Protein Alignment CG9270 and ABCC6

DIOPT Version :10

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: NP_001162.5
• Gene: ABCC6 / 368
• HGNCID: 57
• Length: 1503
• Species: Homo sapiens
• Alignment Length: 1328
• Identity: 427/1328 - (32%)
• Similarity: 691/1328 - (52%)
• Gaps: 89/1328 - (6%)

  Fly     7 QTNP-RESAGIF-STLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATW---QSEV 66
            |:|| .|:...| |...|.:...::::|.::.|.|.||::..:|:.:|.|..:....|   :|..
Human   199 QSNPCPETGAAFPSKATFWWVSGLVWRGYRRPLRPKDLWSLGRENSSEELVSRLEKEWMRNRSAA 263

  Fly    67 R-------------SCGDSPKKEP------SIIRVILKVFGWQLFLSGIVVGVLEL----GTRAT 108
            |             |...:|:.||      |..|.:||.. ||:|.|..::|.|.|    ..|.|
Human   264 RRHNKAIAFKRKGGSGMKAPETEPFLRQEGSQWRPLLKAI-WQVFHSTFLLGTLSLIISDVFRFT 327

  Fly   109 LPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYR 173
            :|.:| :|..||..:.........:..:.:.||.....|.....|..|..|.|::|.|::..:||
Human   328 VPKLL-SLFLEFIGDPKPPAWKGYLLAVLMFLSACLQTLFEQQNMYRLKVLQMRLRSAITGLVYR 391

  Fly   174 KALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGI 238
            |.|.||..:...:..|.||||:|.|:.|...::::.:.|||..:.:::...:|:|.:|.::|..|
Human   392 KVLALSSGSRKASAVGDVVNLVSVDVQRLTESVLYLNGLWLPLVWIVVCFVYLWQLLGPSALTAI 456

  Fly   239 VILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSE 303
            .:.|..||:..|:|:..:..:.:...:.|.|.|:.:.|:...:.||.:.||..|...:..:|..|
Human   457 AVFLSLLPLNFFISKKRNHHQEEQMRQKDSRARLTSSILRNSKTIKFHGWEGAFLDRVLGIRGQE 521

  Fly   304 MSSIRKVNYIRG-TLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFP 367
            :.::|....:.. :|:||:::...:|:.|..:..::....:.||:||......|||.:... |.|
Human   522 LGALRTSGLLFSVSLVSFQVSTFLVALVVFAVHTLVAENAMNAEKAFVTLTVLNILNKAQA-FLP 585

  Fly   368 SGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLEN 432
            ..:....:..|:..|:..|:...|.:...:....:... .|:..:.:.|....|:.:. .|.|..
Human   586 FSIHSLVQARVSFDRLVTFLCLEEVDPGVVDSSSSGSA-AGKDCITIHSATFAWSQES-PPCLHR 648

  Fly   433 INISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILF 497
            ||:::....|:||:||||:|||||:.|:||||....|.:.::|.::|..||.|:.|.||.:|:.|
Human   649 INLTVPQGCLLAVVGPVGAGKSSLLSALLGELSKVEGFVSIEGAVAYVPQEAWVQNTSVVENVCF 713

  Fly   498 GLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDD 561
            |..:|......|:..|||:.|.:.. .|..|.:||:|.:|||||:.|:||||||||:|..|||||
Human   714 GQELDPPWLERVLEACALQPDVDSFPEGIHTSIGEQGMNLSGGQKQRLSLARAVYRKAAVYLLDD 778

  Fly   562 PLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKS 624
            ||:|:|.|||:|:|.:.:  .|.|:....|||||.|..|..||.|:::..|.|:.:|:|:|:|
Human   779 PLAALDAHVGQHVFNQVIGPGGLLQGTTRILVTHALHILPQADWIIVLANGAIAEMGSYQELL-- 841

  Fly   625 GQDFGKL--LATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRV-SVTSV--------DSS 678
             |..|.|  |..:|::.||..:.:......:::.:.|.:.:...:.|. |:.||        ::.
Human   842 -QRKGALMCLLDQARQPGDRGEGETEPGTSTKDPRGTSAGRRPELRRERSIKSVPEKDRTTSEAQ 905

  Fly   679 TESILDNERQ---PA-QESRSQGKIGLGIYGKYFSA-GSGWLMVILVAFFCLGTQILASGGDYFL 738
            ||..||:..:   || ::|...|::...::..|..| |:...:..|..|.|  .|:.:....|:|
Human   906 TEVPLDDPDRAGWPAGKDSIQYGRVKATVHLAYLRAVGTPLCLYALFLFLC--QQVASFCRGYWL 968

  Fly   739 SYWVKNND-SSSSTDIYIFSGINAALVIFALLRTL----LFFSMA------MHSSTQLHNTMFQG 792
            |.|..:.. ....|...:..|      ||.||..|    ||.|||      ..:|..|...:...
Human   969 SLWADDPAVGGQQTQAALRGG------IFGLLGCLQAIGLFASMAAVLLGGARASRLLFQRLLWD 1027

  Fly   793 VSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTI 857
            |.|:.:.||...|.|.:||||:.:...||..:|..:...:.....:..:..|:.:..|...:..:
Human  1028 VVRSPISFFERTPIGHLLNRFSKETDTVDVDIPDKLRSLLMYAFGLLEVSLVVAVATPLATVAIL 1092

  Fly   858 TMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIH 922
            .:||.:...::.|:.:|..|:|||:.:.|.:.||.:.|..|.:.:||...|.....:  |...:.
Human  1093 PLFLLYAGFQSLYVVSSCQLRRLESASYSSVCSHMAETFQGSTVVRAFRTQAPFVAQ--NNARVD 1155

  Fly   923 SSGYYTF--LSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGM 985
            .|...:|  |..:|.....::|.....|.:....:..:....:.|.:|..::.|:.:|.|:||.:
Human  1156 ESQRISFPRLVADRWLAANVELLGNGLVFAAATCAVLSKAHLSAGLVGFSVSAALQVTQTLQWVV 1220

  Fly   986 RQSAELENSMTSVERVLEYRHLEAEGEFESPD-DKKPPMNWPQEGLISAEQLSLRYNPD-PKADR 1048
            |...:||||:.||||:.:|.....|..:..|. ..:||  |||.|.|......|||.|: |.|
Human  1221 RNWTDLENSIVSVERMQDYAWTPKEAPWRLPTCAAQPP--WPQGGQIEFRDFGLRYRPELPLA-- 1281

  Fly  1049 VLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISII 1112
             ::.::|.|...||:|||||||||||||.:.|.|| ...||.:.||...|..:|||.|||:||||
Human  1282 -VQGVSFKIHAGEKVGIVGRTGAGKSSLASGLLRLQEAAEGGIWIDGVPIAHVGLHTLRSRISII 1345

  Fly  1113 PQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLV 1177
            ||:|:||.|:||.|||..::::||.:|.|||.|.||..|:.||..|:...|:.|.:.||||:||:
Human  1346 PQDPILFPGSLRMNLDLLQEHSDEAIWAALETVQLKALVASLPGQLQYKCADRGEDLSVGQKQLL 1410

  Fly  1178 CLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAG 1242
            |||||:||:.:||::|||||.|||.|:..:|:.:...|..||||.|||||.:::|..||:|:|.|
Human  1411 CLARALLRKTQILILDEATAAVDPGTELQMQAMLGSWFAQCTVLLIAHRLRSVMDCARVLVMDKG 1475

  Fly  1243 TLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            .:.|.|||.:||.|  ..:||.:..::|
Human  1476 QVAESGSPAQLLAQ--KGLFYRLAQESG 1501

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	PLN03130	10..1289	CDD:215595	425/1325 (32%)
ABCC6	NP_001162.5	MRP_assoc_pro	14..1502	CDD:188098	427/1328 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	854..919		12/64 (19%)