DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and abcc12

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_009301629.1	Gene:	abcc12 / 568482	ZFINID:	ZDB-GENE-050517-25	Length:	1368	Species:	Danio rerio

Alignment Length:	1346	Identity:	463/1346 - (34%)
Similarity:	741/1346 - (55%)	Gaps:	120/1346 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 TNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHK-AETLGDKFFATWQSEVRSCGD 71
            ::|.:.||.||...|.:..|::::..:..|:...|:  |..|. |...|::|...|..||...|.
Zfish    66 SHPVDDAGFFSFTSFSWMTPMMWRLFRNRLDEDSLF--LSPHDGAHINGERFQRLWDEEVARVGL 128

  Fly    72 SPKKEPSII------RVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLW 130
            ......::|      |.|:......:|...:.||          |.||...|..:........:
Zfish   129 EKASLSAVIMRFQKTRFIVSFLASVMFAFAVFVG----------PSILVYEILNYVEQSEPSTV- 182

  Fly   131 AQIYGLTLILSIL---FSVLMFHPLMMGL-MHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQV 191
              ::|:.:.:::.   ||...|..::..: :..|::::.|.|...::|.:.|  .:|...|.|:.
Zfish   183 --VHGVGVCVALFLTEFSKAFFASVLWAVNLRTAVRVKGAFSMLAFKKIISL--RSLTTITVGET 243

  Fly   192 VNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTS 256
            :|::::|..|...|:|...||...|:.|:|...:....:|..:|.||::.|:|||||..::||..
Zfish   244 INVLTSDGYRLFDAVIFGTFLLCVPVLLIICIIYACFILGYTALIGILVYLIFLPIQFSIARLIG 308

  Fly   257 RLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFE 321
            ..|.:....||:|||.|||:::.|::||||.||:.|.:.|..:|::|...::|..|::....|..
Zfish   309 VFRRRAVSVTDKRVRTMNEVLTCIKLIKMYAWEESFEKSITDIRKNEKLLLQKAGYVQSLNSSLT 373

  Fly   322 ITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGF 386
            ..:..:|..|:.:....:...|....|:::.|.:|.:|.:: ...|..:...||..|.|.|:|..
Zfish   374 TIVPTLATIVTFIVHTSLKLPLLPSTAYTIIAVFNCMRMSM-GLLPFSVKAVAEAKVALTRLKRI 437

  Fly   387 MMRSETEALYLKGGQTNKL--------FEGEPLVKLQSFQARWNHD-------HVEPVLENINIS 436
            |:....:. ||...:...|        |...|.....:.|...|..       ..:|.|.||:::
Zfish   438 MLVQNPKG-YLTQDKNMDLALVMEKATFSWSPTDDKNTSQMPENPSQNGKHKAESQPSLRNISLT 501

  Fly   437 LSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPM 501
            ||...|:.|.|.|||||:|||.:||.::...||.:...|.::|.||:.|:|:.:||||||.|.|.
Zfish   502 LSKGSLLGVCGNVGSGKTSLISSILEQMHLLSGSVSANGTLAYVSQQAWIFHGTVRDNILMGEPF 566

  Fly   502 DKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSA 565
            |:.||.:||..|.|:.|..:| :||:|.:||||.:|||||:.|:|||||||...|.:||||||||
Zfish   567 DEARYASVINACCLKPDLAILPYGDQTEIGERGINLSGGQKQRVSLARAVYSNRDIFLLDDPLSA 631

  Fly   566 VDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGK 630
            ||.|||:|:||||::..|:.|.|||||||||:||..|.::::|.|:|...||:.:::|:...:.:
Zfish   632 VDAHVGKHIFEECIKKELKGKSVILVTHQLQYLEFCDEVMLLDNGEIKEAGTHSDLMKTKGRYSQ 696

  Fly   631 LLATEAQEMGDSNQEQVNAEGDSR-----NDKSTYSRQSSRVSRVSVTSVDSSTESILDNE---- 686
            |:.       :.:.||.|...||:     ||....:....:.:.:...:.|.|.|....||
Zfish   697 LIT-------NVHLEQNNERADSKPQTEHNDSEQTNPDEPKANGIENPAFDMSDEKPATNETPKD 754

  Fly   687 -------------RQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASG--GDY 736
                         |:.|||    |.:....|.:|..|..|::::.||..  |.|.::.|.  .::
Zfish   755 SSETKGKKDQLVTREVAQE----GSVTWRTYHQYCQAAGGYILLFLVVL--LFTLLVGSTAFSNW 813

  Fly   737 FLSYWVK----NNDSSSST----------DI----YIFSGINAALVIFALLRTLLFFSMAMHSST 783
            :||||:.    ||.||::|          |:    .::..|..|:::.::|:...|..:.:.||:
Zfish   814 WLSYWLDQGSGNNSSSNATSNSGNISENPDLSFYQMVYGVIIIAMIVLSILKGYTFTKVTLRSSS 878

  Fly   784 QLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCIT 848
            :||:|||:.:..:.:.||...|:||::|||:.|..:||.:||..|.:.:|..|.::..:..:||.
Zfish   879 KLHDTMFKRILGSPMSFFDTTPTGRLVNRFSKDQDEVDAVLPFNMENFLQFCLIVTFTLLTICIV 943

  Fly   849 NPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTK 913
            .|:.||..:.:.|.|..:...:..:.|.:||:|.::|||..|..::|:.|||||.|.:.:....:
Zfish   944 FPFLLIAVVILGLIFATILYVFQRSIRHMKRMENVSRSPWISLTTSTIQGLSTIHAYDKRQQYIE 1008

  Fly   914 EYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNP-PVDNPGQIGLVITQAMSM 977
            .:....|.:|:.:..|.:..|...::||:......:.|:|....:| ...||...||.::..:.:
Zfish  1009 RFKMLSDNNSNHFMLFNAGTRWLSFWLDVLSATVTLIVSLFVVLSPNETINPSLKGLALSYTIQL 1073

  Fly   978 TGTVQWGMRQSAELENSMTSVERVLEY-RHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYN 1041
            ||.:|:.:|.|.|:|...|||||:||| ....:||. ....|...|..|||||.|:.:..|:||.
Zfish  1074 TGILQFVVRLSTEVEAKFTSVERLLEYITSCVSEGP-RRVKDANIPAGWPQEGTITFKNYSMRYR 1137

  Fly  1042 PDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSY-NEGSLVIDNTDILGIGLHDL 1105
            .:...  ||.:||..|.|.||:|||||||:|||||..|||||:. .||:::||:.||..:||.||
Zfish  1138 DNTPI--VLDNLNITIRPGEKLGIVGRTGSGKSSLGVALFRLAEPAEGTILIDDMDICKLGLKDL 1200

  Fly  1106 RSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYS 1170
            ||::|:|||:||||.||:|.|||||..|.||:||.|||:.::||.:|:||..|:|.|.|.|.|:|
Zfish  1201 RSQLSVIPQDPVLFIGTVRYNLDPFNNYKDEELWLALEKTYMKDTISKLPEKLQSPVVENGENFS 1265

  Fly  1171 VGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDR 1235
            ||:|||:|:|||:||.::|:::|||||::|.:||:|||.|||..|:.||:||||||:||:::|||
Zfish  1266 VGERQLMCMARALLRNSKIILLDEATASIDSETDSLIQHTIRDGFQHCTMLTIAHRINTVLESDR 1330

  Fly  1236 VMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLKLA 1281
            ::|:|.|.::||..|.:|             :|...|.|..||..|
Zfish  1331 ILVMDQGKVIEFDPPQDL-------------IQRPNSLFASLLAAA 1363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	457/1320 (35%)
		ABC_membrane	92..362	CDD:294371	71/273 (26%)
		ABCC_MRP_domain1	412..611	CDD:213217	100/206 (49%)
		ABC_membrane	718..981	CDD:294371	79/283 (28%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	123/221 (56%)
abcc12	XP_009301629.1	CFTR_protein	68..1366	CDD:273530	463/1344 (34%)
		ABC_membrane	149..414	CDD:294371	71/279 (25%)
		ABCC_MRP_domain1	457..677	CDD:213217	102/219 (47%)
		ABC_membrane	809..1077	CDD:294371	74/267 (28%)
		ABCC_MRP_domain2	1125..1345	CDD:213211	123/221 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586095
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	7	6.660