DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC9

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_191575.2	Gene:	ABCC9 / 825186	AraportID:	AT3G60160	Length:	1506	Species:	Arabidopsis thaliana

Alignment Length:	1336	Identity:	432/1336 - (32%)
Similarity:	682/1336 - (51%)	Gaps:	144/1336 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYN----------------ALKEHK-AETLG 55
            ::|..:|.:|..:.|.:..|:...|.|:.||..|:.:                .||..| .|..|
plant   234 SSPYGNATLFQRITFSWINPLFSLGYKRPLEKDDVPDIDVKDSARFCSHAFDQKLKTTKEKEGPG 298

  Fly    56 DKFFATWQSEVRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEF 120
            :.||..                |::|.:     |:......|..|:...|....|.::...: ||
plant   299 NAFFYN----------------SVLRYV-----WRKAAINAVFAVVNASTAYIGPYLINDFV-EF 341

  Fly   121 TRNGNGDGLWAQIYGLTLILSILFSVLM----FHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRT 181
            ........|   .:|..|.|..|.:.::    ....:.|...|.:::|.|:.:.||:|.|.||..
plant   342 LSEKQSQSL---NHGYLLALGFLTAKIVETVTQRQWIFGARQLGLRLRAALISHIYQKGLVLSSQ 403

  Fly   182 ALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLP 246
            :....|:|:::|.:|.|:.|....:.:.:.:|:.|:::..:.|.|.:.:|:.:|..:|..|:.:.
plant   404 SRQSHTSGEIINYMSVDVQRITDFIWYVNNIWMLPIQIFSAIYILQKHLGLGALAALVTTLMVMA 468

  Fly   247 IQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVN 311
            ....|:||....:.......|.|::..:||:..::::|:..|:..|...::.||:.|...:.|
plant   469 CNYPLTRLQRNYQSDIMNAKDDRMKATSEILKNMKILKLQAWDNQFLNKVKTLRKKEYDCLWK-- 531

  Fly   312 YIRGTLLSFEITLSRIAIF--------VSLLGFV---LMGGELTAERAFSVTAFYNILRRTVCKF 365
                     .:.|.....|        :|::.||   |||.:|||....|..|.:.:|:..:..
plant   532 ---------SLRLQAFTTFILWGAPSLISVVTFVTCMLMGVKLTAGAVLSALATFQMLQSPIFG- 586

  Fly   366 FPSGMSQFAEMMVTLRRIKGFMMRSETE---ALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVE 427
            .|..:|...:..|:..||..::.:|||:   ..|.....|      |..|::::....|..:...
plant   587 LPDLLSALVQSKVSADRIASYLQQSETQKDAVEYCSKDHT------ELSVEIENGAFSWEPESSR 645

  Fly   428 PVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVR 492
            |.|::|.:.:.....|||.|.||||||||:.:||||:....|.::|.|..:|..|.||:.:.::|
plant   646 PTLDDIELKVKSGMKVAVCGAVGSGKSSLLSSILGEIQKLKGTVRVSGKQAYVPQSPWILSGTIR 710

  Fly   493 DNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADT 556
            ||||||...:..:|...::.|||.:||||. :||.|.:||||.::||||:.||.:|||||:.||.
plant   711 DNILFGSMYESEKYERTVKACALIKDFELFSNGDLTEIGERGINMSGGQKQRIQIARAVYQNADI 775

  Fly   557 YLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEM 621
            ||||||.||||.|.||.|||:|:.|.|:||.|:.||||::||..||||::|..|::...|.:||:
plant   776 YLLDDPFSAVDAHTGRELFEDCLMGILKDKTVLYVTHQVEFLPAADLILVMQNGRVMQAGKFEEL 840

  Fly   622 LKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNE 686
            ||....|..|:....:.: ||   .::.|..|||.|......::.::....|..||......:|:
plant   841 LKQNIGFEVLVGAHNEAL-DS---ILSIEKSSRNFKEGSKDDTASIAESLQTHCDSEHNISTENK 901

  Fly   687 RQPAQ----ESRSQGKIGLGIYGKYFSAGSGWLMV--ILVAFFCLGTQILASGGDYFLSYWVKNN 745
            ::.|:    |...:|.||..:|..|.:...|.|:|  |::|..|.  |:|....:|::: |....
plant   902 KKEAKLVQDEETEKGVIGKEVYLAYLTTVKGGLLVPFIILAQSCF--QMLQIASNYWMA-WTAPP 963

  Fly   746 DSSSSTDIYIFSGINAALVIFALL----------RTLLFFSMAMHSSTQLHNTMFQGVSRTALYF 800
            .:.|...:    |:...|:::|||          ||:|.....:.::....:.|...:.|..:.|
plant   964 TAESIPKL----GMGRILLVYALLAAGSSLCVLARTILVAIGGLSTAETFFSRMLCSIFRAPMSF 1024

  Fly   801 FHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHF 865
            |.:.|:||||||.:.|...:|..:...:..|....:.|.|.|.|:........:..|.:.:|..|
plant  1025 FDSTPTGRILNRASTDQSVLDLEMAVKLGWCAFSIIQIVGTIFVMSQVAWQVCVIFIPVAVACVF 1089

  Fly   866 LRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFL 930
            .:.:|..|:|:|.|:..:.|:|:..||:.:|.|.:||||.:.:|..........|.||..::...
plant  1090 YQRYYTPTARELSRMSGVERAPILHHFAESLAGATTIRAFDQRDRFISSNLVLIDSHSRPWFHVA 1154

  Fly   931 STNRAFGYYLDL-----FCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMT---GTVQWGMRQ 987
            |......:.|:|     |..:.|:.|||..    .|.||...||.:|..:|:.   .||.|.:
plant  1155 SAMEWLSFRLNLLSHFVFAFSLVLLVTLPE----GVINPSIAGLGVTYGLSLNVLQATVIWNI-- 1213

  Fly   988 SAELENSMTSVERVLEYRHLEAEGEFESP---DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRV 1049
             ...||.|.||||:|:|..:.:    |:|   |..:|..|||..|.|....|.:||.....|  |
plant  1214 -CNAENKMISVERILQYSKIPS----EAPLVIDGHRPLDNWPNVGSIVFRDLQVRYAEHFPA--V 1271

  Fly  1050 LKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIP 1113
            ||::.......:|||:|||||:|||:||.||||: ..::|::||||.||..||||||||::.|||
plant  1272 LKNITCEFPGGKKIGVVGRTGSGKSTLIQALFRIVEPSQGTIVIDNVDITKIGLHDLRSRLGIIP 1336

  Fly  1114 QEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVC 1178
            |:|.||.||:|.||||..||.|.::|||:::..|.|.:......|::.|.|.|.|:|||||||||
plant  1337 QDPALFDGTIRLNLDPLAQYTDHEIWEAIDKCQLGDVIRAKDERLDATVVENGENWSVGQRQLVC 1401

  Fly  1179 LARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGT 1243
            |.|.:|:::.|||:|||||:||..||.:||..|.::|:|.||:|||||::|:|:||.|:||..|.
plant  1402 LGRVLLKKSNILVLDEATASVDSATDGVIQKIINQEFKDRTVVTIAHRIHTVIESDLVLVLSDGR 1466

  Fly  1244 LVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLK 1279
            :.||.||.:|             ||...|.|..|:|
plant  1467 IAEFDSPAKL-------------LQREDSFFSKLIK 1489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	426/1312 (32%)
		ABC_membrane	92..362	CDD:294371	63/284 (22%)
		ABCC_MRP_domain1	412..611	CDD:213217	96/199 (48%)
		ABC_membrane	718..981	CDD:294371	71/280 (25%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	114/221 (52%)
ABCC9	NP_191575.2	PLN03232	68..1488	CDD:215640	430/1333 (32%)
		ABC_membrane	319..586	CDD:294371	63/281 (22%)
		ABCC_MRP_domain1	630..830	CDD:213217	96/199 (48%)
		ABC_membrane	973..1209	CDD:294371	62/239 (26%)
		ABCC_MRP_domain2	1253..1473	CDD:213211	114/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720