DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and CG7806

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_609207.1	Gene:	CG7806 / 34140	FlyBaseID:	FBgn0032018	Length:	1487	Species:	Drosophila melanogaster

Alignment Length:	1324	Identity:	417/1324 - (31%)
Similarity:	651/1324 - (49%)	Gaps:	143/1324 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 RESAGIFSTLMFCFALPILFK---GRKKTLEPTDLYNALKEHKAETLGDKF-FATWQSEVRSCGD 71
            ::.|.:.|..:|.:..|::.|   |:.:.:|  ||::.........|.:|. .|..||:
  Fly   227 QDEANLGSRFLFHWVQPLILKGVAGKLRKIE--DLFDLPDALNITRLSEKLHLALSQSQ------ 283

  Fly    72 SPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGL 136
                  |:.|.:.:.||.:.:|.||:..:.:|...|. ||:||.|:    |..:.|......|.|
  Fly   284 ------SLWRALHRCFGVEFYLIGILRLIADLSGFAG-PLLLGGLL----RQDHADPNQVYYYAL 337

  Fly   137 TLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALG-DTTTGQVVNLISNDLG 200
            .|..|.|.|.:........:..::|||||.|..:||||||.    |.| ..:...::||:|.|..
  Fly   338 GLFGSTLLSAVCATHFDWRMAMVSMKMRVGVVNSIYRKALE----ARGLKESKPDLLNLMSTDTD 398

  Fly   201 RFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALR 265
            |...:.|.|||.|..|.:|..:.|.||.|:|.|.|.|::...|.:||..:|::............
  Fly   399 RIVNSCISFHFFWSIPFKLFTTLYLLYLQLGAAFLAGVIFAALLIPINRWLAKRIGIFSSGLMTA 463

  Fly   266 TDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIF 330
            .|.|:....|.:.|.:.||:..||..|...|..||:.|:..:.|..|:....:.|..|   ..:.
  Fly   464 KDARLSATTETMQGAKQIKINAWEDIFITKIRGLRQEELRFLSKRKYLDAMCVYFWAT---TPVL 525

  Fly   331 VSLLGF---VLMGGELTAERAF-SVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFM--MR 389
            :.||.|   ||||..|.|...: ||...|.::  .....||..::...|..|:::|::..|  ..
  Fly   526 MCLLTFGVSVLMGNPLIASTTYTSVALLYMLI--GPLNAFPWVLNGLIEAWVSIKRVQQLMDVPN 588

  Fly   390 SETEALY---LKGGQTNKLFEGEPL-----VKLQSFQARWNHDHVEPV------LENINISLSPP 440
            .:..:.|   ::|...:...:..||     ..||...|.:.||..|..      :::||:.:...
  Fly   589 LDYSSYYNPIMRGSGGSGAGDDAPLDAPKASVLQMKCASFCHDSDEQTSPTPFRMKDINVDIKAG 653

  Fly   441 QLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQ---GDISYASQEPWLFNASVRDNILFGLPMD 502
            |||.:.||||.||||.:.||:..|....|::.||   ....|..|.|||...::||||::|...|
  Fly   654 QLVCIEGPVGGGKSSFLSAIVANLQCTDGEVCVQELTTGFGYVPQSPWLQRGTIRDNIVWGAQFD 718

  Fly   503 KHRYRNVIRNCALERDFELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVD 567
            :..|:.|:..||||.|.::|.||...|||.|.:||||||||::||||||:....|||||.||::|
  Fly   719 EQWYKTVLHACALEEDLQILGGDLVGVGENGRTLSGGQRARVALARAVYQDKKVYLLDDVLSSLD 783

  Fly   568 THVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLL 632
            .||.||:.:.|:...|:.|..|:||..:|...||:.|:               .:|.||......
  Fly   784 AHVARHIIKHCILRLLKHKTRIVVTRNIQLFFHANQIL---------------QVKDGQLLPSEY 833

  Fly   633 ATEAQEMG---DSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVD-SSTESILDNERQPAQES 693
            .|::.|:.   |::.||          :.|..|:|..:|    ...| .|.:|:|      .:|.
  Fly   834 MTQSIELSLDEDADDEQ----------EPTVRRRSVELS----NQYDKKSLDSLL------LEEL 878

  Fly   694 RSQGKIGLGIYGKYFSAGSGWL-MVILVAFFCLGTQILASGGDYFLSYWV--------KNN---- 745
            |..|.:...::..|:.|.:..| ..:|::...:  |:..:..|.:|:|||        ||:
  Fly   879 REYGHLSGNVFTCYWKAVTSPLAFTVLLSVVLM--QLTRNLSDAWLAYWVTETTLDPHKNDTSLD 941

  Fly   746 ------------DSSSSTDIY--IFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRT 796
                        :|..:|..|  ||:.|..:..:..|.|..||....:.::..:|..:.:.|...
  Fly   942 HILMRPTVGNETESGHTTKFYLSIFTAIAVSNSLVTLARAFLFAYAGIKAAIFMHEKLLKKVMFA 1006

  Fly   797 ALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLT-ISGIIGVLCIT---NPWYLINTI 857
            ...||.....|||||||:.|...||:.||.:    :.|.|. ::|::|.||::   .||..:..|
  Fly  1007 KFNFFDITSVGRILNRFSSDTNTVDDSLPFI----LNILLAQLAGLVGALCVSLYAMPWLGLVII 1067

  Fly   858 TMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIH 922
            .|...:..|:..|...|||:|||.:.|.||:|:||:.||.||:|||:|.|.....:::....:..
  Fly  1068 PMVPIYLSLQQRYRHASRDIKRLSSNAMSPLYTHFTETLQGLTTIRSMRASPRFQRDFQVKLEES 1132

  Fly   923 SSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPP-VDNPGQIGLVITQAMSMTGTVQWGMR 986
            .....|..:..:.....|.|.....|....|::..... ..|||.:||.|:.|:|:||.:...:.
  Fly  1133 IKAQLTQSAAQQWLALRLQLLGTLLVGGAGLLAAITASHTTNPGLVGLCISYALSITGQLGDLLH 1197

  Fly   987 QSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAE--QLSLRYNPDPKADRV 1049
            ..||.|..:.:|||:.:|  |:.|.|..:....:||..||.:|::|..  |||.|.:..|    .
  Fly  1198 AVAETEQELVAVERIDQY--LQLEEEQNASGSAEPPFGWPTQGVLSFREVQLSYREHLAP----A 1256

  Fly  1050 LKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLS-YNEGSLVIDNTDILGIGLHDLRSKISIIP 1113
            |:.:.|.....|:|||||||||||:|::.||.|:: ...|.:.:|..::..:.|..||.:|.:|.
  Fly  1257 LRGITFQTEAFERIGIVGRTGAGKTSVLAALLRVAPLTHGEIRLDQVNLKTLPLSVLRERIGVIT 1321

  Fly  1114 QEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVC 1178
            |||.||.||:|.||||...:.|.::|.|::.......:.:...||:..|...|:|.|.|||||:|
  Fly  1322 QEPFLFEGTVRENLDPRHGFYDSEIWHAIKNSAAATLLVQQLGGLDGKVETCGNNLSAGQRQLLC 1386

  Fly  1179 LARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGT 1243
            ||||:|:..:::.:||.|:|:|.::|..||..:|..|:.||:|.|||||..:...||::|||.|.
  Fly  1387 LARALLKNAKVVAIDEGTSNLDDESDLSIQQALRNAFKSCTLLFIAHRLRGLHAMDRIIVLDDGR 1451

  Fly  1244 LVEFGSPFELLTQSWSKVFYGMVL 1267
            :.|.|:|..|.:.| |.:||||:|
  Fly  1452 ICEEGNPQSLASDS-STIFYGMLL 1474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	410/1312 (31%)
		ABC_membrane	92..362	CDD:294371	85/274 (31%)
		ABCC_MRP_domain1	412..611	CDD:213217	86/207 (42%)
		ABC_membrane	718..981	CDD:294371	83/293 (28%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	90/223 (40%)
CG7806	NP_609207.1	MRP_assoc_pro	6..1472	CDD:188098	414/1320 (31%)
		ABC_membrane	328..560	CDD:294371	74/240 (31%)
		ABCC_MRP_domain1	621..827	CDD:213217	87/220 (40%)
		ABC_membrane	948..1192	CDD:279056	74/247 (30%)
		ABCC_MRP_domain2	1238..1458	CDD:213211	90/223 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	133	1.000	Inparanoid score	I246
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	P	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.870