRNDKSTYSRQSSRVSRVSVTSVDSST-ESILDNERQPAQESRSQGKIGLGIYGKYFSA-G 711
            ||.|..:.|...:..::.:.:..:.:.:|.. .|:|     ..:|.|..|.:...:..:|.:| |
plant   852 AEVDQTSVKPVENGNANNLQKDGIETKNSKEGNSVL-----VKREERETGVVSWKVLERYQNALG 911

  Fly   712 SGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTDIYIFSGINAALVIF-----ALLRT 771
            ..|::::||..:.| ||:.......:||.|  .:..:..|...:|..|..||:.|     .|:.:
plant   912 GAWVVMMLVICYVL-TQVFRVSSSTWLSEW--TDSGTPKTHGPLFYNIVYALLSFGQVSVTLINS 973

  Fly   772 LLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCI---- 832
            ......:::::.::|:.|...:.|..:.||..||.|||:||||.|:|.:|..: ||.::..
plant   974 YWLIMSSLYAAKKMHDAMLGSILRAPMVFFQTNPLGRIINRFAKDMGDIDRTV-AVFVNMFMGSI 1037

  Fly   833 -QIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATL 896
             |:..|:. :||::...:.|.::..:.:|...:.   :|.:|||::||:::..|||:|:.|...|
plant  1038 AQLLSTVI-LIGIVSTLSLWAIMPLLVVFYGAYL---YYQNTSREIKRMDSTTRSPVYAQFGEAL 1098

  Fly   897 NGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDL---FCVAYVISVTLMSYFN 958
            ||||:|||.:|.|.:.:......|.:.......::.||..|..|::   ..|....|:.:|.  |
plant  1099 NGLSSIRAYKAYDRMAEINGRSMDNNIRFTLVNMAANRWLGIRLEVLGGLMVWLTASLAVMQ--N 1161

  Fly   959 PPVDN----PGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESP--- 1016
            ....|    ...:||:::.|:|:|.::...:|.::..|||:.|||||..|..:.:    |:|
plant  1162 GKAANQQAYASTMGLLLSYALSITSSLTAVLRLASLAENSLNSVERVGNYIEIPS----EAPLVI 1222

  Fly  1017 DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALF 1081
            ::.:||..||..|.|..|.:.|||.|:  ...||..::|:|.|.:|:|||||||||||||:||||
plant  1223 ENNRPPPGWPSSGSIKFEDVVLRYRPE--LPPVLHGVSFLISPMDKVGIVGRTGAGKSSLLNALF 1285

  Fly  1082 RL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEV 1145
            |: ...:|.::||..||...||.|||..:.||||.|||||||:|.|||||.::.|..|||:||..
plant  1286 RIVELEKGRILIDECDIGRFGLMDLRKVLGIIPQAPVLFSGTVRFNLDPFSEHNDADLWESLERA 1350

  Fly  1146 HLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQST 1210
            ||||.:...|.||::.|.|.|.|:|||||||:.||||:||.::|||:|||||.||.:||.|||.|
plant  1351 HLKDTIRRNPLGLDAEVTEAGENFSVGQRQLLSLARALLRRSKILVLDEATAAVDVRTDVLIQKT 1415

  Fly  1211 IRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSSFE 1275
            ||.:|:.||:|.||||||||||.|:|:|||:|.:.||.||..||:...|. |..||..||.::.|
plant  1416 IREEFKSCTMLIIAHRLNTIIDCDKVLVLDSGKVQEFSSPENLLSNGESS-FSKMVQSTGTANAE 1479

  Fly  1276 HLLKLALEAHERR 1288
            :|..:.||....|
plant  1480 YLRSITLENKRTR 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	454/1280 (35%)
		ABC_membrane	92..362	CDD:294371	79/277 (29%)
		ABCC_MRP_domain1	412..611	CDD:213217	93/200 (47%)
		ABC_membrane	718..981	CDD:294371	76/279 (27%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	128/221 (58%)
ABCC1	NP_001031116.1	PLN03130	1..1622	CDD:215595	465/1313 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720