DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCC6

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_024306029.1	Gene:	ABCC6 / 368	HGNCID:	57	Length:	1515	Species:	Homo sapiens

Alignment Length:	1328	Identity:	427/1328 - (32%)
Similarity:	691/1328 - (52%)	Gaps:	89/1328 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 QTNP-RESAGIF-STLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATW---QSEV 66
            |:|| .|:...| |...|.:...::::|.::.|.|.||::..:|:.:|.|..:....|   :|..
Human   211 QSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 275

  Fly    67 R-------------SCGDSPKKEP------SIIRVILKVFGWQLFLSGIVVGVLEL----GTRAT 108
            |             |...:|:.||      |..|.:||.. ||:|.|..::|.|.|    ..|.|
Human   276 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAI-WQVFHSTFLLGTLSLIISDVFRFT 339

  Fly   109 LPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYR 173
            :|.:| :|..||..:.........:..:.:.||.....|.....|..|..|.|::|.|::..:||
Human   340 VPKLL-SLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYR 403

  Fly   174 KALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGI 238
            |.|.||..:...:..|.||||:|.|:.|...::::.:.|||..:.:::...:|:|.:|.::|..|
Human   404 KVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAI 468

  Fly   239 VILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSE 303
            .:.|..||:..|:|:..:..:.:...:.|.|.|:.:.|:...:.||.:.||..|...:..:|..|
Human   469 AVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQE 533

  Fly   304 MSSIRKVNYIRG-TLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFP 367
            :.::|....:.. :|:||:::...:|:.|..:..::....:.||:||......|||.:... |.|
Human   534 LGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQA-FLP 597

  Fly   368 SGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLEN 432
            ..:....:..|:..|:..|:...|.:...:....:... .|:..:.:.|....|:.:. .|.|..
Human   598 FSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSA-AGKDCITIHSATFAWSQES-PPCLHR 660

  Fly   433 INISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILF 497
            ||:::....|:||:||||:|||||:.|:||||....|.:.::|.::|..||.|:.|.||.:|:.|
Human   661 INLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCF 725

  Fly   498 GLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDD 561
            |..:|......|:..|||:.|.:.. .|..|.:||:|.:|||||:.|:||||||||:|..|||||
Human   726 GQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDD 790

  Fly   562 PLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKS 624
            ||:|:|.|||:|:|.:.:  .|.|:....|||||.|..|..||.|:::..|.|:.:|:|:|:|
Human   791 PLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL-- 853

  Fly   625 GQDFGKL--LATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRV-SVTSV--------DSS 678
             |..|.|  |..:|::.||..:.:......:::.:.|.:.:...:.|. |:.||        ::.
Human   854 -QRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQ 917

  Fly   679 TESILDNERQ---PA-QESRSQGKIGLGIYGKYFSA-GSGWLMVILVAFFCLGTQILASGGDYFL 738
            ||..||:..:   || ::|...|::...::..|..| |:...:..|..|.|  .|:.:....|:|
Human   918 TEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLC--QQVASFCRGYWL 980

  Fly   739 SYWVKNND-SSSSTDIYIFSGINAALVIFALLRTL----LFFSMA------MHSSTQLHNTMFQG 792
            |.|..:.. ....|...:..|      ||.||..|    ||.|||      ..:|..|...:...
Human   981 SLWADDPAVGGQQTQAALRGG------IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWD 1039

  Fly   793 VSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTI 857
            |.|:.:.||...|.|.:||||:.:...||..:|..:...:.....:..:..|:.:..|...:..:
Human  1040 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL 1104

  Fly   858 TMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIH 922
            .:||.:...::.|:.:|..|:|||:.:.|.:.||.:.|..|.:.:||...|.....:  |...:.
Human  1105 PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ--NNARVD 1167

  Fly   923 SSGYYTF--LSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGM 985
            .|...:|  |..:|.....::|.....|.:....:..:....:.|.:|..::.|:.:|.|:||.:
Human  1168 ESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVV 1232

  Fly   986 RQSAELENSMTSVERVLEYRHLEAEGEFESPD-DKKPPMNWPQEGLISAEQLSLRYNPD-PKADR 1048
            |...:||||:.||||:.:|.....|..:..|. ..:||  |||.|.|......|||.|: |.|
Human  1233 RNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPLA-- 1293

  Fly  1049 VLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISII 1112
             ::.::|.|...||:|||||||||||||.:.|.|| ...||.:.||...|..:|||.|||:||||
Human  1294 -VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISII 1357

  Fly  1113 PQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLV 1177
            ||:|:||.|:||.|||..::::||.:|.|||.|.||..|:.||..|:...|:.|.:.||||:||:
Human  1358 PQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLL 1422

  Fly  1178 CLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAG 1242
            |||||:||:.:||::|||||.|||.|:..:|:.:...|..||||.|||||.:::|..||:|:|.|
Human  1423 CLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1487

  Fly  1243 TLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            .:.|.|||.:||.|  ..:||.:..::|
Human  1488 QVAESGSPAQLLAQ--KGLFYRLAQESG 1513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	423/1313 (32%)
		ABC_membrane	92..362	CDD:294371	72/274 (26%)
		ABCC_MRP_domain1	412..611	CDD:213217	87/201 (43%)
		ABC_membrane	718..981	CDD:294371	64/275 (23%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	112/222 (50%)
ABCC6	XP_024306029.1	SunT	14..1514	CDD:331423	427/1328 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151604
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.650