DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_016878726.1	Gene:	ABCC1 / 4363	HGNCID:	51	Length:	1549	Species:	Homo sapiens

Alignment Length:	1353	Identity:	483/1353 - (35%)
Similarity:	734/1353 - (54%)	Gaps:	124/1353 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE--------- 65
            |..||...|.:.|.:...::.:|.::.||.:||::..||..:|.:.......|:.|
Human   227 PESSASFLSRITFWWITGLIVRGYRQPLEGSDLWSLNKEDTSEQVVPVLVKNWKKECAKTRKQPV 291

  Fly    66 --VRSCGD----------------------SPKKE--PSIIRVILKVFGWQLFLSGIVVGVLELG 104
              |.|..|                      ||:||  ||:.:|:.|.||....:|.....:.:|
Human   292 KVVYSSKDPAQPKESSKVDANEEVEALIVKSPQKEWNPSLFKVLYKTFGPYFLMSFFFKAIHDL- 355

  Fly   105 TRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVST 169
            ...:.|.||..|| :|..:..........|.:.|.::.....|:.|..........|:::.||..
Human   356 MMFSGPQILKLLI-KFVNDTKAPDWQGYFYTVLLFVTACLQTLVLHQYFHICFVSGMRIKTAVIG 419

  Fly   170 AIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVAS 234
            |:|||||.::.:|...:|.|::|||:|.|..||.....:.:.:|..||:::::.|.|:..:|.:.
Human   420 AVYRKALVITNSARKSSTVGEIVNLMSVDAQRFMDLATYINMIWSAPLQVILALYLLWLNLGPSV 484

  Fly   235 LYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERL 299
            |.|:.:::|.:|:...::..|...:.......|.|:::||||::||:|:|:|.||..|...:..:
Human   485 LAGVAVMVLMVPVNAVMAMKTKTYQVAHMKSKDNRIKLMNEILNGIKVLKLYAWELAFKDKVLAI 549

  Fly   300 RRSEMSSIRKVNYIR--GTL----LSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNIL 358
            |:.|:..::|..|:.  ||.    ..|.:.|...|::|:    :.....|.|:.||...|.:|||
Human   550 RQEELKVLKKSAYLSAVGTFTWVCTPFLVALCTFAVYVT----IDENNILDAQTAFVSLALFNIL 610

  Fly   359 RRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLK------GGQTNKLFEGEPLVKLQSF 417
            |..: ...|..:|...:..|:|:|::.|:...|.|...::      ||.||.:     .|:..:|
Human   611 RFPL-NILPMVISSIVQASVSLKRLRIFLSHEELEPDSIERRPVKDGGGTNSI-----TVRNATF 669

  Fly   418 QARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQ 482
              .|.... .|.|..|..|:....||||:|.||.|||||:.|:|.|:....|.:.::|.::|..|
Human   670 --TWARSD-PPTLNGITFSIPEGALVAVVGQVGCGKSSLLSALLAEMDKVEGHVAIKGSVAYVPQ 731

  Fly   483 EPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISL 546
            :.|:.|.|:|:|||||..:::..||:||:.|||..|.|:| .||||.:||:|.:|||||:.|:||
Human   732 QAWIQNDSLRENILFGCQLEEPYYRSVIQACALLPDLEILPSGDRTEIGEKGVNLSGGQKQRVSL 796

  Fly   547 ARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDK 609
            |||||..||.||.||||||||.|||:|:||..:  :|.|::|..|||||.:.:|...|:|::|..
Human   797 ARAVYSNADIYLFDDPLSAVDAHVGKHIFENVIGPKGMLKNKTRILVTHSMSYLPQVDVIIVMSG 861

  Fly   610 GKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSS--------- 665
            ||||.:|:|:|:|.....|.:.|.|.|....:.:.|:....|.|...|.....::.
Human   862 GKISEMGSYQELLARDGAFAEFLRTYASTEQEQDAEENGVTGVSGPGKEAKQMENGMLVTDSAGK 926

  Fly   666 ----RVSRVSVTSVDSSTESILDNERQPAQESRSQ------------GKIGLGIYGKYFSAGSGW 714
                ::|..|..|.|.|.......|.|.|:..:.:            |::.|.:|..|..| .|.
Human   927 QLQRQLSSSSSYSGDISRHHNSTAELQKAEAKKEETWKLMEADKAQTGQVKLSVYWDYMKA-IGL 990

  Fly   715 LMVILVAFFCLGTQILASGGDYFLSYWVKN---NDSSSST----DIYIFSGINAALVIFALLRTL 772
            .:..|..|..:...:.|...:|:||.|..:   |.:...|    .:|...||:..:.:|.
Human   991 FISFLSIFLFMCNHVSALASNYWLSLWTDDPIVNGTQEHTKVRLSVYGALGISQGIAVFG----- 1050

  Fly   773 LFFSMAMH-----SSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCI 832
              :|||:.     :|..||..:...:.|:.:.||...|||.::|||:.:|..||.::|.|    |
Human  1051 --YSMAVSIGGILASRCLHVDLLHSILRSPMSFFERTPSGNLVNRFSKELDTVDSMIPEV----I 1109

  Fly   833 QIFL-TISGIIG---VLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFS 893
            ::|: ::..:||   |:.:..|...|....:.|.:.|::.||:::||.|||||:::|||:||||:
Human  1110 KMFMGSLFNVIGACIVILLATPIAAIIIPPLGLIYFFVQRFYVASSRQLKRLESVSRSPVYSHFN 1174

  Fly   894 ATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFN 958
            .||.|:|.|||.|.|:....:.|...|.:...||..:..||.....|:......|:...|.:..:
Human  1175 ETLLGVSVIRAFEEQERFIHQSDLKVDENQKAYYPSIVANRWLAVRLECVGNCIVLFAALFAVIS 1239

  Fly   959 PPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPM 1023
            ....:.|.:||.::.::.:|..:.|.:|.|:|:|.::.:|||:.||...|.|..::. .:..||.
Human  1240 RHSLSAGLVGLSVSYSLQVTTYLNWLVRMSSEMETNIVAVERLKEYSETEKEAPWQI-QETAPPS 1303

  Fly  1024 NWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYN-E 1087
            :|||.|.:......|||..|  .|.||:.:|..|...||:|||||||||||||...|||::.: |
Human  1304 SWPQVGRVEFRNYCLRYRED--LDFVLRHINVTINGGEKVGIVGRTGAGKSSLTLGLFRINESAE 1366

  Fly  1088 GSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVS 1152
            |.::||..:|..|||||||.||:||||:||||||:||.|||||.||:||::|.:||..||||.||
Human  1367 GEIIIDGINIAKIGLHDLRFKITIIPQDPVLFSGSLRMNLDPFSQYSDEEVWTSLELAHLKDFVS 1431

  Fly  1153 ELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRD 1217
            .||:.|:...||||.|.|||||||||||||:||:.:|||:|||||.||.:||.|||||||.:|.|
Human  1432 ALPDKLDHECAEGGENLSVGQRQLVCLARALLRKTKILVLDEATAAVDLETDDLIQSTIRTQFED 1496

  Fly  1218 CTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            |||||||||||||:|..||:|||.|.:.|:|:|.:||.|  ..:||.|....|
Human  1497 CTVLTIAHRLNTIMDYTRVIVLDKGEIQEYGAPSDLLQQ--RGLFYSMAKDAG 1547

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	478/1338 (36%)
		ABC_membrane	92..362	CDD:294371	75/275 (27%)
		ABCC_MRP_domain1	412..611	CDD:213217	95/201 (47%)
		ABC_membrane	718..981	CDD:294371	80/278 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	138/221 (62%)
ABCC1	XP_016878726.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151521
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.660