Protein Alignment CG9270 and Sur

DIOPT Version :9

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: NP_001334732.1
• Gene: Sur / 34350
• FlyBaseID: FBgn0028675
• Length: 2223
• Species: Drosophila melanogaster
• Alignment Length: 2027
• Identity: 452/2027 - (22%)
• Similarity: 719/2027 - (35%)
• Gaps: 795/2027 - (39%)

  Fly    14 AGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEPS 78
            |..:|...|.:..|:|:.|.|:.||..||.....|..|.:..|.|...:..:.:....|    ||
  Fly   226 ATFYSKSCFWWLTPLLWLGYKEPLELEDLGQMKLEDSARSHYDHFLYIYTEKKKKSNSS----PS 286

  Fly    79 IIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGAL----IAEFTRN-------------GN- 125
            :....:| ..||:|..|   |:|:|.  ..|..::|.|    |.|:...             ||
  Fly   287 LWYCYIK-NSWQMFALG---GILKLA--GDLFALIGPLAIQKIVEYIEQLYAQASEPPAKSPGNE 345

  Fly   126 --------------------GDGL---------WAQIY--GLTLILSILFSVLMFHPLMMGLMHL 159
                                |..:         |:.:.  |..:...:|.:.:....|.....|:
  Fly   346 VANVLLSTSRILGTEFDEVFGTNIDKVRIYSSTWSDLLANGWCIAWIVLLAAITQGALSQASTHI 410

  Fly   160 ----AMKMRVAVSTAIYRKALRLSRTALGDT--TTGQVVNL------------------------ 194
                .::::.::...||||:|.|:.....|:  :.|||.:.
  Fly   411 LNMTGIRIKTSLQGLIYRKSLLLNADGGCDSSDSAGQVQSTSSTSDEKQKNDDSMATPEHVDNPS 475

  Fly   195 ---ISNDLGRF-------DRALIHF----HFLWLGPLELLISSYFLYQQIGVASLYG-IVILLLF 244
               ||:|:|..       .|.::.|    |:.|..|.::.:..|.||..:|::::.| |..:::.
  Fly   476 EPNISHDIGSITNHMTEDTRNIMEFFLIIHYAWAIPFKIAVVIYLLYMNLGISAVIGSIACIVIM 540

  Fly   245 LPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRK 309
            .|:|.|:....|:.....|..||:|::.:::.:.||:|||:..|::.|.:.|:..||.|:..:.|
  Fly   541 TPLQFFIGNAMSKNAEVIAGYTDERLKRIHDTLVGIKVIKLNAWDEVFLKKIQEARRKELKYLNK 605

  Fly   310 VNYIRGTLLSFEITLSRIAIFVSLLGFVLMG----------GELTAERAFSVTAFYNILRRTV-C 363
                ..|..:....|:.||  ..|:.||.:|          .:|.|.|.||..|.:..|  || .
  Fly   606 ----DATFWTLMAVLTHIA--TVLITFVTLGVYVWLHRDQEFDLNASRLFSSLALFQQL--TVPL 662

  Fly   364 KFFPSGMSQFAEMMVTLRRIKGFMMRSE------------------------------------- 391
            ..||..:.......|:.||::.|:..||
  Fly   663 LIFPITVPIIIAARVSTRRLERFLKSSEIQKQFEGIRNMARILSKSDASLDMYETQEKSNMTMRT 727

  Fly   392 -------TEALYLKGGQT-------------------------------NKLFEG---------- 408
                   .|....:..||                               |||.:.
  Fly   728 AQAENRLNEKRLAQKSQTPELATNSTPLLQNAEESAEDISPSTVQELGHNKLVQQRRELLRNTPY 792

  Fly   409 -------------EPLVKLQSFQAR----WNHDHV-----EPVLENIN--------------ISL 437
                         |..|:....:||    |..|.:     :.:..:||              :.|
  Fly   793 VAIRPPKMRGSVMERPVEFSVIRARNTDSWRRDSLLLKMPDDIAVSINDGLFTWQPQSQMPVVQL 857

  Fly   438 SPP-------QLVAVIGPVGSGKSSLIQAILGELPGESGKL--KVQGDISYASQEPWLFNASVRD 493
            ..|       :|..|:|..||||:||:.|:|.|:|..:|.:  .....|||.||:|||.|.::|:
  Fly   858 HVPGIIVPKGKLTIVVGKNGSGKTSLLSALLMEMPLLAGNMFWHKTCTISYVSQQPWLLNDTIRE 922

  Fly   494 NILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTY 557
            |||||......||..|:..|||:.|.||: .||.:.:||||.::|||||.||::|||:|..|:..
  Fly   923 NILFGESFRPKRYDFVLEACALKPDIELMPRGDLSIIGERGINISGGQRQRIAIARAIYSSANVV 987

  Fly   558 LLDDPLSAVDTHVGRHLFEECMRGFLR--DKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEE 620
            ::||||:::|..||.|:|:.|:|..|:  ::..||||.||..::.|:.::.:..|::.|.|:|.:
  Fly   988 IMDDPLASLDNEVGEHIFQHCIREMLQKSNRTFILVTQQLHRIKEAEYLIAIKDGRVEACGSYAD 1052

  Fly   621 -----------------MLKS-----GQDFGKLLATE-------AQEMG---------DSN---- 643
                             |.|:     .|:.|:..|.|       ..::|         |:|
  Fly  1053 IELMQPRITAEWNAIIAMAKAKNDNPSQNPGEKTAGERWKLLKNVSKLGLQRSISVTMDANVACH 1117

  Fly   644 ----------------------QEQVN-------------------------------------- 648
                                  .:||:
  Fly  1118 ADAIDGSGCISVANMQSNVVEEDDQVSVSYPIGNASCGGFNLQRKRSSIYGSRHLMYDVPLPIDE 1182

  Fly   649 AEGD----------------SRNDKSTY------------------------------------- 660
            .:||                |||..|::
  Fly  1183 CQGDDVIMRPRRRHTLGRRGSRNTNSSHRLSGLSTLTATSESSSISGDVLSRSVLATSCSSYAES 1247

  Fly   661 -------------------------------SRQSSRVSRVSVTSVD------------------ 676
                                           ||.:|....:.|.:.|
  Fly  1248 SVDGGDLATAAPEPRVQSWQPPQHVTHHQPLSRNASSPPAMEVANPDVKKSEEARRSNTSSESPL 1312

  Fly   677 ------------------------------SSTESILD----------------------NERQ- 688
                                          |:|.|||.                      ||.|
  Fly  1313 DDHVRGSFQQFLRRMSMRRSNKPKNHHHPLSATNSILSISEESPPVVHFPASILATDGNKNETQS 1377

  Fly   689 --------------------------------------PAQE----------------------- 692
                                                  ||.:
  Fly  1378 EEKPKKCVNIDSKETTINCDDNCYSASDKELRANVTSSPADQEQHNERHVLAEVAGESGRESMPL 1442

  Fly   693 -------SRSQGKIGLGIYGKYFSAGSGWLMVILVAFF--CLGTQILASGGDYFLSYW------- 741
                   .|..|||...||..|..|..   :.|:..||  .|..|.|....|.:|..|
  Fly  1443 ARLAIDTERKYGKISDDIYLMYIRAAG---LPIITIFFITALIWQCLRVYTDIWLQQWSNVHGRV 1504

  Fly   742 -------VKNNDSSSSTDIY--IFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTA 797
                   :..::.......|  :::.|:...:|.||:.|........::...||:.:.|.:....
  Fly  1505 ASKGHVVLHPSEQDHEVTYYFRMYAAISCVCIIMALVSTPAGQYAGCNARRNLHDKLLQTILHKT 1569

  Fly   798 LYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQI-FLTISGIIGVLCITNPWYLINTITMFL 861
            |:||...|.|||:|||:.|:..:|:.:.|.....:|. .|.:|.|:..:.|| ||.|:.|:.:..
  Fly  1570 LHFFQVTPLGRIVNRFSNDMAVIDKKIAATGQRLLQFTLLCLSAILINVTIT-PWILVLTLPICG 1633

  Fly   862 AFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGY 926
            |::.::.||..::|:|:|:|....||:.||.|.|:.|::||||...|...|:......:.::..|
  Fly  1634 AYYLIQKFYRCSARELQRIENATNSPVISHLSETIQGVTTIRAFNQQTRFTEILFKRLEANTIAY 1698

  Fly   927 YTFLSTNRAFGYYLDLF--CVAYVISVTLM----------------------------------- 954
            ....:::|..|..||..  |:.:|.:||.:
  Fly  1699 ALLNTSHRWLGVSLDYLGGCIVFVATVTALTAASVSCRRHYEATTSPSASASPSPFETYAVTKSP 1763

  Fly   955 SYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRH------------- 1006
            |...|   :|..:||.|...:.:...:.|.::..|::|....||||:..|..
  Fly  1764 SELRP---SPSLVGLAINYTLLVPIYLNWVVKLLADMEMYAGSVERIAHYAQGQDADADADADAD 1825

  Fly  1007 -------------------------------------------LEAEGE---------------- 1012
                                                       ::.:|:
  Fly  1826 ADVDADLDHEPSSNEDVSAEVDRSSQSDAGDKVYPGATTAAGDVDEDGDQQRIGGARGGGGDCGY 1890

  Fly  1013 ----------------------------FESP---------------------------DDK--- 1019
                                        |..|                           |||
  Fly  1891 RQGHENGAEANADKLNAGNVTGDGNHLNFHHPPATAGDKVEQATTKTSVIKDKQLPPQQDDKDKK 1955

  Fly  1020 -----KP----------PMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRT 1069
                 :|          |::|||.|.|..:.:||||  :.:...|:.:|...|...::|||.|||
  Fly  1956 VVLPNEPARKLERYQSVPISWPQRGDIHFDNVSLRY--EGQKQNVISNLTLKIPAGQRIGICGRT 2018

  Fly  1070 GAGKSSLINALFR-LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQY 1133
            |:|||||..:||. |....|.:.||:.||..|...:||:::|||||:..||:.|:|.||||...:
  Fly  2019 GSGKSSLGLSLFGVLQTTRGHIYIDDVDIQRIRPDELRTRLSIIPQDVHLFNATIRENLDPHGYF 2083

  Fly  1134 ADEKLWEALEEVHLKDEVS-ELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATA 1197
            .|.:||..||...||:.|: .||.||::|:.:||.|.|.|.|||:||||||||.:..||:||||:
  Fly  2084 QDLQLWNCLELAQLKEFVNGHLPLGLDTVICDGGLNLSAGHRQLLCLARAILRGSVCLVLDEATS 2148

  Fly  1198 NVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVF 1262
            .:|..|::.:.......||..|::||||||.||:|.||::|||.|.:||.|:|.| |.|....||
  Fly  2149 VLDSSTESALLKAADLAFRGRTIITIAHRLTTILDYDRLIVLDQGRIVEDGNPRE-LQQLEGSVF 2212

  Fly  1263 YGMVLQTGRSSF 1274
            .|: |:.|.|.:
  Fly  2213 RGL-LEKGASKW 2223

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	445/2008 (22%)
		ABC_membrane	92..362	CDD:294371	78/373 (21%)
		ABCC_MRP_domain1	412..611	CDD:213217	84/233 (36%)
		ABC_membrane	718..981	CDD:294371	76/318 (24%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	103/222 (46%)
Sur	NP_001334732.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	3.160