DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC2

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001189675.1	Gene:	ABCC2 / 818031	AraportID:	AT2G34660	Length:	1623	Species:	Arabidopsis thaliana

Alignment Length:	1331	Identity:	466/1331 - (35%)
Similarity:	734/1331 - (55%)	Gaps:	116/1331 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGD 71
            |..|.:.|.||..:.|.:..|::..|.|:.|...|::......:.|||...|..:|..|::
plant   224 QICPEKHANIFDKIFFSWMNPLMTLGSKRPLTEKDVWYLDTWDQTETLFTSFQHSWDKELQ---- 284

  Fly    72 SPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATL---PLILGALIAEFTRNGNGDGLW-AQ 132
              |.:|.::|.:....|.:.:..|.    .::|...:.   ||:|..|:.....:...   | ..
plant   285 --KPQPWLLRALNNSLGGRFWWGGF----WKIGNDCSQFVGPLLLNQLLKSMQEDAPA---WMGY 340

  Fly   133 IYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISN 197
            ||..::.:.::|.||........:|.:..::|.|:..|::||:|||:........||::.||::.
plant   341 IYAFSIFVGVVFGVLCEAQYFQNVMRVGYRLRSALIAAVFRKSLRLTNEGRRKFQTGKITNLMTT 405

  Fly   198 DLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQT 262
            |.....:.....|.:|..|..::|:...||||:|||||.|.::|:|..|:||.:.....:|..:.
plant   406 DAESLQQICQSLHTMWSAPFRIIIALILLYQQLGVASLIGALLLVLMFPLQTVIISKMQKLTKEG 470

  Fly   263 ALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRI 327
            ..|||:|:.:|||:::.:..:|.|.||..|...::.:|..|:|..|| :.:.|.|..|  .|:.|
plant   471 LQRTDKRIGLMNEVLAAMDTVKCYAWENSFQSKVQTVRDDELSWFRK-SQLLGALNMF--ILNSI 532

  Fly   328 AIFVSLLG---FVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMR 389
            .:.|:::.   |.|:||:||..|||:..:.:.:||..:. ..|:.::|.....|:|:|::..:..
plant   533 PVLVTIVSFGVFTLLGGDLTPARAFTSLSLFAVLRFPLF-MLPNIITQVVNANVSLKRLEEVLAT 596

  Fly   390 SETEALYLKGGQTNKLFE-GEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGK 453
            .|...|      .|...| |||.:.:::....|:.....|.|.|||:.:....||||:|..|.||
plant   597 EERILL------PNPPIEPGEPAISIRNGYFSWDSKGDRPTLSNINLDVPLGSLVAVVGSTGEGK 655

  Fly   454 SSLIQAILGELPGESGKL-KVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALER 517
            :|||.|||||||..|..: .::|.::|..|..|:|||:||||||||.|.|:.:|...|...:|:.
plant   656 TSLISAILGELPATSDAIVTLRGSVAYVPQVSWIFNATVRDNILFGSPFDREKYERAIDVTSLKH 720

  Fly   518 DFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRG 581
            |.||| .||.|.:||||.::||||:.|:|:|||||..:|.|:.||||||:|.|||:.:||:|::.
plant   721 DLELLPGGDLTEIGERGVNISGGQKQRVSMARAVYSNSDVYIFDDPLSALDAHVGQQVFEKCIKR 785

  Fly   582 FLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATE------AQEMG 640
            .|..|..:|||:||.||...|.||::.:|.:...|||||:..:|..|.:|:...      ::|.|
plant   786 ELGQKTRVLVTNQLHFLSQVDRIVLVHEGTVKEEGTYEELSSNGPLFQRLMENAGKVEEYSEENG 850

  Fly   641 DSNQEQV--------NAEG---DSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQESR 694
            ::..:|.        |..|   |..:||.  |::.::....||..               .||.|
plant   851 EAEADQTAEQPVANGNTNGLQMDGSDDKK--SKEGNKKGGKSVLI---------------KQEER 898

  Fly   695 SQGKIGLGIYGKYFSA-GSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTDIY---I 755
            ..|.:...:..:|..| |..|::::|:..:.| |::.......:||.|.......|...::   |
plant   899 ETGVVSWRVLKRYQDALGGAWVVMMLLLCYVL-TEVFRVTSSTWLSEWTDAGTPKSHGPLFYNLI 962

  Fly   756 FSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQV 820
            ::.::...|:..|..:......:::::.:||:.|...:.|..:.|||.||.|||:||||.|||.:
plant   963 YALLSFGQVLVTLTNSYWLIMSSLYAAKKLHDNMLHSILRAPMSFFHTNPLGRIINRFAKDLGDI 1027

  Fly   821 DEILPAVMLDCI-----QIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRL 880
            |..: ||.::..     |:..|:. :||::...:.|.::..:.:|...:.   :|.:|:|::||:
plant  1028 DRTV-AVFVNMFMGQVSQLLSTVV-LIGIVSTLSLWAIMPLLVLFYGAYL---YYQNTAREVKRM 1087

  Fly   881 EAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGY-----YTF--LSTNRAFGY 938
            ::|:|||:|:.|...|||||||||.:|       ||...||:....     :|.  :..||..|.
plant  1088 DSISRSPVYAQFGEALNGLSTIRAYKA-------YDRMADINGRSMDNNIRFTLVNMGANRWLGI 1145

  Fly   939 YLDL---FCVAYVISVTLMSYFNPPVDN----PGQIGLVITQAMSMTGTVQWGMRQSAELENSMT 996
            .|:.   ..:....|..:|.  |...:|    ...:||:::.|:::|..:...:|.::..|||:.
plant  1146 RLETLGGLMIWLTASFAVMQ--NGRAENQQAFASTMGLLLSYALNITSLLTGVLRLASLAENSLN 1208

  Fly   997 SVERVLEYRHLEAEGEFESP---DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIM 1058
            :||||..|..:..    |:|   ::.:||..||..|.|..|.:.|||.  |:...||..::|.|.
plant  1209 AVERVGNYIEIPP----EAPPVIENNRPPPGWPSSGSIKFEDVVLRYR--PQLPPVLHGVSFFIH 1267

  Fly  1059 PREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGT 1122
            |.:|:|||||||||||||:|||||: ...:|.::||:.|:...||.|||..:.||||.|||||||
plant  1268 PTDKVGIVGRTGAGKSSLLNALFRIVEVEKGRILIDDCDVGKFGLMDLRKVLGIIPQSPVLFSGT 1332

  Fly  1123 LRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILREN 1187
            :|.|||||.::.|..|||:||..||||.:...|.||::.|:|.|.|:|||||||:.|:||:||.:
plant  1333 VRFNLDPFGEHNDADLWESLERAHLKDTIRRNPLGLDAEVSEAGENFSVGQRQLLSLSRALLRRS 1397

  Fly  1188 RILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFE 1252
            :|||:|||||.||.:||||||.|||.:|:.||:|.||||||||||.|:::|||:|.:.||.||..
plant  1398 KILVLDEATAAVDVRTDALIQKTIREEFKSCTMLIIAHRLNTIIDCDKILVLDSGRVQEFSSPEN 1462

  Fly  1253 LLTQSWSKVFYGMVLQTGRSSFEHLLKLALE 1283
            ||:...|. |..||..||.::.|:|..|.|:
plant  1463 LLSNEGSS-FSKMVQSTGAANAEYLRSLVLD 1492

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	456/1303 (35%)
		ABC_membrane	92..362	CDD:294371	80/276 (29%)
		ABCC_MRP_domain1	412..611	CDD:213217	94/200 (47%)
		ABC_membrane	718..981	CDD:294371	76/284 (27%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	126/221 (57%)
ABCC2	NP_001189675.1	PLN03130	1..1623	CDD:215595	466/1331 (35%)
		ABC_membrane	309..570	CDD:279056	79/266 (30%)
		ABCC_MRP_domain1	614..815	CDD:213217	94/200 (47%)
		ABC_membrane	925..1179	CDD:294371	71/268 (26%)
		ABCC_MRP_domain2	1240..1460	CDD:213211	126/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.720