Protein Alignment CG9270 and ABCC8

DIOPT Version :10

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: NP_001338224.1
• Gene: ABCC8 / 6833
• HGNCID: 59
• Length: 1603
• Species: Homo sapiens
• Alignment Length: 1479
• Identity: 421/1479 - (28%)
• Similarity: 703/1479 - (47%)
• Gaps: 272/1479 - (18%)

  Fly    17 FSTLMFCFA--LPIL-------------------FKGRKKTLEPTDLYNALKEHKAETLGDKFFA 60
            ||.|.||..  |.||                   ||..::...|.||         :.||.:|..
Human   164 FSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDL---------QDLGVRFLQ 219

  Fly    61 T-----------WQS-----------EVRSCGDSP--------------------KKE------- 76
            .           |.:           ::|:.|..|                    :|:
Human   220 PFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGA 284

  Fly    77 PSIIRVILKVFGWQLFLSG---IVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTL 138
            .:|.:.:...||.:|.||.   |:..:|....    ||.:..::....:..:......|..|:..
Human   285 RAIWQALSHAFGRRLVLSSTFRILADLLGFAG----PLCIFGIVDHLGKENDVFQPKTQFLGVYF 345

  Fly   139 ILS-------ILFSVLMFHPLMMGLMHL----------AMKMRVAVSTAIYRKALRLSRT--ALG 184
            :.|       .:.:||:|..|::....|          .:.:|.|:.|.||.|.:.||.:  ::|
Human   346 VSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMG 410

  Fly   185 DTTTGQVVNLISNDLGRFDRALIHFHF----LWLGPLELLISSYFLYQQIGVASLYGIVILLLFL 245
            :.|.||:.||::.|..:    |:.|.|    ||..|:::::....||..:||::|.|..:::|..
Human   411 EMTAGQICNLVAIDTNQ----LMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLA 471

  Fly   246 PIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKV 310
            |:|.|::...|:.:..|...:::|::..||::.||:::|:|.||..|...:|..||.||:|:|..
Human   472 PVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAF 536

  Fly   311 NYIRGTLLSFEITLSRIAIFVSLLGFV--LMGGELTAERAFSVTAFYNILRRTVCKFF--PSGMS 371
            .......:.....:...|:.::.:|.|  ....:.:...||:..:.::||   |...|  .|.:.
Human   537 AIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHIL---VTPLFLLSSVVR 598

  Fly   372 QFAEMMVTLRRIKGFM----MRSETEALY--LKGGQTNK---LFEG------------------E 409
            ...:.:|:::::..|:    :|.|..|.:  ...|..:|   :.||                  :
Human   599 STVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQ 663

  Fly   410 PL-----------------------------------VKLQSFQARWNHDHVEPVLENINISLSP 439
            ||                                   |::......|..|.: |.|.||.|.:..
Human   664 PLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGI-PTLSNITIRIPR 727

  Fly   440 PQLVAVIGPVGSGKSSLIQAILGELPGESG--------------------------KLKVQGDIS 478
            .||..::|.||.|||||:.|.|||:...||                          .::.:|.::
Human   728 GQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSLPDSEIGEDPSPERETATDLDIRKRGPVA 792

  Fly   479 YASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRA 542
            ||||:|||.||:|.:||:|..|.:|.||:.||..|:|:.|.::| |||:|.:||||.:||||||.
Human   793 YASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQ 857

  Fly   543 RISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRD--KLVILVTHQLQFLEHADLIV 605
            |||:|||:|:.|:...||||.||:|.|:..||.:..:...|||  :.|:||||:||:|.|||.|:
Human   858 RISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWII 922

  Fly   606 IMDKGKISAVGTYEEMLKSG----QDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSR 666
            .|..|.|...||.::..:|.    :.:..|:..:.||:                :|.|.:.:.:.
Human   923 AMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQEL----------------EKETVTERKAT 971

  Fly   667 VSRVSVTSVDSSTESILDNERQPAQES-------------RSQGKIGLGIYGKYFSAGSGWLMVI 718
            .....::...||.:.:|.:|.:..:|:             ..:.:|......||.|: :|.|::.
Human   972 EPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSS-AGILLLS 1035

  Fly   719 LVAFFCLGTQILASGGDYFLSYWVK--------------NNDSSSSTDIY--IFSGINAALVIFA 767
            |:.|..|...::....||:|:.|..              :.:.:....:|  :|:.:.:..::..
Human  1036 LLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVLC 1100

  Fly   768 LLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCI 832
            |:.::......:..:.:||.::...:....:.||...|.|.|||||:.|...:|:.:|:. |:|:
Human  1101 LVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECL 1164

  Fly   833 --QIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSAT 895
              ...|.:|. :.|:....|.:|:..:.:.:..:|::.::...||||::|:...:.|:.|||:.|
Human  1165 SRSTLLCVSA-LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAET 1228

  Fly   896 LNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLF--CVAYVISVTLMSYFN 958
            :.||:||||...:....::...|.|.::.......:.||.....::..  ||..:.:||.:|...
Human  1229 VEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNSL 1293

  Fly   959 PPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPM 1023
            ....:.|.:||.:|.|:.::..:.|.:|..|::|..:.:|:|:......|||...........|.
Human  1294 HRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIPK 1358

  Fly  1024 NWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNE 1087
            |||.:|.|..:.||:||  |.....|||.:|.:|.|.:||||.||||:||||...|.||: ...|
Human  1359 NWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTFE 1421

  Fly  1088 GSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVS 1152
            |.::||..||..:.||.|||::|||.|:|||||||:|.||||..:.:|..||||||...||..|.
Human  1422 GHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVVK 1486

  Fly  1153 ELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRD 1217
            .||.||::::.|||.|:|.|||||.|||||.:|:..|.:||||||::|..|:.::|..:...|.|
Human  1487 ALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFAD 1551

  Fly  1218 CTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMV 1266
            .||:|||||::||:.:|.|:||..|.::||..|.:||::. ..||...|
Human  1552 RTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK-DSVFASFV 1599

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	PLN03130	10..1289	CDD:215595	421/1479 (28%)
ABCC8	NP_001338224.1	MRP_assoc_pro	224..1600	CDD:188098	405/1410 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	957..1009		9/67 (13%)