DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc3

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001350116.1	Gene:	Abcc3 / 76408	MGIID:	1923658	Length:	1523	Species:	Mus musculus

Alignment Length:	1360	Identity:	470/1360 - (34%)
Similarity:	742/1360 - (54%)	Gaps:	131/1360 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKLQTN--PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEV 66
            :.|.||  |..|||.||.|.|.:...:...|.::.||..||::..:|..:..:..:....||.:.
Mouse   200 ENLDTNPCPEASAGFFSRLSFWWFTRLAILGYRRPLEDRDLWSLSEEDCSHKVVQRLLEAWQKQQ 264

  Fly    67 RSCGDS--------------------PK-KEPSIIRVILKVFGWQLFLSGI------VVGVLELG 104
            .....|                    || |:||.:|.:::.|...|.:|..      ::|.:.
Mouse   265 NQASRSQTATAEPKIPGEDAVLLKPRPKSKQPSFLRALVRTFTSSLLMSACFNLIQNLLGFVN-- 327

  Fly   105 TRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVST 169
                 |.:|..|| .|..:......|..:....:.||.....|:.|.....:..:|:::|.|:..
Mouse   328 -----PQLLSILI-RFISDPTAPTWWGFLLAGLMFLSSTMQTLILHQYYHCIFVMALRLRTAIIG 386

  Fly   170 AIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVAS 234
            .||||||.::.:...::|.|::|||:|.|..||.......:.||..||:::::.|||:|.:|.::
Mouse   387 VIYRKALVITNSVKRESTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSA 451

  Fly   235 LYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERL 299
            |.|:.:::|.:|:...:|......:.:.....|.|:::|:||::||:|:|:|.||..|...::.:
Mouse   452 LAGVAVIVLLIPLNGAVSMKMKTYQVKQMKFKDSRIKLMSEILNGIKVLKLYAWEPSFLEQVKGI 516

  Fly   300 RRSEMSSIRKVNYIR--GTLL----SFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNIL 358
            |:||:..:||..|::  .|.:    .|.:||..:.::|    :|.....|.||:||...:.:|||
Mouse   517 RQSELQLLRKGAYLQAISTFIWICTPFLVTLITLGVYV----YVDESNVLDAEKAFVSLSLFNIL 577

  Fly   359 RRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNH 423
            :..: ...|..:|...:..|:|:||:.|:.::|.:...::    .|.......:.:.:....|..
Mouse   578 KIPL-NMLPQLISGLTQASVSLKRIQDFLNQNELDPQCVE----RKTISPGYAITIHNGTFTWAQ 637

  Fly   424 DHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFN 488
            | :.|.|.::||.:....||||:||||.|||||:.|:|||:....|.:.|:|.::|..|:.|:.|
Mouse   638 D-LPPTLHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGVVSVKGSVAYVPQQAWIQN 701

  Fly   489 ASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYR 552
            .::::|:|||.||:..||:..:..|||..|.::| .||:|.:||:|.:||||||.|:|||||||.
Mouse   702 CTLQENVLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYS 766

  Fly   553 QADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAV 615
            .|:.:||||||||||:||.:|:|::.:  .|.|..|..:||||.:.||...|.|:::..|::|.:
Mouse   767 DANIFLLDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLAGGQVSEM 831

  Fly   616 GTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDK--------STYSRQSS------R 666
            |.|..:|:....|...|...|.   |.:||...|...:.|::        ||::..:.      .
Mouse   832 GHYSALLQHDGSFANFLRNYAP---DEDQEDHEAALQNANEEVLLLEDTLSTHTDLTDNEPAIYE 893

  Fly   667 VSRVSVTSVDS-STESILDNERQPAQESRS-----------------------QGKIGLGIYGKY 707
            |.:..:..:.| |:|..:.|...|.:.:.|                       .|.:.|.:|..|
Mouse   894 VRKQFMREMSSLSSEGEVQNRTMPKKHTNSLEKEALVTKTKETGALIKEEIAETGNVKLSVYWDY 958

  Fly   708 FSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDS-----SSSTDIYIFSGINAAL-VIF 766
             :...|....:.:.....|....|.|.:.:||.|  :||:     .:.|.:.:  |:.||| ::.
Mouse   959 -AKSMGLCTTLSICLLYGGQSAAAIGANVWLSAW--SNDAEEHGQQNKTSVRL--GVYAALGILQ 1018

  Fly   767 ALLRTLLFFSM---AMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVM 828
            .||..|..|:|   |:.::..||..:.....|:...||...|||||||||:.|:..:||:|...:
Mouse  1019 GLLVMLSAFTMVVGAIQAARLLHEALLHNKIRSPQSFFDTTPSGRILNRFSKDIYVIDEVLAPTI 1083

  Fly   829 LDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFS 893
            |..:..|.|....|.|:..:.|.:::..:.:.:.:.|::.||::|||.|||||:|:|||::||||
Mouse  1084 LMLLNSFFTSISTIMVIVASTPLFMVVVLPLAVLYGFVQRFYVATSRQLKRLESISRSPIFSHFS 1148

  Fly   894 ATLNGLSTIRAM-EAQD---LLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLM 954
            .|:.|.|.|||. ..||   |...:.||.|    ...|.::::||..|.:::......|:...|.
Mouse  1149 ETVTGTSVIRAYGRIQDFKVLSDTKVDNNQ----KSSYPYIASNRWLGVHVEFVGNCVVLFAALF 1209

  Fly   955 SYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESP--- 1016
            :.......|||.:||.::.|:.:|..:.|.:|..::||:::.:||||.||    ::.:.|:|
Mouse  1210 AVIGRNSLNPGLVGLSVSYALQVTMALNWMIRMISDLESNIIAVERVKEY----SKTKTEAPWVV 1270

  Fly  1017 DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALF 1081
            :..:.|..||..|::.....|:||.|.  .:.|||::...:...||:||||||||||||:...||
Mouse  1271 ESNRAPEGWPTRGMVEFRNYSVRYRPG--LELVLKNVTVHVQGGEKVGIVGRTGAGKSSMTLCLF 1333

  Fly  1082 R-LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEV 1145
            | |...||.:|||..::..||||||||:::||||:|:|||||||.|||||.:|::|.:|.|||..
Mouse  1334 RILEAAEGEIVIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSEEDIWRALELS 1398

  Fly  1146 HLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQST 1210
            ||...||..|.||:...||||.|.|||||||||||||:||::|:||:|||||.:|.:||.|||.|
Mouse  1399 HLNTFVSSQPAGLDFQCAEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGT 1463

  Fly  1211 IRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            ||.:|.||||||||||||||:|.:||:|||.|.:.||.||..|:..  ..:||||....|
Mouse  1464 IRTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAA--GGIFYGMAKDAG 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	465/1343 (35%)
		ABC_membrane	92..362	CDD:294371	77/281 (27%)
		ABCC_MRP_domain1	412..611	CDD:213217	89/201 (44%)
		ABC_membrane	718..981	CDD:294371	87/275 (32%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	130/221 (59%)
Abcc3	NP_001350116.1	MRP_assoc_pro	7..1522	CDD:188098	470/1360 (35%)
Abcc3	NP_001350116.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	903..923		5/19 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841640
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660