DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Mrp4

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_650086.2	Gene:	Mrp4 / 41387	FlyBaseID:	FBgn0263316	Length:	1316	Species:	Drosophila melanogaster

Alignment Length:	1312	Identity:	810/1312 - (61%)
Similarity:	1014/1312 - (77%)	Gaps:	35/1312 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE 65
            |:|.:|..||||.:...|:||||||||:||||||||||..|||.||||||:::|||:..|.|..:
  Fly     4 MKADELPENPRERSSPLSSLMFCFALPVLFKGRKKTLEQKDLYRALKEHKSDSLGDRLCAAWDEQ 68

  Fly    66 VRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLW 130
            |     :..:.|.:.|.:.||||:.||::|:.:...|..|:.|.|:.|..::|.|..| :.|...
  Fly    69 V-----AKNETPRLGRALTKVFGFHLFITGVFLLAQEFLTKVTQPICLIGVMAYFAGN-DPDRSK 127

  Fly   131 AQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLI 195
            ||::...||...:|||.:.||.|:||:||.||||:|:|:.|||||||||||||||||.||||||:
  Fly   128 AQLWAAGLIAGSVFSVCIGHPYMLGLLHLGMKMRIALSSLIYRKALRLSRTALGDTTVGQVVNLL 192

  Fly   196 SNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRH 260
            |||:||||..||:.|:||:.||||:..:|.:|.:||::|::|:.|:|||||.|::|.:.||.||.
  Fly   193 SNDVGRFDLVLINVHYLWIAPLELIAVTYLMYLEIGISSMFGVAIMLLFLPFQSYLGKRTSVLRL 257

  Fly   261 QTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLS 325
            :||||||:||||||||||||||||||.||||||:::|..|.:||..|::||||||.|:||.:.||
  Fly   258 RTALRTDERVRMMNEIISGIQVIKMYAWEKPFGKVVEMTRFNEMLCIKQVNYIRGILISFAMFLS 322

  Fly   326 RIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRS 390
            ||....||:.|||:|..|.||:||.|||:||||||:|..|||.|:|:|||::|::||::.||.|.
  Fly   323 RIFTSSSLIAFVLLGNILNAEKAFFVTAYYNILRRSVTMFFPQGISEFAELLVSVRRLEAFMHRP 387

  Fly   391 ETEAL-YLKGGQTNKLFEG------------EPLVKLQSFQARWNHDHVEPVLENINISLSPPQL 442
            ||:.. ..|....|:..|.            |.|::...|||||....:||.||:||:.|...:|
  Fly   388 ETKVRDKSKVKNANQKAESPNGDSPKGNGIPENLIEFSQFQARWESHSLEPTLEDINLQLGRRKL 452

  Fly   443 VAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYR 507
            ||||||||:||||||||||||||||||.|::.|..|||:||||||..:||.||||||..||||||
  Fly   453 VAVIGPVGAGKSSLIQAILGELPGESGTLRINGSYSYAAQEPWLFTGTVRQNILFGLDWDKHRYR 517

  Fly   508 NVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVG 571
            .|::.|||||||||| .||:|.||||||||||||:|||||||||||:||.|||||||||||||||
  Fly   518 TVVKKCALERDFELLPFGDKTIVGERGASLSGGQKARISLARAVYRRADIYLLDDPLSAVDTHVG 582

  Fly   572 RHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEA 636
            ||||::||||:||.:|||||||||||||.||||||||||:|||:|||..|.:||.||.:||....
  Fly   583 RHLFDQCMRGYLRSELVILVTHQLQFLEQADLIVIMDKGRISAMGTYSSMKRSGLDFAQLLTAPN 647

  Fly   637 QEMGDSNQEQVNAEGDSRN--DKSTYSRQSSRVSRVSV-----TSVDSSTESILDNERQPAQESR 694
            ::..|.: |...|.||..:  :..:.||:.|:.|:.|.     ||:.|..||:........||:|
  Fly   648 KDAEDLD-EIDGAGGDGLDLLNVPSLSRRGSKNSKPSTRNNSFTSLSSMAESMAQEASLQMQETR 711

  Fly   695 SQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWV-KNND-----SSSSTDI 753
            .:||||||:|.:|.::||.|.|:..:.|.||.||||.|..|||||||| ||.|     ::...|:
  Fly   712 VEGKIGLGLYKEYLTSGSSWFMIFFMVFLCLATQILCSAADYFLSYWVDKNVDGQTDINTDPQDM 776

  Fly   754 YIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLG 818
            |.|:.:|.|:|:|.::||:||:.|||.|||||||.|:||::|.|:|||:.||||||||||:.|||
  Fly   777 YYFAALNVAVVVFTIVRTMLFYKMAMRSSTQLHNAMYQGITRAAMYFFNTNPSGRILNRFSKDLG 841

  Fly   819 QVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAI 883
            |:||:||:||||.:|:|||:.|||.|:|||||:|||.|:.:.:.|:::|.|||.||||:|||||:
  Fly   842 QLDEVLPSVMLDVVQLFLTLLGIIVVICITNPYYLILTLALAIIFYYIREFYLKTSRDVKRLEAV 906

  Fly   884 ARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYV 948
            ||||:|||.|||:.||.||||:.||..|..|:||.||:|||||||||:||||||||||.||..|:
  Fly   907 ARSPIYSHLSATITGLPTIRALGAQKELIAEFDNLQDLHSSGYYTFLATNRAFGYYLDCFCTLYI 971

  Fly   949 ISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEF 1013
            :.:.|..:.||| .:||::||.|||||.|||.|||.|||||||||:||:||||:||..:|.||||
  Fly   972 VIIILNYFINPP-QSPGEVGLAITQAMGMTGMVQWAMRQSAELENTMTAVERVVEYDEIEPEGEF 1035

  Fly  1014 ESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLIN 1078
            :|.:.|||..:||::|.|.||.|.|||.|||:|..|||:|||.|.|.||:|||||||||||||||
  Fly  1036 DSREGKKPSPSWPEKGEIIAEDLCLRYFPDPQAKYVLKALNFRIRPCEKVGIVGRTGAGKSSLIN 1100

  Fly  1079 ALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALE 1143
            ||||||||||.:.||..|...:||.||||||||||||||||||::|.||||||:|.|.|||:|||
  Fly  1101 ALFRLSYNEGIITIDERDTADMGLFDLRSKISIIPQEPVLFSGSMRYNLDPFEEYNDAKLWDALE 1165

  Fly  1144 EVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQ 1208
            ||.||..:|||||||:|.::|||||:|||||||||||||||||||:|||||||||||||||||||
  Fly  1166 EVKLKPLISELPNGLQSKISEGGSNFSVGQRQLVCLARAILRENRVLVMDEATANVDPQTDALIQ 1230

  Fly  1209 STIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSS 1273
            :|||.|||||||||||||||||:|||||:|:|||.|||||||:||||.|.||:|:|||::||:::
  Fly  1231 ATIRSKFRDCTVLTIAHRLNTIMDSDRVLVMDAGHLVEFGSPYELLTSSESKIFHGMVMETGQNT 1295

  Fly  1274 FEHLLKLALEAH 1285
            |:.|||:|.:||
  Fly  1296 FDSLLKVAEKAH 1307

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	792/1277 (62%)
		ABC_membrane	92..362	CDD:294371	156/269 (58%)
		ABCC_MRP_domain1	412..611	CDD:213217	150/199 (75%)
		ABC_membrane	718..981	CDD:294371	163/268 (61%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	174/220 (79%)
Mrp4	NP_650086.2	CFTR_protein	12..1277	CDD:273530	789/1272 (62%)
		ABC_membrane	93..359	CDD:294371	155/266 (58%)
		ABCC_MRP_domain1	422..622	CDD:213217	150/199 (75%)
		ABC_membrane	735..978	CDD:294371	148/242 (61%)
		ABCC_MRP_domain2	1051..1272	CDD:213211	174/220 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440873
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810