DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC3

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_187915.1	Gene:	ABCC3 / 820496	AraportID:	AT3G13080	Length:	1514	Species:	Arabidopsis thaliana

Alignment Length:	1319	Identity:	440/1319 - (33%)
Similarity:	699/1319 - (52%)	Gaps:	102/1319 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAET---LGDKFFATWQSEVRS 68
            :..|...|||.|.|.|.:..|::..|.||||   ||.:..:.|..::   |..||        ||
plant   242 EATPYSRAGILSLLTFSWMSPLIDIGNKKTL---DLEDVPQLHDTDSVVGLAPKF--------RS 295

  Fly    69 CGDSPK-KEPS------IIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILG-ALIAEFTRNGN 125
            ..:||. .|.|      :|:.:.....|::.::.....:.      |:...:| |||..|.:..|
plant   296 MLESPDGGERSGVTTFKLIKALYFTAQWEILVTAFFAFIY------TVASYVGPALIDTFVQYLN 354

  Fly   126 GDGLW---AQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTT 187
            |...:   ..:..:|...:.:...|........|..:.::||.|:...||.|.|.||..:....|
plant   355 GRRQYNHEGYVLVITFFAAKIVECLSQRHWFFRLQKVGIRMRSALVAMIYEKGLTLSCQSKQGRT 419

  Fly   188 TGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLS 252
            :|:::|.::.|..|......:.|..|:..|::.::.:.||:.:|:||:..:|..::.:.|.....
plant   420 SGEIINFMTVDAERIGNFSWYMHDPWMVLLQVGLALWILYRNLGLASIAALVATIIVMLINFPFG 484

  Fly   253 RLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTL 317
            |:..|.:.:.....|.|::..:||:..::::|:..||..|...|..||:||...::|..| ...:
plant   485 RMQERFQEKLMEAKDSRMKSTSEILRNMRILKLQGWEMKFLSKIFDLRKSEEGWLKKYVY-NSAV 548

  Fly   318 LSFEITLSRIAIFVSLLG-FVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLR 381
            :||....:...:.||..| .:|:|..|.:.:..|..|.:.||:..:.. .|..:|...:..|:|.
plant   549 ISFVFWGAPTLVSVSTFGACILLGIPLESGKILSALATFRILQEPIYN-LPDTISMIVQTKVSLD 612

  Fly   382 RIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQA--RWNHDHVEPVLENINISLSPPQLVA 444
            |:..::....     |:.....:|.:|...|.::...:  .|:.....|.|::||..:.|...||
plant   613 RLASYLCLDN-----LQPDIVERLPKGSSDVAVEVINSTLSWDVSSSNPTLKDINFKVFPGMKVA 672

  Fly   445 VIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNV 509
            |.|.||||||||:.::|||:|..||.|||.|..:|.:|.||:.:..:.||||||.||::.||..|
plant   673 VCGTVGSGKSSLLSSLLGEVPKVSGSLKVCGTKAYVAQSPWIQSGKIEDNILFGKPMERERYDKV 737

  Fly   510 IRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRH 573
            :..|:|.:|.|:| .||:|.:||||.:|||||:.||.:|||:|:.||.||.|||.||||.|.|.|
plant   738 LEACSLSKDLEILSFGDQTVIGERGINLSGGQKQRIQIARALYQDADIYLFDDPFSAVDAHTGSH 802

  Fly   574 LFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLAT--EA 636
            ||:|.:.|.|..|.||.||||::||..||||::|..|:||..|.|.::|.||.||.:|:..  ||
plant   803 LFKEVLLGLLCSKSVIYVTHQVEFLPAADLILVMKDGRISQAGKYNDILNSGTDFMELIGAHQEA 867

  Fly   637 QEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTES---------ILDNERQPAQ- 691
            ..:.||      .:.:|.::||...:::..|.  ...:||...||         .::.:||..|
plant   868 LAVVDS------VDANSVSEKSALGQENVIVK--DAIAVDEKLESQDLKNDKLESVEPQRQIIQE 924

  Fly   692 ESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGT---QILASGGDYFLSYWVKNNDS------ 747
            |.|.:|.:.|.:|.||.:...|.   .||.|..||.   |:|..|.:|::::....::.
plant   925 EEREKGSVALDVYWKYITLAYGG---ALVPFILLGQVLFQLLQIGSNYWMAWATPVSEDVQAPVK 986

  Fly   748 -SSSTDIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILN 811
             |:...:|:.....::|.|  |||..|..:....::|:|.:.|...:.|:.:.||.:.|||||::
plant   987 LSTLMIVYVALAFGSSLCI--LLRATLLVTAGYKTATELFHKMHHCIFRSPMSFFDSTPSGRIMS 1049

  Fly   812 RFAMDLGQVDEILP----AVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLS 872
            |.:.|...||..||    :|.:..||:.    |||||:...:....:..|.:..|..:.:.:|::
plant  1050 RASTDQSAVDLELPYQFGSVAITVIQLI----GIIGVMSQVSWLVFLVFIPVVAASIWYQRYYIA 1110

  Fly   873 TSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFG 937
            .:|:|.||..:.::|:..|||.|::|.:|||:...:.....:.....|.:|...:..........
plant  1111 AARELSRLVGVCKAPLIQHFSETISGATTIRSFSQEFRFRSDNMRLSDGYSRPKFYTAGAMEWLC 1175

  Fly   938 YYLD-LFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERV 1001
            :.|| |..:.:|.|:..:......|.:|...||.:|..:|:.....|.:.....|||.:.||||:
plant  1176 FRLDMLSSLTFVFSLVFLVSIPTGVIDPSLAGLAVTYGLSLNTLQAWLIWTLCNLENKIISVERI 1240

  Fly  1002 LEYRHLEAEGEFESP---DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKI 1063
            |:|..:.:    |.|   :..:|..:||..|.:....|.:||  .|....||:.:........:.
plant  1241 LQYASVPS----EPPLVIESNRPEQSWPSRGEVEIRDLQVRY--APHMPLVLRGITCTFKGGLRT 1299

  Fly  1064 GIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNL 1127
            |||||||:|||:||..|||: ..:.|.:.||..:||.|||||||.::|||||:|.:|.||:|.||
plant  1300 GIVGRTGSGKSTLIQTLFRIVEPSAGEIRIDGVNILTIGLHDLRLRLSIIPQDPTMFEGTMRSNL 1364

  Fly  1128 DPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVM 1192
            ||.|:|.|:::||||::..|.|||.:....|:|.|:|.|.|:|:||||||||.|.:|:.::|||:
plant  1365 DPLEEYTDDQIWEALDKCQLGDEVRKKEQKLDSSVSENGDNWSMGQRQLVCLGRVLLKRSKILVL 1429

  Fly  1193 DEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELL--- 1254
            |||||:||..||.|||.|:|..|.||||:|||||::::||||.|::|..|.:.|:.:|..||
plant  1430 DEATASVDTATDNLIQKTLREHFSDCTVITIAHRISSVIDSDMVLLLSNGIIEEYDTPVRLLEDK 1494

  Fly  1255 TQSWSKVFYGMVLQTGRSS 1273
            :.|:||:   :...|.|||
plant  1495 SSSFSKL---VAEYTSRSS 1510

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	433/1301 (33%)
		ABC_membrane	92..362	CDD:294371	64/274 (23%)
		ABCC_MRP_domain1	412..611	CDD:213217	100/201 (50%)
		ABC_membrane	718..981	CDD:294371	71/277 (26%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	111/221 (50%)
ABCC3	NP_187915.1	MRP_assoc_pro	115..1499	CDD:188098	434/1303 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H74563
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.720