DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcb9

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_063928.2	Gene:	Abcb9 / 56325	MGIID:	1861729	Length:	762	Species:	Mus musculus

Alignment Length:	625	Identity:	160/625 - (25%)
Similarity:	285/625 - (45%)	Gaps:	126/625 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   717 VILVAFFCLGTQILASGGDYFLSYWV-KNNDS---SSSTDIYIFSGINAALVIFALLR------- 770
            ::..:||.    |:|:.|:.||.|:. :..||   ..|.|.:     ..|:|:..||.
Mouse   184 LVAASFFL----IVAALGETFLPYYTGRAIDSIVIQKSMDQF-----TTAVVVVCLLAIGSSLAA 239

  Fly   771 -------TLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVM 828
                   ||:|..:    :.:|.|.:|:.:......||..|.:|.:::|...|...|.:::.
Mouse   240 GIRGGIFTLVFARL----NIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVS--- 297

  Fly   829 LDCIQIFL----TISGIIGVLCITNPWYLINTITMFLAFHFLR-------TFYLSTSRDLKRLEA 882
             ..|.|||    .::|:: |...:..|.|  ::..|:.|..:.       .:|...|::::  .|
Mouse   298 -QNINIFLRNTVKVTGVV-VFMFSLSWQL--SLVTFMGFPIIMMVSNIYGKYYKRLSKEVQ--SA 356

  Fly   883 IARSPMYSHFSATLNGLSTIRAM-----EAQDLLTKEYDNYQ--DIHSSGYYTFLSTNRAFGYYL 940
            :||:...:  ..|::.:.|:|:.     ||:..|.|....|:  ...::.|.:::     :|..|
Mouse   357 LARASTTA--EETISAMKTVRSFANEEEEAEVFLRKLQQVYKLNRKEAAAYMSYV-----WGSGL 414

  Fly   941 DLFCVAYVISVTLMSYFNPPVDNPGQIG-----------LVITQAMSMTGTVQWGMRQSAELENS 994
            .|.    |:.|::: |:...:...||:.           .|:...|...|:|..|:.|      .
Mouse   415 TLL----VVQVSIL-YYGGHLVISGQMSSGNLIAFIIYEFVLGDCMESVGSVYSGLMQ------G 468

  Fly   995 MTSVERVLEYRHLEAEGEFESPDDKKPPMNW-----PQ--EGLISAEQLSLRYNPDPKADRVLKS 1052
            :.:.|:|.|:            .|::|.|..     |.  ||.:..|.::..|...|.. :||::
Mouse   469 VGAAEKVFEF------------IDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHT-QVLQN 520

  Fly  1053 LNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNEGSLVIDNTDILGIGLHD---LRSKISIIPQ 1114
            ::|.:.|.:...:||.:|:||||.:|.|......:|..|:  .|...||.:|   |...||::.|
Mouse   521 VSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLQGGRVL--LDGKPIGAYDHKYLHRVISLVSQ 583

  Fly  1115 EPVLFSGTLRCNLD------PFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQ 1173
            |||||:.::..|:.      |||...     ||.::.:....:.||.:|..:...|.|:..|.||
Mouse   584 EPVLFARSITDNISYGLPTVPFEMVV-----EAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQ 643

  Fly  1174 RQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMV 1238
            :|.|.:|||::|...:|::||||:.:|.:::.|||..|....:..|||.|||||:|:..:..::|
Mouse   644 KQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQRHTVLIIAHRLSTVERAHLIVV 708

  Fly  1239 LDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLL 1278
            ||.|.:|:.|:..:||.|..   .|..::|......||.|
Mouse   709 LDKGRVVQQGTHQQLLAQGG---LYAKLVQRQMLGLEHPL 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	154/602 (26%)
		ABC_membrane	92..362	CDD:294371
		ABCC_MRP_domain1	412..611	CDD:213217
		ABC_membrane	718..981	CDD:294371	64/309 (21%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	77/229 (34%)
Abcb9	NP_063928.2	3a01208	44..734	CDD:273363	156/612 (25%)
		ABC_membrane	189..451	CDD:279056	61/295 (21%)
		ABCC_TAP	489..714	CDD:213215	77/232 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000