DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC8

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_016873686.1	Gene:	ABCC8 / 6833	HGNCID:	59	Length:	1604	Species:	Homo sapiens

Alignment Length:	1480	Identity:	421/1480 - (28%)
Similarity:	703/1480 - (47%)	Gaps:	273/1480 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FSTLMFCFA--LPIL-------------------FKGRKKTLEPTDLYNALKEHKAETLGDKFFA 60
            ||.|.||..  |.||                   ||..::...|.||         :.||.:|..
Human   164 FSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYIFFKTPREVKPPEDL---------QDLGVRFLQ 219

  Fly    61 T-----------WQS-----------EVRSCGDSP--------------------KKE------- 76
            .           |.:           ::|:.|..|                    :|:
Human   220 PFVNLLSKGTYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCEAFDAQVRKDIQGTQGA 284

  Fly    77 PSIIRVILKVFGWQLFLSG---IVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTL 138
            .:|.:.:...||.:|.||.   |:..:|....    ||.:..::....:..:......|..|:..
Human   285 RAIWQALSHAFGRRLVLSSTFRILADLLGFAG----PLCIFGIVDHLGKENDVFQPKTQFLGVYF 345

  Fly   139 ILS-------ILFSVLMFHPLMMGLMHL----------AMKMRVAVSTAIYRKALRLSRT--ALG 184
            :.|       .:.:||:|..|::....|          .:.:|.|:.|.||.|.:.||.:  ::|
Human   346 VSSQEFLANAYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMG 410

  Fly   185 DTTTGQVVNLISNDLGRFDRALIHFHF----LWLGPLELLISSYFLYQQIGVASLYGIVILLLFL 245
            :.|.||:.||::.|..:    |:.|.|    ||..|:::::....||..:||::|.|..:::|..
Human   411 EMTAGQICNLVAIDTNQ----LMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLA 471

  Fly   246 PIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKV 310
            |:|.|::...|:.:..|...:::|::..||::.||:::|:|.||..|...:|..||.||:|:|..
Human   472 PVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFRTRVETTRRKEMTSLRAF 536

  Fly   311 NYIRGTLLSFEITLSRIAIFVSLLGFV--LMGGELTAERAFSVTAFYNILRRTVCKFF--PSGMS 371
            .......:.....:...|:.::.:|.|  ....:.:...||:..:.::||   |...|  .|.:.
Human   537 AIYTSISIFMNTAIPIAAVLITFVGHVSFFKEADFSPSVAFASLSLFHIL---VTPLFLLSSVVR 598

  Fly   372 QFAEMMVTLRRIKGFM----MRSETEALY--LKGGQTNK---LFEG------------------E 409
            ...:.:|:::::..|:    :|.|..|.:  ...|..:|   :.||                  :
Human   599 STVKALVSVQKLSEFLSSAEIREEQCAPHEPTPQGPASKYQAVEEGLPSLHSSQPSGSSPPNHPQ 663

  Fly   410 PL-----------------------------------VKLQSFQARWNHDHVEPVLENINISLSP 439
            ||                                   |::......|..|.: |.|.||.|.:..
Human   664 PLRVVNRKRPAREDCRGLTGPLQSLVPSADGDADNCCVQIMGGYFTWTPDGI-PTLSNITIRIPR 727

  Fly   440 PQLVAVIGPVGSGKSSLIQAILGELPGESG---------------------------KLKVQGDI 477
            .||..::|.||.|||||:.|.|||:...||                           .::.:|.:
Human   728 GQLTMIVGQVGCGKSSLLLAALGEMQKVSGAVFWSSSLPDSEIGEDPSPERETATDLDIRKRGPV 792

  Fly   478 SYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQR 541
            :||||:|||.||:|.:||:|..|.:|.||:.||..|:|:.|.::| |||:|.:||||.:||||||
Human   793 AYASQKPWLLNATVEENIIFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIGERGINLSGGQR 857

  Fly   542 ARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRD--KLVILVTHQLQFLEHADLI 604
            .|||:|||:|:.|:...||||.||:|.|:..||.:..:...|||  :.|:||||:||:|.|||.|
Human   858 QRISVARALYQHANVVFLDDPFSALDIHLSDHLMQAGILELLRDDKRTVVLVTHKLQYLPHADWI 922

  Fly   605 VIMDKGKISAVGTYEEMLKSG----QDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSS 665
            :.|..|.|...||.::..:|.    :.:..|:..:.||:                :|.|.:.:.:
Human   923 IAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQEL----------------EKETVTERKA 971

  Fly   666 RVSRVSVTSVDSSTESILDNERQPAQES-------------RSQGKIGLGIYGKYFSAGSGWLMV 717
            ......::...||.:.:|.:|.:..:|:             ..:.:|......||.|: :|.|::
Human   972 TEPPQGLSRAMSSRDGLLQDEEEEEEEAAESEEDDNLSSMLHQRAEIPWRACAKYLSS-AGILLL 1035

  Fly   718 ILVAFFCLGTQILASGGDYFLSYWVK--------------NNDSSSSTDIY--IFSGINAALVIF 766
            .|:.|..|...::....||:|:.|..              :.:.:....:|  :|:.:.:..::.
Human  1036 SLLVFSQLLKHMVLVAIDYWLAKWTDSALTLTPAARNCSLSQECTLDQTVYAMVFTVLCSLGIVL 1100

  Fly   767 ALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDC 831
            .|:.::......:..:.:||.::...:....:.||...|.|.|||||:.|...:|:.:|:. |:|
Human  1101 CLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCNTIDQHIPST-LEC 1164

  Fly   832 I--QIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSA 894
            :  ...|.:|. :.|:....|.:|:..:.:.:..:|::.::...||||::|:...:.|:.|||:.
Human  1165 LSRSTLLCVSA-LAVISYVTPVFLVALLPLAIVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAE 1228

  Fly   895 TLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLF--CVAYVISVTLMSYF 957
            |:.||:||||...:....::...|.|.::.......:.||.....::..  ||..:.:||.:|..
Human  1229 TVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANRWLEVRMEYIGACVVLIAAVTSISNS 1293

  Fly   958 NPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPP 1022
            .....:.|.:||.:|.|:.::..:.|.:|..|::|..:.:|:|:......|||...........|
Human  1294 LHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMELQLGAVKRIHGLLKTEAESYEGLLAPSLIP 1358

  Fly  1023 MNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYN 1086
            .|||.:|.|..:.||:||  |.....|||.:|.:|.|.:||||.||||:||||...|.||: ...
Human  1359 KNWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALIAPGQKIGICGRTGSGKSSFSLAFFRMVDTF 1421

  Fly  1087 EGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEV 1151
            ||.::||..||..:.||.|||::|||.|:|||||||:|.||||..:.:|..||||||...||..|
Human  1422 EGHIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRFNLDPERKCSDSTLWEALEIAQLKLVV 1486

  Fly  1152 SELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFR 1216
            ..||.||::::.|||.|:|.|||||.|||||.:|:..|.:||||||::|..|:.::|..:...|.
Human  1487 KALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIFIMDEATASIDMATENILQKVVMTAFA 1551

  Fly  1217 DCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMV 1266
            |.||:|||||::||:.:|.|:||..|.::||..|.:||::. ..||...|
Human  1552 DRTVVTIAHRVHTILSADLVIVLKRGAILEFDKPEKLLSRK-DSVFASFV 1600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	418/1469 (28%)
		ABC_membrane	92..362	CDD:294371	71/297 (24%)
		ABCC_MRP_domain1	412..611	CDD:213217	96/228 (42%)
		ABC_membrane	718..981	CDD:294371	62/282 (22%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	113/221 (51%)
ABCC8	XP_016873686.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151572
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2093
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.600