DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and ABCB5

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001157413.1	Gene:	ABCB5 / 340273	HGNCID:	46	Length:	1257	Species:	Homo sapiens

Alignment Length:	1369	Identity:	299/1369 - (21%)
Similarity:	561/1369 - (40%)	Gaps:	297/1369 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KAETLGDKFFATWQSEVRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATL----- 109
            :||.:.:.:.....:|     :.||.....:..| ::|   .|..|:.:.::.||..|:|
Human     6 RAEEMQENYQRNGTAE-----EQPKLRKEAVGSI-EIF---RFADGLDITLMILGILASLVNGAC 61

  Fly   110 ----PLIL---------GALIAEFTRNG----------NGDGLWAQIYGLTLILSILFSVLMFHP 151
                ||:|         |.|:...|.|.          |.|        :|| |::.:..:....
Human    62 LPLMPLVLGEMSDNLISGCLVQTNTTNYQNCTQSQEKLNED--------MTL-LTLYYVGIGVAA 117

  Fly   152 LMMGLMHLAMKMRVAV-STAIYRKALRLSRTA----------LGDTTTGQV--VNLISNDLGRFD 203
            |:.|.:.:::.:..|. .|...||....|..|          :|:..|...  ::.||:.:|  |
Human   118 LIFGYIQISLWIITAARQTKRIRKQFFHSVLAQDIGWFDSCDIGELNTRMTDDIDKISDGIG--D 180

  Fly   204 RALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILL-----LFLPIQTFLSRLTSRLRHQTA 263
            :..:.|..:         |::.:...:|:...:.:.::.     |.:......||:...|..:..
Human   181 KIALLFQNM---------STFSIGLAVGLVKGWKLTLVTLSTSPLIMASAAACSRMVISLTSKEL 236

  Fly   264 LRTDQRVRMMNEIISGIQ-VIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRI 327
            ....:...:..|::|.|: ||.....||...|..:.|:.::...|::.       ::.:::|..:
Human   237 SAYSKAGAVAEEVLSSIRTVIAFRAQEKELQRYTQNLKDAKDFGIKRT-------IASKVSLGAV 294

  Fly   328 AIFVS-LLGFVLMGGE---LTAERAFSV----TAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIK 384
            ..|:: ..|.....|.   |..|..:::    ..|::::..:.|  ..:.:..|....:.    :
Human   295 YFFMNGTYGLAFWYGTSLILNGEPGYTIGTVLAVFFSVIHSSYC--IGAAVPHFETFAIA----R 353

  Fly   385 G-----FMMRSETEAL--YLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEP---VLENINISLSP 439
            |     |.:..:..::  :...|...:..||....|..||    |:.. .|   :|:.:|:.:..
Human   354 GAAFHIFQVIDKKPSIDNFSTAGYKPESIEGTVEFKNVSF----NYPS-RPSIKILKGLNLRIKS 413

  Fly   440 PQLVAVIGPVGSGKSSLIQAILGELPGESGKLKV-------------QGDISYASQEPWLFNASV 491
            .:.||::|..|||||:::|.:......:.|.:.|             :..|...||||.||..::
Human   414 GETVALVGLNGSGKSTVVQLLQRLYDPDDGFIMVDENDIRALNVRHYRDHIGVVSQEPVLFGTTI 478

  Fly   492 RDNILFGLPMDKHRYRNVIRNCALER--------DF--ELLHGDRTFVGERGASLSGGQRARISL 546
            .:||.:|        |:.:.:..:||        ||  |..:...|.|||:||.:||||:.||::
Human   479 SNNIKYG--------RDDVTDEEMERAAREANAYDFIMEFPNKFNTLVGEKGAQMSGGQKQRIAI 535

  Fly   547 ARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGK 611
            |||:.|.....:||:..||:|:. .:...:..:....:.:..|:|.|:|..:..|||||.:..|.
Human   536 ARALVRNPKILILDEATSALDSE-SKSAVQAALEKASKGRTTIVVAHRLSTIRSADLIVTLKDGM 599

  Fly   612 ISAVGTYEE-MLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSV 675
            ::..|.:.| |.|.|..:..:::.:.:            :.|.:.:..|||.: .:.:.:.:.||
Human   600 LAEKGAHAELMAKRGLYYSLVMSQDIK------------KADEQMESMTYSTE-RKTNSLPLHSV 651

  Fly   676 DSSTESILDNERQPAQESRSQGKIGLGIYGKYFSAGSGWLMVILV------AFFCLGTQILASGG 734
            .|.....:|.    |:||....:|.|....         |:.||.      .|..|||......|
Human   652 KSIKSDFIDK----AEESTQSKEISLPEVS---------LLKILKLNKPEWPFVVLGTLASVLNG 703

  Fly   735 ---DYFLSYWVK------NNDSSS-STDIYIFSGINAALVIFALLRTLLFFSMAMHS-------- 781
               ..|...:.|      |||.:: ..|..|:|      :||.:|..:.|.|..|..
Human   704 TVHPVFSIIFAKIITMFGNNDKTTLKHDAEIYS------MIFVILGVICFVSYFMQGLFYGRAGE 762

  Fly   782 --STQLHNTMFQGVSRTALYFF--HANPSGRILNRFAMDLGQVD-------------------EI 823
              :.:|.:..|:.:....:.:|  ..|.:|.:....|:|:.|:.                   .:
Human   763 ILTMRLRHLAFKAMLYQDIAWFDEKENSTGGLTTILAIDIAQIQGATGSRIGVLTQNATNMGLSV 827

  Fly   824 LPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPM 888
            :.:.:......||.:| |..||.:|.   :|.|..|       ..|.....::||....||...:
Human   828 IISFIYGWEMTFLILS-IAPVLAVTG---MIETAAM-------TGFANKDKQELKHAGKIATEAL 881

  Fly   889 YSHFSATLNGLSTIRAMEA--QDLLTKEYDN-----------YQDIHSSGYYTFLSTNRAFGYYL 940
            .:  ..|:..|:..:|.|.  :::|..::.|           |...|:..|:.:.:..| ||
Human   882 EN--IRTIVSLTREKAFEQMYEEMLQTQHRNTSKKAQIIGSCYAFSHAFIYFAYAAGFR-FG--- 940

  Fly   941 DLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQ----AMSMTGTVQWGMRQSAELENSMTSVERV 1001
                 ||:|....|:        |..:.:|.|.    ||::..|    :..:.|...:.:....:
Human   941 -----AYLIQAGRMT--------PEGMFIVFTAIAYGAMAIGET----LVLAPEYSKAKSGAAHL 988

  Fly  1002 LEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRY--NPDPKADRVLKSLNFIIMPREKIG 1064
            ......:...:..|.:.|||.   ..||.:...::|..|  .||.   .:|:.|:..|...:.:.
Human   989 FALLEKKPNIDSRSQEGKKPD---TCEGNLEFREVSFFYPCRPDV---FILRGLSLSIERGKTVA 1047

  Fly  1065 IVGRTGAGKSSLINALFRLSYN--EGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNL 1127
            .||.:|.|||:.:..|.|| |:  :|.::.|..|...:.:..|||:|:|:|||||||:    |::
Human  1048 FVGSSGCGKSTSVQLLQRL-YDPVQGQVLFDGVDAKELNVQWLRSQIAIVPQEPVLFN----CSI 1107

  Fly  1128 DPFEQYAD-------EKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILR 1185
            .....|.|       :::.||....::...:..||....:.|...|:..|.||:|.:.:|||:|:
Human  1108 AENIAYGDNSRVVPLDEIKEAANAANIHSFIEGLPEKYNTQVGLKGAQLSGGQKQRLAIARALLQ 1172

  Fly  1186 ENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSP 1250
            :.:||::||||:.:|..::.::|..:.:.....|.|.:.|||:.|.::|.::||..|.:.|.|:.
Human  1173 KPKILLLDEATSALDNDSEKVVQHALDKARTGRTCLVVTHRLSAIQNADLIVVLHNGKIKEQGTH 1237

  Fly  1251 FELL 1254
            .|||
Human  1238 QELL 1241

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	299/1369 (22%)
		ABC_membrane	92..362	CDD:294371	56/324 (17%)
		ABCC_MRP_domain1	412..611	CDD:213217	64/224 (29%)
		ABC_membrane	718..981	CDD:294371	65/326 (20%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	70/231 (30%)
ABCB5	NP_001157413.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24		3/22 (14%)
		PTZ00265	8..1251	CDD:240339	298/1367 (22%)
		ABC_membrane	52..333	CDD:279056	52/307 (17%)
		ABC_MTABC3_MDL1_MDL2	386..623	CDD:213216	70/250 (28%)
		ABC_membrane	696..962	CDD:279056	58/301 (19%)
		ABC_MTABC3_MDL1_MDL2	1016..1254	CDD:213216	72/234 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.000