DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc6

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_112275.1	Gene:	Abcc6 / 81642	RGDID:	620268	Length:	1502	Species:	Rattus norvegicus

Alignment Length:	1334	Identity:	421/1334 - (31%)
Similarity:	680/1334 - (50%)	Gaps:	102/1334 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQ---S 64
            :|.|...|...|...|..||.:|..:|:||.:|.|.|.||::..:|:.:|.|..:....|:   |
  Rat   203 SKPLNPCPEAEASFPSKAMFWWASGLLWKGYRKLLGPKDLWSLERENSSEELVSQLEREWRRNFS 267

  Fly    65 EV-----RSCGDSPKKEP----------SIIRVILKVFGWQLFLSGIVVGVLEL----GTRATLP 110
            |:     .|...:|:.|.          .::|.|     |::|.|..::|.|.|    ..|..:|
  Rat   268 ELPGHKGHSGMGTPETEAFLQPERSQRGPLLRAI-----WRVFRSTFLLGTLSLVISDAFRFAVP 327

  Fly   111 LILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKA 175
            .:| :|..||..:.........:..:.:.||.....|.....|..:..|.|::|.|::..:|||.
  Rat   328 KLL-SLFLEFMGDLESSAWTGWLLAVLMFLSACLQTLFEQQYMYRVKVLQMRLRTAITGLVYRKV 391

  Fly   176 LRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVI 240
            |.||..:...:..|.||||:|.|:.|...:::|.:.|||..|.:::...:|:|.:|.::|..:.:
  Rat   392 LVLSSGSRKSSAAGDVVNLVSVDVQRLVESILHLNGLWLLFLWIIVCFVYLWQLLGPSALTAVAV 456

  Fly   241 LLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMS 305
            .|..||:..|:::..|..:.:...:...|.|:.:.::..::.||.:.||..|...:..:|..|:.
  Rat   457 FLSLLPLNFFITKKRSFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWECAFLERLLHIRGQELG 521

  Fly   306 SIRKVNYIRG-TLLSFEITLSRIAIFV-SLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPS 368
            :::...::.. :|:||:::...:|:.| ::...|.....:.||:||......:||.:... |.|.
  Rat   522 ALKTSAFLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQA-FLPF 585

  Fly   369 GMSQFAEMMVTLRRIKGFMMRSETE--ALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLE 431
            .:....:..|:..|:..|:...|.:  .:.|...:.:    .:..:.:.:....|:.:. .|.|.
  Rat   586 SVHCLVQARVSFDRLAAFLCLEEVDPNGMVLSPSRCS----SKDRISIHNGTFAWSQES-PPCLH 645

  Fly   432 NINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNIL 496
            .||:::....|:||:||||:|||||:.|:||||....|.:.::|.::|..||.|:.|.||.:|:.
  Rat   646 GINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVENVC 710

  Fly   497 FGLPMDKHRYRNVIRNCALERDF-ELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLD 560
            |...:|....:.|:..|||..|. ....|..|.|||:|.:|||||:.|:||||||||:|..||:|
  Rat   711 FRQELDLPWLQEVLEACALGSDVASFPAGVHTPVGEQGMNLSGGQKQRLSLARAVYRRAAVYLMD 775

  Fly   561 DPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLK 623
            |||:|:|.||.:.:|::.:  .|.|:....|||||.|..|..||.|:::..|.|:.:|:|:::|.
  Rat   776 DPLAALDAHVSQEVFKQVIGPSGLLQGTTRILVTHTLHVLPQADQILVLANGTIAEMGSYQDLLH 840

  Fly   624 SGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDK-------STYSRQSSRVSRVSVTSVDSST-- 679
            .......||....|..|:...|   |...:.:|.       .|.:|:..|........|..||
  Rat   841 RNGALVGLLDGARQPAGEGEGE---AHAAATSDDLGGFSGGGTPTRRPERPRPSDAAPVKGSTSE 902

  Fly   680 ---ESILDNER----QPAQESRSQGKIGLGIYGKYFSA-GSGWLMVILVAFFCLGTQILASGGDY 736
               |..||:..    ...::|...|::....|..|..| |:......|..|.|  .|:.:....|
  Rat   903 AQMEPSLDDVEVTGLTAGEDSVQYGRVKSATYLSYLRAVGTPLCTYTLFLFLC--QQVASFCQGY 965

  Fly   737 FLSYWVKNNDSSSSTDIYIFSG--INAAL--VIFALLRTL----LFFSMA------MHSSTQLHN 787
            :||.|         .|..:..|  :::||  .||.||..|    ||.|||      ..:|..|..
  Rat   966 WLSLW---------ADDPVVDGKQMHSALRGSIFGLLGCLQAIGLFASMAAVFLGGARASCLLFR 1021

  Fly   788 TMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTIS-GIIGV---LCIT 848
            ::...|:|:.:.||...|.|.:||||:.:...||..:|    |.::..||.: |::.|   :.:.
  Rat  1022 SLLWDVARSPIGFFERTPVGNLLNRFSKETDIVDVDIP----DKMRTLLTYAFGLLEVGLAVSMA 1082

  Fly   849 NPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTK 913
            .|..::..:.:.|.:...::.|::|...|:|||:.:.|.:.||.:.|..|...:||.:||...|.
  Rat  1083 TPLAIVAILPLMLLYAGFQSLYVATCCQLRRLESASYSSVCSHLAETFQGSQVVRAFQAQGPFTA 1147

  Fly   914 EYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMT 978
            ::|...|.:....:..|..:|.....|:|.....|......:..:....:.|..|..::.|:.:|
  Rat  1148 QHDALMDENQRISFPRLVADRWLAANLELLGNGLVFVAATCAVLSKAHLSAGLAGFSVSAALQVT 1212

  Fly   979 GTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPD 1043
            .|:||.:|...:|||||.:||||.:|.|...|..:..|.....|: ||..|.|......||:.|:
  Rat  1213 QTLQWVVRSWTDLENSMVAVERVQDYVHTPKEAPWRLPSSAAQPL-WPCGGQIEFRDFGLRHRPE 1276

  Fly  1044 -PKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLR 1106
             |.|   ::.::..|...||:|||||||||||||...|.|| ...||.:.||...|..:|||.||
  Rat  1277 LPMA---VQGVSLKIHAGEKVGIVGRTGAGKSSLTWGLLRLQEATEGGIWIDGVPITDMGLHTLR 1338

  Fly  1107 SKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSV 1171
            |:|:||||:||||.|:||.|||..::..||.:|.|||.|.||..|:.||..|:...:..|.:.||
  Rat  1339 SRITIIPQDPVLFPGSLRMNLDLLQENTDEGIWAALETVQLKAFVTSLPGQLQYECSGQGDDLSV 1403

  Fly  1172 GQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRV 1236
            ||:||:|||||:||:.:||::|||||:|||.|:..:|:.:.|.|..||||.|||||.::::..||
  Rat  1404 GQKQLLCLARALLRKTQILILDEATASVDPGTEIQMQAALERWFAQCTVLLIAHRLRSVMNCARV 1468

  Fly  1237 MVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            :|:|.|.:.|.|||.:||.|  ..:||.:..::|
  Rat  1469 LVMDEGQVAESGSPAQLLAQ--KGLFYRLAQESG 1500

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	416/1316 (32%)
		ABC_membrane	92..362	CDD:294371	68/275 (25%)
		ABCC_MRP_domain1	412..611	CDD:213217	83/201 (41%)
		ABC_membrane	718..981	CDD:294371	71/280 (25%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	109/222 (49%)
Abcc6	NP_112275.1	MRP_assoc_pro	36..1501	CDD:188098	421/1334 (32%)
		ABC_membrane	313..577	CDD:294371	64/264 (24%)
		ABCC_MRP_domain1	627..828	CDD:213217	83/201 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..909		12/57 (21%)
		ABC_membrane	950..1215	CDD:294371	71/279 (25%)
		ABCC_MRP_domain2	1262..1482	CDD:213211	109/222 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345096
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.650