DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC6

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_187916.3	Gene:	ABCC6 / 820497	AraportID:	AT3G13090	Length:	1466	Species:	Arabidopsis thaliana

Alignment Length:	1321	Identity:	448/1321 - (33%)
Similarity:	693/1321 - (52%)	Gaps:	122/1321 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDS 72
            |.|...|||.|.:.|.:..|::..|.:|.::..|:....:....|:|    |..::|::.  .|.
plant   206 TAPFSKAGILSRMSFSWMSPLITLGNEKIIDIKDVPQLDRSDTTESL----FWIFRSKLE--WDD 264

  Fly    73 PKKEPSIIRVILKVF--GWQ-LFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIY 134
            .::..:..::|..:|  .|: :.||.::..|..:..     .:...|:..|.:..||:..:.. .
plant   265 GERRITTFKLIKALFLSVWRDIVLSALLAFVYTVSC-----YVAPYLMDNFVQYLNGNRQYKN-Q 323

  Fly   135 GLTLILSILFSVLM---------FHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQ 190
            |..|:.:...:.|:         |.....||     .||..:.:.||.|.|.|...:....|:|:
plant   324 GYVLVTTFFVAKLVECQTQRQWFFRGQKAGL-----GMRSVLVSMIYEKGLTLPCHSKQGHTSGE 383

  Fly   191 VVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLT 255
            ::||::.|..|........|..|:..|::.::.:.||:.:|:.|:......:|.:......::|.
plant   384 IINLMAVDADRISAFSWFMHDPWILVLQVSLALWILYKSLGLGSIAAFPATILVMLANYPFAKLE 448

  Fly   256 SRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSF 320
            .:.:.......|.|::..:|::..::::|:..||..|...|..||..|...::|..|....:.|
plant   449 EKFQSSLMKSKDNRMKKTSEVLLNMKILKLQGWEMKFLSKILELRHIEAGWLKKFVYNSSAINS- 512

  Fly   321 EITLSRIAIFVSLLGF---VLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRR 382
              .|.....|:|...|   :|:...|.:.:..:..|.:.||:..:.| .|..:|...:..|:|.|
plant   513 --VLWAAPSFISATAFGACLLLKIPLESGKILAALATFRILQGPIYK-LPETISMIVQTKVSLNR 574

  Fly   383 IKGFMMRSETEALYLKGGQTNKLFEG--EPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAV 445
            |..|:...:     |:.....:|..|  |..|::.:....|:.....|.|.::|..:|....||:
plant   575 IASFLCLDD-----LQQDVVGRLPSGSSEMAVEISNGTFSWDDSSPIPTLRDMNFKVSQGMNVAI 634

  Fly   446 IGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVI 510
            .|.||||||||:.:||||:|..||.|||.|..:|.:|.||:.:..|.:|||||.||::..|..|:
plant   635 CGTVGSGKSSLLSSILGEVPKISGNLKVCGRKAYIAQSPWIQSGKVEENILFGKPMEREWYDRVL 699

  Fly   511 RNCALERDFELL--HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRH 573
            ..|:|.:|.|:|  | |:|.:||||.:|||||:.||.:|||:|:.||.||.|||.||||.|.|.|
plant   700 EACSLNKDLEILPFH-DQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSH 763

  Fly   574 LFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLA--TEA 636
            ||:|.:.|.||.|.||.||||::||..||||::|..|||:..|.|.|:|.||.||.:|:.  |||
plant   764 LFKEVLLGLLRHKTVIYVTHQVEFLPEADLILVMKDGKITQAGKYHEILDSGTDFMELVGAHTEA 828

  Fly   637 QEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPA-----QESRSQ 696
            ....||      .|....::|||..:::      .|.......|:..||  :|:     :|.|.:
plant   829 LATIDS------CETGYASEKSTTDKEN------EVLHHKEKQENGSDN--KPSGQLVQEEEREK 879

  Fly   697 GKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTD--------- 752
            ||:|..:|.||.:...|..::.|:....:..|:|:.|.:|::: ||    :..|.|
plant   880 GKVGFTVYKKYMALAYGGAVIPLILVVQVLFQLLSIGSNYWMT-WV----TPVSKDVEPPVSGFT 939

  Fly   753 ---IYIFSGINAA--LVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNR 812
               :|:...:.::  ::|.|||..:..|.||....||:|..:|    |.::.||.|.|.||||||
plant   940 LILVYVLLAVASSFCILIRALLVAMTGFKMATELFTQMHLRIF----RASMSFFDATPMGRILNR 1000

  Fly   813 FAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPW-YLINTITMFLAFHFLRTFYLSTSRD 876
            .:.|....|..||..........:.|.|||||: :...| .||..|.:..|..:.|.:|:|.:|:
plant  1001 ASTDQSVADLRLPGQFAYVAIAAINILGIIGVI-VQVAWQVLIVFIPVVAACAWYRQYYISAARE 1064

  Fly   877 LKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQD------IHSSGYYTFLSTNRA 935
            |.||..|:|||:..|||.||:|::|||:.:.:.....:.....|      .||:|...:|.
plant  1065 LARLAGISRSPVVHHFSETLSGITTIRSFDQEPRFRGDIMRLSDCYSRLKFHSTGAMEWLC---- 1125

  Fly   936 FGYYLDLFCV-AYVISVTLMSYFNPPVDNPGQIGLVITQAMSMT---GTVQWGMRQSAELENSMT 996
              :.|:|... |:..|:.::......|.||...||.||.|:::.   .|:.|.:   .:|||.|.
plant  1126 --FRLELLSTFAFASSLVILVSAPEGVINPSLAGLAITYALNLNTLQATLIWTL---CDLENKMI 1185

  Fly   997 SVERVLEYRHLEAEGEFESP---DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIM 1058
            ||||:|:|.::.:    |.|   :..:|..:||..|.|:...|.:||.  |....||..|.....
plant  1186 SVERMLQYTNIPS----EPPLVIETTRPEKSWPSRGEITICNLQVRYG--PHLPMVLHGLTCTFP 1244

  Fly  1059 PREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGT 1122
            ...|.|||||||.|||:||..|||: ....|.:.||..:||.||||||||::|||||:|.:|.||
plant  1245 GGLKTGIVGRTGCGKSTLIQTLFRIVEPAAGEIRIDGINILSIGLHDLRSRLSIIPQDPTMFEGT 1309

  Fly  1123 LRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILREN 1187
            :|.||||.|:|.|:::||||:...|.|||.:....|:|.|:|.|.|:||||||||||.|.:|:.:
plant  1310 IRSNLDPLEEYTDDQIWEALDNCQLGDEVRKKELKLDSPVSENGQNWSVGQRQLVCLGRVLLKRS 1374

  Fly  1188 RILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFE 1252
            ::||:|||||::|..||.|||.|:|..|.||||:|||||::::||||.|::||.|.:.|..||..
plant  1375 KLLVLDEATASIDTATDNLIQETLRHHFADCTVITIAHRISSVIDSDMVLLLDQGLIKEHDSPAR 1439

  Fly  1253 LLTQSWSKVFYGMVLQTGRSS 1273
            || :..|.:|..:|.:...||
plant  1440 LL-EDRSSLFSKLVAEYTTSS 1459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	443/1303 (34%)
		ABC_membrane	92..362	CDD:294371	58/281 (21%)
		ABCC_MRP_domain1	412..611	CDD:213217	99/200 (50%)
		ABC_membrane	718..981	CDD:294371	84/287 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	115/221 (52%)
ABCC6	NP_187916.3	PLN03232	67..1452	CDD:215640	445/1312 (34%)
		ABC_membrane	286..555	CDD:294371	58/282 (21%)
		ABCC_MRP_domain1	601..801	CDD:213217	99/200 (50%)
		ABC_membrane	902..1173	CDD:294371	84/286 (29%)
		ABCC_MRP_domain2	1217..1437	CDD:213211	115/221 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720