DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and CG11898

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_651679.2	Gene:	CG11898 / 43451	FlyBaseID:	FBgn0039645	Length:	1320	Species:	Drosophila melanogaster

Alignment Length:	1339	Identity:	524/1339 - (39%)
Similarity:	776/1339 - (57%)	Gaps:	98/1339 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGD 71
            |.||...|..||...|.:...||.||.::.|:|:|||......::..:.......|:.|::
  Fly     9 QPNPVTKANFFSKWFFIWTREILVKGLQRNLDPSDLYETEPSLESTQVSSFLLGHWEQELK---- 69

  Fly    72 SPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRN-GNGDGLWAQIYG 135
              :.:|:::|:|.|.:||....:.||..::.:....|.||:||.|::.|:.: |......|.:|.
  Fly    70 --RSKPNVLRMIFKAYGWSFVPASIVYSIMAIAVHTTQPLMLGGLVSFFSESTGKITKHSAYLYA 132

  Fly   136 LTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLG 200
            :.::|..|.|.|.|||.|..|..:..::|:|.:..:|||.||:|..|.....:|..::|::.||.
  Fly   133 MGVVLCSLISGLFFHPFMKYLFRVGSRVRLACAGLVYRKFLRVSVAADNSGVSGYAISLMATDLP 197

  Fly   201 RFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALR 265
            .|:.:...||.||.||||.::..|.:||.||..::.|:..::.|:|:|.:.:|..:|.:..:|..
  Fly   198 TFNESFYCFHELWRGPLEGVVFVYIIYQLIGWPAVVGLGTIVAFIPLQAWAARAIARYKRSSADV 262

  Fly   266 TDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEIT--LSRIA 328
            .|:||::|||||:.:|:||||.|||.|.:||.::|:.||.|||...||...|   :.|  :|:::
  Fly   263 GDERVKLMNEIIAAMQLIKMYAWEKSFAKLIGKVRKEEMDSIRGSTYIYAGL---QCTGMISKLS 324

  Fly   329 IFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETE 393
            :|:||:.:|..|..:|:::.|.|.::|:.|..::...:|..::.:.|..|...|:|.|:.:.|..
  Fly   325 LFLSLVTYVFTGDIVTSQKVFIVASYYDHLNDSLLHSWPLAINMWVETFVVANRVKDFLFQHENP 389

  Fly   394 ALYLKGGQTN-KLFEGEP-----------------LVKLQSFQARWN-------HDHVEPVLENI 433
            |   .||..| |..|..|                 .:.:....|.|:       |.|:    |::
  Fly   390 A---DGGVHNFKEAEDNPEHGNFFGRTHKPKAEVKSITVHKLSASWDQKKQEKRHRHI----EDV 447

  Fly   434 NISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFG 498
            :......|.|.::|.||:|||:|:|.|||||...||.::|.|.:|||.|||||...|:||||||.
  Fly   448 SFQAQDQQFVGIVGTVGAGKSTLLQVILGELDIISGSVEVNGVLSYAPQEPWLLRGSLRDNILFT 512

  Fly   499 LPMDKHRYRNVIRNCALERDFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDP 562
            .|.|:.||..|:|.|.|:||.|.|. ||.|.|||.||||||||:||:||||||||:||.||||||
  Fly   513 EPYDEQRYLEVLRVCHLDRDVEQLPLGDSTRVGEGGASLSGGQKARVSLARAVYRKADIYLLDDP 577

  Fly   563 LSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQD 627
            |||||:||.:.|.:.|:..||..|:.|||||::|.|.|.|.:|:::.|:||..|.|:.:
  Fly   578 LSAVDSHVSKMLLDRCLNEFLSKKIRILVTHRVQLLRHVDHLVLLEGGRISVQGHYDAL------ 636

  Fly   628 FGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNE--RQPA 690
             .||:..   .|..:|..:|......|.| |.|.....|.|        .|.|..:|..  .|..
  Fly   637 -KKLIRF---RMSVANDVEVAKLRAMRTD-SVYEEPEPRKS--------LSQEEHMDRHEIEQQF 688

  Fly   691 QESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTD--- 752
            :|.:..|.:.|..|.:||......|:|:|:....:..:...:..|.|||.|....::..:..
  Fly   689 KEQQQIGSVKLQTYKEYFKVLGHPLVVVLILLMFVVARSSEATMDIFLSKWATWEETEPNQHEPI 753

  Fly   753 ----------IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSG 807
                      :.:::.:....:||.:|||..||.|.:..|.::|:.:||||.|..::||....||
  Fly   754 PEYHRTRLRMMILYTFLILCTLIFYVLRTFGFFMMTLRISLRIHDQLFQGVIRAFMHFFTLATSG 818

  Fly   808 RILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLS 872
            ||||||:.|:..:|..||..|:|.|:..:....::.|:...|.|.||....:....:..|..|:.
  Fly   819 RILNRFSSDVLAIDVNLPQAMMDSIEFAVNALAVLAVVSTANIWLLIPATVVVALLYGCRCLYIG 883

  Fly   873 TSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFG 937
            .||.|||:|.|:|||:|||.:||..||:||||:.....:.:::..||:.::|..|..:|.||||.
  Fly   884 ASRSLKRIETISRSPIYSHTNATFKGLATIRALNGTKYMERDFHYYQNENTSALYLHVSINRAFA 948

  Fly   938 YYLDLFCVAYVISVTL--------MSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENS 994
            ::.||.||.|:::||.        ..|::      |.:||.|||:|.:....|.||||:.||||.
  Fly   949 FWTDLICVLYILAVTFSFLLFDKHRGYYS------GDVGLAITQSMKLVLMCQAGMRQTVELENM 1007

  Fly   995 MTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRY-NPDPKADRVLKSLNFIIM 1058
            |||||||:||.::.:|..:|:.:....|.:||..|.:....|.||| |..|   .:||.|.|.|.
  Fly  1008 MTSVERVMEYVNIPSEPAYETEESVNLPKHWPSGGQLDFRDLRLRYSNHGP---YILKGLTFTIR 1069

  Fly  1059 PREKIGIVGRTGAGKSSLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTL 1123
            ..|||||||.|.|||||:::|||||::..|.:.||..:...:||||||.:||||||:||||||:|
  Fly  1070 GEEKIGIVGHTAAGKSSIVHALFRLAHINGHISIDGFETSQLGLHDLRRRISIIPQDPVLFSGSL 1134

  Fly  1124 RCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENR 1188
            |.||||||:..||:||.|||.|.||:.||.|.:|:...:.:.|:|:|:|||||||||||:||:|:
  Fly  1135 RFNLDPFEEKTDEELWLALEAVKLKEFVSNLKDGINCRLHDCGANFSMGQRQLVCLARALLRQNK 1199

  Fly  1189 ILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFEL 1253
            ||:||||||||||:||.|||..|..||..||||||||||:|::|:|||||:|.|.:||.|.|.||
  Fly  1200 ILIMDEATANVDPETDNLIQEAIHTKFAHCTVLTIAHRLHTVMDNDRVMVVDMGRVVELGHPHEL 1264

  Fly  1254 LTQSWSKVFYGMVLQTGRSSFEHLLKLALEAHERRLLSQ 1292
            | .:.....:..|.:||..:.:||..||.:::.:|:|.:
  Fly  1265 L-HNRHGYLHRFVEKTGVGTAQHLRHLAEQSYRKRVLGR 1302

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	515/1302 (40%)
		ABC_membrane	92..362	CDD:294371	95/272 (35%)
		ABCC_MRP_domain1	412..611	CDD:213217	105/206 (51%)
		ABC_membrane	718..981	CDD:294371	90/283 (32%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	132/221 (60%)
CG11898	NP_651679.2	CFTR_protein	9..1268	CDD:273530	515/1303 (40%)
		ABC_membrane	92..358	CDD:294371	95/268 (35%)
		ABCC_MRP_domain1	423..626	CDD:213217	105/206 (51%)
		ABC_membrane	762..988	CDD:294371	83/231 (36%)
		ABCC_MRP_domain2	1042..1261	CDD:213211	132/221 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440892
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm14754
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	10	9.800