DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and abcc9

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_005164758.1	Gene:	abcc9 / 561160	ZFINID:	ZDB-GENE-050517-23	Length:	1583	Species:	Danio rerio

Alignment Length:	1390	Identity:	421/1390 - (30%)
Similarity:	706/1390 - (50%)	Gaps:	168/1390 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 IFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAET----LGDKFFATWQSEVRSCGDSPKKE 76
            :.|...:.:..|::....|:.:|...:.......:|.|    |.|.:     .|.|...:.|:|.
Zfish   224 LLSKATYWWMNPLIIGAHKRPIELKKIGKLPIAMRALTNYLRLKDSY-----EEQRQNTEDPEKS 283

  Fly    77 PSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALI------AEFTRNGNGDGLWAQIYG 135
            |||.:.:.:.||..:.||.....:.:|...|. ||.:..::      .|..|......:...:|.
Zfish   284 PSIWKSMYRAFGGSILLSSTFRYMADLLGFAG-PLCISGIVEHLHNSTEIDRTNKTGNMTFGVYF 347

  Fly   136 LT----LILSILFSVLMFHPLMMGLMHL----------AMKMRVAVSTAIYRKALRLSRT--ALG 184
            ::    |..:.:.:||:|..|::....|          .:.:|.|:...||.|.||||.:  ::|
Zfish   348 MSSTELLQNTSVLAVLLFLALVLQRTFLQASYYVTIETGINLRGALLAMIYNKILRLSTSNMSMG 412

  Fly   185 DTTTGQVVNLISNDLGRFDRALIHFHF----LWLGPLELLISSYFLYQQIGVASLYGIVILLLFL 245
            :.|.||:.||::.:..:    |:.|.|    ||..|:::::....||..:|.::|.|..::||..
Zfish   413 EMTLGQINNLVAIETNQ----LMWFLFLCPNLWAMPVQIIMGVILLYYLLGNSALIGAGVILLLA 473

  Fly   246 PIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKV 310
            |:|..::...:.::..|...:..|::...||:.||:::|:|.||..|...:|..|..|::|::
Zfish   474 PVQYLIATKLADIQKSTLDYSTDRLKKTTEILKGIKLLKLYAWENIFCDRVEETRGKELTSLK-- 536

  Fly   311 NYIRGTLLSFEITLSRIAIFVSLLGFV----LMGGELTAERAFSVTAFYNILRRTVCKFFPSGMS 371
            .:...|.:|..:. :.|.|...|..||    :....|:..:||:..|.::||...:  |..|.:.
Zfish   537 TFALHTSMSIFMN-AAIPIAAVLATFVTHAYIEEDRLSPAKAFASLALFHILVTPL--FLLSTVV 598

  Fly   372 QFA-EMMVTLRRIKGFMM---------RSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHV 426
            :|| :.:|:::::..|:.         |:....:.|:.|:..| ::|:  .|..:.:.|:..|:.
Zfish   599 RFAVKALVSVQKLSEFLQSDEIGDDSWRNGDMCMSLEVGKKYK-YQGD--TKAINRKGRYRMDNY 660

  Fly   427 E-PV-----------------------------LENINISLSPPQLVAVIGPVGSGKSSLIQAIL 461
            | ||                             |.:|||.:...||..::|.||.|||||:.|:|
Zfish   661 EQPVRRQLRPSETEDVAVQVNDGFFTWGSNLSTLSDINIRIPTGQLTMIVGQVGCGKSSLLLAML 725

  Fly   462 GELPGESGKL-----------------------------KVQGDISYASQEPWLFNASVRDNILF 497
            ||:...|||:                             |.:..::||:|:.||.||:|.:||.|
Zfish   726 GEMQTISGKVYWSKLPDCEILFDGNISGHDMELSHEERSKNRYSVAYATQKSWLLNATVEENITF 790

  Fly   498 GLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDD 561
            |.|.:|.||:.||..|:|:.|.:|| .||:|.:||||.:||||||.||.:|||:|:..:...|||
Zfish   791 GSPFNKQRYKAVIDACSLQPDIDLLPFGDQTEIGERGINLSGGQRQRICVARALYQNTNIVFLDD 855

  Fly   562 PLSAVDTHVGRHLFEECMRGFLRD--KLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEM--- 621
            |.||:|.|:..||.:|.:..||:|  :.|:||||:||:|.|||.|:.|..|.:...||.:::
Zfish   856 PFSALDIHLSDHLMQEGILKFLQDDKRTVVLVTHKLQYLIHADWIIAMKDGSVLREGTLKDIQTH 920

  Fly   622 -LKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQ-SSRVSRVSVTSVDSSTESILD 684
             ::..:.:..|:..:.||:    ::..:.|..:..::.|..|. .||.::..|...|...|...:
Zfish   921 DVELYEHWKTLMNRQDQEL----EKDTDLESQTTLERKTLRRAFYSREAKNHVDDEDEEEEVEEE 981

  Fly   685 NERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSS 749
            ::...:..:..:.||...:...|.|:| |:|||.|:....|....:....||:|:.|..:|..:.
Zfish   982 DDDNMSTTTSRRSKIPWKMCCCYLSSG-GFLMVFLMVSSKLAKHSVMVAIDYWLAAWTSSNPHNQ 1045

  Fly   750 STDIYIFSGIN------------------------AALVIFALLRTLLFFSMAMHSSTQLHNTMF 790
            |   ::.|..|                        ||.:...|:.:|....:.:.::|.||:.:.
Zfish  1046 S---FVNSSFNHTLNDDATQIAEHRSYVPVFIILCAAAIALCLITSLTVEFLGVAAATNLHHNLL 1107

  Fly   791 QGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLIN 855
            ..:....:.||...|.|:|||||:.|...:|:.:|..:....:..|.....|||:....|.:||.
Zfish  1108 NKIIHAPIRFFDVTPLGQILNRFSADTNIIDQHIPPTLESLTRSTLLCLSAIGVIAFVTPAFLIA 1172

  Fly   856 TITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQD 920
            .:.:.:||:|::.::...|:||:.|:...:.|:..|||.|..||:||||...:....:......|
Zfish  1173 LVPLAVAFYFIQKYFRVASKDLQELDDSTQLPLLCHFSETAEGLTTIRAFRHEARFKQRMLELTD 1237

  Fly   921 IHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGM 985
            .:::.|....:.||......|......|::..:.:.::  ....|.:||.:|.|:::|..:.|.:
Zfish  1238 TNNTAYLFLSAANRWLEVRTDYLGAVIVLTAAVAAIWS--TSPSGLVGLGLTYALTLTNYLNWVV 1300

  Fly   986 RQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVL 1050
            |..|:||..|.:|::|..:...|:|....|.|..:.|.:|||.|.|:...|.:||  |.....||
Zfish  1301 RNLADLEVQMAAVKKVNSFLSTESENYEGSMDVSQVPEDWPQHGEITIHDLCVRY--DSMLKPVL 1363

  Fly  1051 KSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQ 1114
            |.:|..|.|.:|:||.||||:|||||..|.|.: ...||.:|||..||..:.|..|||::|||.|
Zfish  1364 KHVNAHINPGQKVGICGRTGSGKSSLSLAFFNMVDVFEGKIVIDGIDICKLPLQTLRSRLSIILQ 1428

  Fly  1115 EPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCL 1179
            :||||||::|.||||.....|::||||||...||:.|..||.||::||.|||.|:|||||||.||
Zfish  1429 DPVLFSGSIRLNLDPERTCTDDRLWEALEIAQLKNMVKALPGGLDAVVTEGGENFSVGQRQLFCL 1493

  Fly  1180 ARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTL 1244
            |||.:|::.||:||||||::|..|:.::|..:...|.|.||:||||.:::|:::::|:|..:|.|
Zfish  1494 ARAFVRKSSILIMDEATASIDMATENILQKVVMTAFADRTVVTIAHLVSSILEAEQVLVFSSGIL 1558

  Fly  1245 VEFGSPFELLTQSWSKVFYGMVLQT 1269
            ||..|...||.|..|  .:|::::|
Zfish  1559 VENDSAINLLAQEDS--LFGILVRT 1581

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	417/1376 (30%)
		ABC_membrane	92..362	CDD:294371	73/299 (24%)
		ABCC_MRP_domain1	412..611	CDD:213217	97/260 (37%)
		ABC_membrane	718..981	CDD:294371	66/286 (23%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	111/221 (50%)
abcc9	XP_005164758.1	CFTR_protein	223..1575	CDD:273530	419/1382 (30%)
		ABC_membrane	304..591	CDD:294371	71/294 (24%)
		ABCC_SUR1_N	678..907	CDD:213257	91/228 (40%)
		ABC_membrane	1045..1300	CDD:294371	60/259 (23%)
		ABCC_SUR2	1269..1583	CDD:213255	140/319 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586002
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.650