DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC14

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_191829.1	Gene:	ABCC14 / 825444	AraportID:	AT3G62700	Length:	1539	Species:	Arabidopsis thaliana

Alignment Length:	1336	Identity:	464/1336 - (34%)
Similarity:	720/1336 - (53%)	Gaps:	140/1336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKE- 76
            ||...|...:.:..|:|.||.|..|....:.....||:||.|...|.:.|          ||.:
plant   252 SASFISKTFWLWMNPLLRKGYKSPLNLDQVPTLSPEHRAEKLATLFESKW----------PKPQE 306

  Fly    77 -------PSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFT---RNGNGDGLWA 131
                   .::||...|...:...|:.|.:.|:.:|     |:::.:.: :||   |:....|
plant   307 NSRNPVRTTLIRCFWKEIAFTAVLAIIRLSVIYVG-----PVLIQSFV-DFTSGKRSSPSQG--- 362

  Fly   132 QIYGLTLILSI--LFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNL 194
              |.|.|||.|  ...||..|........|.|.:|..:.||:|:|.|:|:.:|..:...||:||.
plant   363 --YYLVLILLIAKFVEVLSTHQFNFNSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQIVNY 425

  Fly   195 ISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIG---VASLYGIVILLLFLPIQTFLSRLTS 256
            ::.|..:....::..|.:||.||::..:...||..:|   |.::.|:..:.:|:.:.|   :..:
plant   426 MAVDAQQLSDMMLQLHAIWLMPLQVAAAIVLLYNTLGPSVVTTVIGLTGIFVFILLGT---KRNN 487

  Fly   257 RLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNY-IRGTLLSF 320
            |.:....:..|.|::..||:::.::|||...||..|...|.:.|..|...:.|..| |.|.:
plant   488 RYQFSLMMNRDSRMKATNEMLNYMRVIKFQAWEDHFNERILKFREMEFGWLSKFLYSIAGNI--- 549

  Fly   321 EITLSRIAIFVSLLGF---VLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRR 382
             |.|....:.:|.|.|   |.:|.:|.|...|:.|..:.||:..: :.||..|...::.|::|.|
plant   550 -IVLWSTPVLISALTFTTAVFLGVKLDAGTVFTTTTIFKILQEPI-RTFPQSMISLSQAMISLGR 612

  Fly   383 IKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIG 447
            :..:||..|.....::..|.   .:|...|:::.....|:.:..||.:||||..:...:|.|::|
plant   613 LDAYMMSRELSEETVERSQG---CDGNVAVEIKDGSFSWDDEDDEPAIENINFEVKKGELAAIVG 674

  Fly   448 PVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRN 512
            .||||||||:.::|||:...|||::|.|..:|.:|..|:.|.:|:|||||||||::.:|..|::.
plant   675 TVGSGKSSLLASVLGEMHKLSGKVRVCGTTAYVAQTSWIQNGTVQDNILFGLPMNRSKYNEVLKV 739

  Fly   513 CALERDFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFE 576
            |.||:|.:::. ||:|.:||||.:|||||:.||.||||||:::|.|||||..||||.|.|..:|:
plant   740 CCLEKDMQIMEFGDQTEIGERGINLSGGQKQRIQLARAVYQESDVYLLDDVFSAVDAHTGSDIFK 804

  Fly   577 ECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLAT-----EA 636
            :|:||.|:.|.::|||||:.||.:.|.|::|..|.|...|.|:|::.||.|||:|:|.     |.
plant   805 KCVRGALKGKTILLVTHQVDFLHNVDRILVMRDGMIVQSGKYDELVSSGLDFGELVAAHETSMEL 869

  Fly   637 QEMGDSN-------------QEQVNAEGDSRNDKS-----TYSRQSSRVSRVSVTSV-------- 675
            .|.|.::             |..::.| ..|..||     |.|.:|.||.|  .||:
plant   870 VEAGSASATAANVPMASPITQRSISIE-SPRQPKSPKVHRTTSMESPRVLR--TTSMESPRLSEL 931

  Fly   676 -DSSTESIL------DNERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASG 733
             |.|.:|.|      |..|...:|.|..|::...:|..|.:...||..:|||.||.:..|.....
plant   932 NDESIKSFLGSNIPEDGSRLIKEEEREVGQVSFQVYKLYSTEAYGWWGMILVVFFSVAWQASLMA 996

  Fly   734 GDYFLSY--WVKNNDSSSST---DIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGV 793
            .||:|:|  ..||..|..:|   .:|:.  |.|..::...||......:.:.::......:...:
plant   997 SDYWLAYETSAKNEVSFDATVFIRVYVI--IAAVSIVLVCLRAFYVTHLGLKTAQIFFKQILNSL 1059

  Fly   794 SRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTIT 858
            ....:.||...||||||:|.:.|...||..:|.::.....::.|:..|..|.|    .|...|:.
plant  1060 VHAPMSFFDTTPSGRILSRASTDQTNVDIFIPFMIGLVATMYTTLLSIFIVTC----QYAWPTVF 1120

  Fly   859 MFLAFHFL----RTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQ 919
            ..:...:|    |.:||::||:|.||::|.::|:..|||.::.|:.||||.:.|.:..:|  |.:
plant  1121 FIIPLGWLNIWYRGYYLASSRELTRLDSITKAPVIHHFSESIAGVMTIRAFKKQPMFRQE--NVK 1183

  Fly   920 --------DIHSSGYYTFLSTNRAFGYYLDL-----FCVAYVISVTLMSYFNPPVDNPGQIGLVI 971
                    |.|::|      :|...|:.|:|     .|::.:..|.|.|    .:..|..:||.:
plant  1184 RVNANLRMDFHNNG------SNEWLGFRLELIGSWVLCISALFMVMLPS----NIIKPENVGLSL 1238

  Fly   972 TQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQL 1036
            :..:|:.|.:.|.:..|..:||.|.||||:.::..:.||.::|..:.:.|| |||.:|.|..|.:
plant  1239 SYGLSLNGVLFWAIYLSCFIENKMVSVERIKQFTDIPAEAKWEIKESRPPP-NWPYKGNIRLEDV 1302

  Fly  1037 SLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGI 1100
            .:||.|:  ...|||.|...|...||||:|||||:|||:||..|||| ..:.|.::||..||..:
plant  1303 KVRYRPN--TPLVLKGLTIDIKGGEKIGVVGRTGSGKSTLIQVLFRLVEPSGGKIIIDGIDICTL 1365

  Fly  1101 GLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEG 1165
            |||||||:..|||||||||.||:|.|:||.|:|:||::|::||...|||.|:..|..|:|:||:.
plant  1366 GLHDLRSRFGIIPQEPVLFEGTVRSNIDPTEKYSDEEIWKSLERCQLKDVVASKPEKLDSLVADN 1430

  Fly  1166 GSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTI 1230
            |.|:|||||||:||.|.:|:.:|||.:|||||:||.||||:||..||..|.|||:::||||:.|:
plant  1431 GENWSVGQRQLLCLGRVMLKRSRILFLDEATASVDSQTDAMIQKIIREDFSDCTIISIAHRIPTV 1495

  Fly  1231 IDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMV 1266
            :|.|||:|:|||...|:.||..||.:  ..:|..:|
plant  1496 MDCDRVLVIDAGKAKEYDSPVRLLER--QSLFAALV 1529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	462/1325 (35%)
		ABC_membrane	92..362	CDD:294371	76/281 (27%)
		ABCC_MRP_domain1	412..611	CDD:213217	95/199 (48%)
		ABC_membrane	718..981	CDD:294371	76/284 (27%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	121/221 (55%)
ABCC14	NP_191829.1	MRP_assoc_pro	142..1534	CDD:188098	464/1336 (35%)
		ABC_membrane	329..593	CDD:294371	76/281 (27%)
		ABCC_MRP_domain1	639..838	CDD:213217	95/198 (48%)
		ABC_membrane	984..1252	CDD:294371	74/285 (26%)
		ABCC_MRP_domain2	1295..1515	CDD:213211	121/221 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720