DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and CG7627

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001245943.1	Gene:	CG7627 / 34148	FlyBaseID:	FBgn0032026	Length:	1355	Species:	Drosophila melanogaster

Alignment Length:	1363	Identity:	752/1363 - (55%)
Similarity:	986/1363 - (72%)	Gaps:	90/1363 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MQAKK---LQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATW 62
            ||:.|   |..||||.....|...|.:.:|...||||:||:..|||.||||||:||||:|..|:|
  Fly     1 MQSLKTADLPENPREHCNFISAACFWYTMPTFIKGRKRTLDTKDLYRALKEHKSETLGNKLCASW 65

  Fly    63 QSEVRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGD 127
            :.|:    :..|.:|:::|.:|:||||...|.|:|:.:||||.|...|:.|..|||.:| :|:..
  Fly    66 ELEL----EKTKGKPNLLRALLRVFGWYFALLGLVLFLLELGLRTLQPIFLLKLIAYYT-HGSES 125

  Fly   128 GLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVV 192
            ...|..|...:||....:|::.||.|:|.||:.:||||.:.:.|||||||||::||||||.|.||
  Fly   126 IESAYYYAAGVILCSALNVIIMHPYMLGTMHVGLKMRVGMCSMIYRKALRLSKSALGDTTAGHVV 190

  Fly   193 NLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSR 257
            ||:|||:||.|.|.|..|:||:||||.|..:|.:|::||:|:::|:..:|||:|:|.:|.:.||.
  Fly   191 NLMSNDVGRLDLATIFVHYLWVGPLETLFITYLMYREIGIAAVFGVAFMLLFIPLQAYLGKRTSV 255

  Fly   258 LRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEI 322
            ||.:||||||:||||||||||||||||||.||.||..::...|:.|:::||.|:||||.||||.|
  Fly   256 LRLRTALRTDERVRMMNEIISGIQVIKMYAWELPFEHMVAFARKKEINAIRHVSYIRGILLSFII 320

  Fly   323 TLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFM 387
            .|:|::||:||:|:||:|..||.|.||.:||:|||||.|:..|||.|:||.||.:|:::|::.:|
  Fly   321 FLTRVSIFLSLVGYVLLGTFLTPEVAFLITAYYNILRTTMTVFFPQGISQMAETLVSIKRVQKYM 385

  Fly   388 MRSET------------------EALYLKGGQ-----TNKLFEGEPL-------------VKLQS 416
            ...||                  |.::..|.:     .:||. |.|:             :.:..
  Fly   386 QSDETNVMDMSVDLTEDFQGSNQETVHADGDEERDEAEDKLL-GPPIATVNENAKLSEAGISISG 449

  Fly   417 FQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYAS 481
            ..|:|:.:..:..|..:|:.:.|..::.::|..||||||||||||||||.|||::||.|.:||||
  Fly   450 LMAKWDVNSPDYSLNGVNLRVQPGTMLGIVGRTGSGKSSLIQAILGELPAESGEIKVNGSMSYAS 514

  Fly   482 QEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARIS 545
            ||||||:.:||.|||||.|||:.||..|::.|||||||||| ..|:|.||||||||||||:||||
  Fly   515 QEPWLFSGTVRQNILFGQPMDRRRYAKVVKKCALERDFELLPFKDKTIVGERGASLSGGQKARIS 579

  Fly   546 LARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKG 610
            |||||||:...||||||||||||||.|||||:||||:||:::|||.|||||||:|||.|||||||
  Fly   580 LARAVYRETSIYLLDDPLSAVDTHVARHLFEQCMRGYLRERIVILATHQLQFLQHADQIVIMDKG 644

  Fly   611 KISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSV 675
            ::|||||||.:.:||.||..:||...::      ||......||:...|:|....|  |.|..|:
  Fly   645 RVSAVGTYESLRESGLDFASMLADPERD------EQSEERSRSRSGSYTHSHSDQR--RNSEQSL 701

  Fly   676 DSSTESILDN---ERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYF 737
            .|..:|.:|:   |:...||.:..|:|||.:|.|||.||.|:....::..||:.:|.|||.||||
  Fly   702 LSMADSCMDDLEAEQANNQERQEAGQIGLRLYSKYFKAGGGFFAFFVMMGFCVLSQGLASLGDYF 766

  Fly   738 LSYWV----------KNNDSSSS----------------------TDIYIFSGINAALVIFALLR 770
            |||||          .|||::.|                      .|.|||:.|....::..:.|
  Fly   767 LSYWVTKKGNVAYRADNNDTTRSEELEPRLSTWLRDIGLSVDAEMLDTYIFTVITVLTILVTVAR 831

  Fly   771 TLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIF 835
            :.|||::||.:|.:|||:||:|::|.|:|||:.||||||||||:.|:|||||||||||:|.||||
  Fly   832 SFLFFNLAMKASIRLHNSMFRGITRAAMYFFNTNPSGRILNRFSKDMGQVDEILPAVMMDVIQIF 896

  Fly   836 LTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLS 900
            |.::||:.|:.:.||.:||.|:.:.:.|:.||||||.||||:||:|||.|||:|||.:|:|.|||
  Fly   897 LALAGIVIVIAVVNPLFLIPTVVLGIIFYQLRTFYLKTSRDVKRMEAITRSPVYSHLAASLTGLS 961

  Fly   901 TIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPG 965
            ||||..||.:|..|:|||||:|||.:|.|:||:|||||:||.|||.|:..:||..:..||. |.|
  Fly   962 TIRAFGAQRVLEAEFDNYQDMHSSAFYMFISTSRAFGYWLDCFCVIYIAIITLSFFIFPPA-NGG 1025

  Fly   966 QIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGL 1030
            .:||.|||||.|||.|||||||||||||:||:||||:||..:|.||..|:|.|||||.:||::|.
  Fly  1026 DVGLAITQAMGMTGMVQWGMRQSAELENTMTAVERVVEYEDIEPEGALEAPADKKPPKSWPEQGK 1090

  Fly  1031 ISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNEGSLVIDNT 1095
            |..::|||||.||||::.|||||:|:|.|:||:|||||||||||||||||||||||:||::||..
  Fly  1091 IVFDELSLRYTPDPKSENVLKSLSFVIKPKEKVGIVGRTGAGKSSLINALFRLSYNDGSVLIDKR 1155

  Fly  1096 DILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLES 1160
            |...:||||||||||||||||||||||:|.|||||::|:|:|||.:||||.||:.|::||:||:|
  Fly  1156 DTSEMGLHDLRSKISIIPQEPVLFSGTMRYNLDPFDEYSDDKLWRSLEEVKLKEVVADLPSGLQS 1220

  Fly  1161 VVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAH 1225
            .:.|||:|:|||||||||||||||||||||||||||||||||||.|||:|||.||::||||||||
  Fly  1221 KITEGGTNFSVGQRQLVCLARAILRENRILVMDEATANVDPQTDGLIQTTIRNKFKECTVLTIAH 1285

  Fly  1226 RLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLKLALEAHERR 1288
            ||:||:|||:|:|:|||..||||:|:||||.:.||||:|||.|||.:::|.|||:|.:|.|.|
  Fly  1286 RLHTIMDSDKVLVMDAGRAVEFGTPYELLTLADSKVFHGMVKQTGHATYESLLKIAQKAFENR 1348

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	731/1322 (55%)
		ABC_membrane	92..362	CDD:294371	146/269 (54%)
		ABCC_MRP_domain1	412..611	CDD:213217	130/199 (65%)
		ABC_membrane	718..981	CDD:294371	152/294 (52%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	165/220 (75%)
CG7627	NP_001245943.1	CFTR_protein	12..1315	CDD:273530	728/1317 (55%)
		ABC_membrane	107..360	CDD:294371	138/253 (55%)
		ABCC_MRP_domain1	445..645	CDD:213217	130/199 (65%)
		ABC_membrane	815..1014	CDD:294371	116/198 (59%)
		ABCC_MRP_domain2	1089..1310	CDD:213211	165/220 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440878
Domainoid	1	1.000	179	1.000	Domainoid score	I1056
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1131	1.000	Inparanoid score	I210
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm26173
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
	13	12.810