DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC4

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_182301.1	Gene:	ABCC4 / 819392	AraportID:	AT2G47800	Length:	1516	Species:	Arabidopsis thaliana

Alignment Length:	1305	Identity:	456/1305 - (34%)
Similarity:	710/1305 - (54%)	Gaps:	125/1305 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 SAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEP 77
            ||.:||...:.:..|:|.||.|..|....:.....|||||.|...|.::|        ..|.:..
plant   254 SASVFSKTFWLWMNPLLSKGYKSPLTLEQVPTLSPEHKAERLALLFESSW--------PKPSENS 310

  Fly    78 S--IIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLIL 140
            |  |...:|:.| |:..|...::.::.||.....|:::.:.: :|| :|.....| |.|.|.|||
plant   311 SHPIRTTLLRCF-WKEILFTAILAIVRLGVMYVGPVLIQSFV-DFT-SGKRSSPW-QGYYLVLIL 371

  Fly   141 SI--LFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFD 203
            .:  ...||..|........|.|.:|..:.||:|:|.|:|:.:|..:...||:||.::.|..:..
plant   372 LVAKFVEVLTTHQFNFDSQKLGMLIRSTLITALYKKGLKLTGSARQNHGVGQIVNYMAVDAQQLS 436

  Fly   204 RALIHFHFLWLGPLELLISSYFLYQQIG---VASLYGIVILLLFLPIQTFLSRLTSRLRHQTAL- 264
            ..::..|.:||.||::.::...||..:|   :.::.|:..:.:|:.:.|..:.     .:|.:|
plant   437 DMMLQLHAIWLMPLQVTVALVLLYGSLGASVITAVIGLTGVFVFILLGTQRNN-----GYQFSLM 496

  Fly   265 -RTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNY-IRGTLLSFEITLSRI 327
             ..|.|::..||:::.::|||...||..|.:.|.:.|..|...:.|..| |.|.:    |.|...
plant   497 GNRDSRMKATNEMLNYMRVIKFQAWENHFNKRILKFRDMEFGWLSKFLYSIAGNI----IVLWST 557

  Fly   328 AIFVSLLGF---VLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMR 389
            .:.:|.|.|   :.:|.:|.|...|:.|..:.||:..: :.||..|...::.|::|.|:..:||.
plant   558 PVLISALTFATALALGVKLDAGTVFTTTTIFKILQEPI-RTFPQSMISLSQAMISLGRLDSYMMS 621

  Fly   390 SE--TEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSG 452
            .|  .:|:....|     .:|...|:::.....|:.:..||.|.:||..:...:|.|::|.||||
plant   622 KELSEDAVERALG-----CDGNTAVEVRDGSFSWDDEDNEPALSDINFKVKKGELTAIVGTVGSG 681

  Fly   453 KSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALER 517
            ||||:.::|||:...||:::|.|...|.:|..|:.|.:|:|||||||||.:.:|..|:..|:||:
plant   682 KSSLLASVLGEMHRISGQVRVCGSTGYVAQTSWIENGTVQDNILFGLPMVREKYNKVLNVCSLEK 746

  Fly   518 DFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRG 581
            |.:::. ||:|.:||||.:|||||:.||.||||||::.|.|||||..||||.|.|..:|::|:||
plant   747 DLQMMEFGDKTEIGERGINLSGGQKQRIQLARAVYQECDVYLLDDVFSAVDAHTGSDIFKKCVRG 811

  Fly   582 FLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQ 646
            .|:.|.|:|||||:.||.:.|.|::|..|||...|.|:|::.||.|||:|:|..     :::.|.
plant   812 ALKGKTVLLVTHQVDFLHNVDCILVMRDGKIVESGKYDELVSSGLDFGELVAAH-----ETSMEL 871

  Fly   647 VNAEGDS-------RNDKSTYSRQSSRVSRVSVTSVDSSTESIL---------DNERQPAQESRS 695
            |.|..||       |...|.:: .|.|.|..|....|.:.|.|.         |..:...:|.|.
plant   872 VEAGADSAAVATSPRTPTSPHA-SSPRTSMESPHLSDLNDEHIKSFLGSHIVEDGSKLIKEEERE 935

  Fly   696 QGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVK-NNDSSSSTDIYIFSGI 759
            .|::.||:|.:|.:...||..::||.||.|..|......||:|:|... .|..|....::|...:
plant   936 TGQVSLGVYKQYCTEAYGWWGIVLVLFFSLTWQGSLMASDYWLAYETSAKNAISFDASVFILGYV 1000

  Fly   760 NAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALY----FFHANPSGRILNRFAMDLGQV 820
            ..|||...|:....::  ..|...:.....|:.:..:.|:    ||...||||||:|.:.|...|
plant  1001 IIALVSIVLVSIRSYY--VTHLGLKTAQIFFRQILNSILHAPMSFFDTTPSGRILSRASTDQTNV 1063

  Fly   821 DEILPAVMLDCIQIFLTISGIIGVLC--------------ITNPWYLINTITMFLAFHFLRTFYL 871
            |.::|.::...:.::.|:..|..|.|              ..|.||              |.:||
plant  1064 DILIPFMLGLVVSMYTTLLSIFIVTCQYAWPTAFFVIPLGWLNIWY--------------RNYYL 1114

  Fly   872 STSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKE-----YDNYQ-DIHSSGYYTFL 930
            ::||:|.|:::|.::|:..|||.::.|:.|||:...|:|..:|     .||.: |.|::|
plant  1115 ASSRELTRMDSITKAPIIHHFSESIAGVMTIRSFRKQELFRQENVKRVNDNLRMDFHNNG----- 1174

  Fly   931 STNRAFGYYLDL-----FCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAE 990
             :|...|:.|:|     .|::.:..|.|.|    .|..|..:||.::..:|:...:.:.:..|..
plant  1175 -SNEWLGFRLELVGSWVLCISALFMVLLPS----NVIRPENVGLSLSYGLSLNSVLFFAIYMSCF 1234

  Fly   991 LENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNF 1055
            :||.|.||||:.::..:.:|.|:|. .:..||.|||..|.:..|.|.:||.|:  ...|||.:..
plant  1235 VENKMVSVERIKQFTDIPSESEWER-KETLPPSNWPFHGNVHLEDLKVRYRPN--TPLVLKGITL 1296

  Fly  1056 IIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLF 1119
            .|...||:|:|||||:|||:||..|||| ..:.|.::||..||..:|||||||:..|||||||||
plant  1297 DIKGGEKVGVVGRTGSGKSTLIQVLFRLVEPSGGKIIIDGIDISTLGLHDLRSRFGIIPQEPVLF 1361

  Fly  1120 SGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAIL 1184
            .||:|.|:||.|||:||::|::||...|||.|:..|..|:|:|.:.|.|:|||||||:||.|.:|
plant  1362 EGTVRSNIDPTEQYSDEEIWKSLERCQLKDVVATKPEKLDSLVVDNGENWSVGQRQLLCLGRVML 1426

  Fly  1185 RENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGS 1249
            :.:|:|.:|||||:||.||||:||..||..|..||:::||||:.|::|.|||:|:|||...||.|
plant  1427 KRSRLLFLDEATASVDSQTDAVIQKIIREDFASCTIISIAHRIPTVMDGDRVLVIDAGKAKEFDS 1491

  Fly  1250 PFELL 1254
            |..||
plant  1492 PARLL 1496

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	456/1305 (35%)
		ABC_membrane	92..362	CDD:294371	74/280 (26%)
		ABCC_MRP_domain1	412..611	CDD:213217	94/199 (47%)
		ABC_membrane	718..981	CDD:294371	77/292 (26%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	118/221 (53%)
ABCC4	NP_182301.1	CFTR_protein	255..1502	CDD:273530	455/1304 (35%)
		ABC_membrane	331..595	CDD:294371	73/275 (27%)
		ABCC_MRP_domain1	641..841	CDD:213217	94/199 (47%)
		ABC_membrane	976..1229	CDD:294371	70/278 (25%)
		ABCC_MRP_domain2	1272..1492	CDD:213211	118/221 (53%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	99	1.000	Domainoid score	I2369
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720