DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcb8

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_083296.2	Gene:	Abcb8 / 74610	MGIID:	1351667	Length:	717	Species:	Mus musculus

Alignment Length:	641	Identity:	160/641 - (24%)
Similarity:	279/641 - (43%)	Gaps:	106/641 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 WQSEVRSC-------GDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATL---------- 109
            || ..|.|       .:||..:|:  |.....|.|:||...:...:|.||....|
Mouse    85 WQ-HPRLCLIALCEAKESPPAQPT--RAPELRFNWKLFWHFLHPHLLALGAAIVLALGAALVNVQ 146

  Fly   110 -PLILGAL---IAEFTRNGNGDGLWAQIYGLTLILSILFSV---LMFHPLMMGLMHLAMKMRVAV 167
             ||:||.|   :|::||:..|..: ::...|::.|.:|:.|   |.|..|:: |.|:..:|.:.:
Mouse   147 IPLLLGQLVEIVAKYTRDHMGSFV-SESRKLSVQLLLLYGVQGLLTFGYLVL-LSHIGERMAMDM 209

  Fly   168 STAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDR------------------ALIHFHFLWL 214
            ..|::...||..........|||:|:.::.|:..|..                  :|:....  |
Mouse   210 RKALFSSLLRQDIAFFDAKKTGQLVSRLTTDVQEFKSSFKLVISQGLRSCTQVIGSLVSLSM--L 272

  Fly   215 GPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISG 279
            .|...|:.:......:||.:|.|           :.|.:|:.:.:.|.|..|.    :.:|.:..
Mouse   273 SPRLTLMLAVVTPALMGVGTLMG-----------SGLRKLSRQCQEQIARATG----VADEALGN 322

  Fly   280 IQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFVSLLGFVLMGGELT 344
            ::.::.:..||   |..||.:....|...|...:...:..|: .||.||....:||.:.:||.|.
Mouse   323 VRTVRAFAMEK---REEERYQAELESCCCKAEELGRGIALFQ-GLSNIAFNCMVLGTLFIGGSLV 383

  Fly   345 AERAF---SVTAFYNILRRTVCKFFPSGMSQFAEMMVTL---RRIKGFMMRSETEALYLKGGQ-- 401
            |.:..   .:.:|. :..:||.:...|....|.:::..|   .|:..:|..|  ..:.|.||.
Mouse   384 AGQQLKGGDLMSFL-VASQTVQRSMASLSVLFGQVVRGLSAGARVFEYMALS--PVIPLTGGYCI 445

  Fly   402 TNKLFEGEPLVKLQ----SFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILG 462
            .||...|.  :..|    |:..|...:    ||::..:.|...::||::|..|.||:::...:..
Mouse   446 PNKDIRGS--ITFQNVTFSYPCRPGFN----VLKDFTLKLPSGKIVALVGQSGGGKTTVASLLER 504

  Fly   463 ELPGESGKLKVQGD--------------ISYASQEPWLFNASVRDNILFGL--PMDKHRYRNVIR 511
            ....|:|.:.:.|.              |.:.||||.||..::.:||.||.  ..|:..|.....
Mouse   505 FYDPEAGSVTLDGHDLRTLNPSWLRGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAARE 569

  Fly   512 NCALERDFELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFE 576
            ..|.|.......|..|.|||||.:|||||:.|:::|||:.:|....:||:..||:|....| :.:
Mouse   570 ANAHEFISSFPDGYSTVVGERGTTLSGGQKQRLAIARALIKQPTVLILDEATSALDAESER-VVQ 633

  Fly   577 ECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLL 632
            |.:......:.|:::.|:|..:..|..|::|..|::...||:||:||.|..:.:|:
Mouse   634 EALDRASAGRTVLVIAHRLSTVRAAHSIIVMANGQVCEAGTHEELLKKGGLYSELI 689

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	160/641 (25%)
		ABC_membrane	92..362	CDD:294371	66/307 (21%)
		ABCC_MRP_domain1	412..611	CDD:213217	60/218 (28%)
		ABC_membrane	718..981	CDD:294371
		ABCC_MRP_domain2	1029..1250	CDD:213211
Abcb8	NP_083296.2	MdlB	116..695	CDD:224055	151/607 (25%)
Abcb8	NP_083296.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	695..717
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000