DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcb11

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_113948.1	Gene:	Abcb11 / 83569	RGDID:	619930	Length:	1321	Species:	Rattus norvegicus

Alignment Length:	1331	Identity:	297/1331 - (22%)
Similarity:	533/1331 - (40%)	Gaps:	284/1331 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    90 QLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMM 154
            |...:|.|.|::::.:.          :.:|:      |::|.: |:|:::...|.:.::  ::.
  Rat   121 QNMTNGTVCGLVDIESE----------MIKFS------GIYAGV-GMTVLILGYFQIRLW--VIT 166

  Fly   155 GLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIH--FHFL----- 212
            |...:....::     .:|:.:|:.......|:.|::.:..::|:.:.:.|:..  .|||
  Rat   167 GARQIRRMRKI-----YFRRIMRMEIGWFDCTSVGELNSRFADDIEKINDAIADQLAHFLQRMST 226

  Fly   213 ------------WLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALR 265
                        |  .|.|:|        :.|:.|.||...::.|.|..|           |.|.
  Rat   227 AMCGLLLGFYRGW--KLTLVI--------LAVSPLIGIGAAVIGLSIAKF-----------TELE 270

  Fly   266 TDQRVR---MMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRI 327
            .....:   :.:|::|.|:.:..:..|   .:.:||..:: :...::....:|.::.|.......
  Rat   271 LKAYAKAGSIADEVLSSIRTVAAFGGE---NKEVERYEKN-LVFAQRWGIWKGMVMGFFTGYMWC 331

  Fly   328 AIFVSLLGFVLMGGELTA-ERAFS-----------VTAFYNILRRTVC-KFFPSGMSQFAEMMVT 379
            .||.........|..|.. |..::           :.|..||...:.| :.|.:|.|....:..|
  Rat   332 LIFFCYALAFWYGSTLVLDEEEYTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAATNIFQT 396

  Fly   380 LRRIKGFMMRSETEALYLKGGQTNKL--FEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQL 442
            :.|         ...:....|...||  .:||  ::..:....:.......:|:|:::.:.|.:.
  Rat   397 IDR---------QPVIDCMSGDGYKLDRIKGE--IEFHNVTFHYPSRPDVKILDNLSMVIKPGET 450

  Fly   443 VAVIGPVGSGKSSLIQAILGELPGESGKLKVQG-------------DISYASQEPWLFNASVRDN 494
            .|::|..|:|||:.:|.|........|.:.:.|             .|....|||.||:.::.:|
  Rat   451 TALVGSSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAEN 515

  Fly   495 ILFG-----------LPMDKHRYRNVIRNCALERDFELLHGDRTFVGERGASLSGGQRARISLAR 548
            |.||           ...|.:.|..::   ||.:.|:      |.|||.|..:||||:.|:::||
  Rat   516 IRFGREDATMEDIVQAAKDANAYNFIM---ALPQQFD------TLVGEGGGQMSGGQKQRVAIAR 571

  Fly   549 AVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKIS 613
            |:.|.....|||...||:|......: :|.:........:|.|.|:|..:..||:|:..:.|...
  Rat   572 ALIRNPKILLLDMATSALDNESEARV-QEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAV 635

  Fly   614 AVGTYEEML-KSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVS-----RVSV 672
            ..||:||:| :.|..|  :|.| .|..||:..::.:..|....:..|..|..||.|     |.|:
  Rat   636 ERGTHEELLERKGVYF--MLVT-LQSQGDNAHKETSIMGKDATEGGTLERTFSRGSYRDSLRASI 697

  Fly   673 ------------------------TSVDSSTESILDNERQPAQESR------------SQGKIGL 701
                                    :..||....:|..|.:||...|            ..|.:..
  Rat   698 RQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYILVGSLSA 762

  Fly   702 GIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTDIYIFSGINAALVIF 766
            .|.|           .:...:..|.:|:|.:     .|...|....|....:.:|..|...:.||
  Rat   763 AING-----------AVTPIYSLLFSQLLGT-----FSLLDKEQQRSEIHSMCLFFVILGCVSIF 811

  Fly   767 A-LLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFH--ANPSGRILNRFAMDLGQVDEILPAVM 828
            . .|:...|.......:.:|....|:.:....:.:|.  .|..|.:..|.|.|..||.....:.:
  Rat   812 TQFLQGYTFAKSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQV 876

  Fly   829 LDCIQIFLTISGIIGVLCIT--NPWYLINTITMFLAFHFL----RTFYLS--TSRDLKRLEAIAR 885
            ...:..|   :.||..|.|.  ..|.|...||:|..|..|    :|..|:  .|:|.:.||...:
  Rat   877 GMMVNSF---TNIIAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQ 938

  Fly   886 SPMYSHFSATLNGLSTIRAMEAQDLLTKEYD-----NYQD-IHSSGYY----------TFLSTNR 934
            ..     |..|:.:.|:..:..:....|.::     :|:. :..:..|          .||:.:.
  Rat   939 IT-----SEALSNIRTVAGIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSA 998

  Fly   935 AFGY--YLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTS 997
            |:.|  ||    :||.                   ||..:....:..:|..          |.|:
  Rat   999 AYRYGGYL----IAYE-------------------GLGFSHVFRVVSSVAL----------SATA 1030

  Fly   998 VERVLEYRHLEAEGEFESPD-----DKKPPMN--------WPQ-EGLISAEQLSLRYNPDPKADR 1048
            |.|...|....|:.:..:..     |:|||:|        |.. :|.|........|...|.. :
  Rat  1031 VGRTFSYTPSYAKAKISAARFFQLLDRKPPINVYSEAGEKWDNFQGKIDFIDCKFTYPSRPDI-Q 1094

  Fly  1049 VLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISII 1112
            ||..|:..:.|.:.:..||.:|.|||:.|..|.|. ..::|:::||..|...:.:..|||.|.|:
  Rat  1095 VLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNIQFLRSNIGIV 1159

  Fly  1113 PQEPVLFSGTLRCNL---DPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQR 1174
            .||||||..::..|:   |..::.:.|:...|.::..|.|.|..||...|:.|...||..|.|::
  Rat  1160 SQEPVLFDCSIMDNIKYGDNTKEISVERAIAAAKQAQLHDFVMSLPEKYETNVGIQGSQLSRGEK 1224

  Fly  1175 QLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVL 1239
            |.:.:||||:|:.:||::||||:.:|.:::..:|:.:.:.....|.:.|||||:||.:||.:.|:
  Rat  1225 QRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTCIVIAHRLSTIQNSDIIAVV 1289

  Fly  1240 DAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            ..|.::|.|:..:|:.|..:  :|.:|: ||
  Rat  1290 SQGVVIEKGTHEKLMAQKGA--YYKLVI-TG 1317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	292/1316 (22%)
		ABC_membrane	92..362	CDD:294371	48/303 (16%)
		ABCC_MRP_domain1	412..611	CDD:213217	56/222 (25%)
		ABC_membrane	718..981	CDD:294371	56/291 (19%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	75/224 (33%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	286/1279 (22%)
Abcb11	NP_113948.1	Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	651..674		7/25 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000