DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and wu:fb13g09

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_009289330.1	Gene:	wu:fb13g09 / 336563	ZFINID:	ZDB-GENE-030131-8507	Length:	1393	Species:	Danio rerio

Alignment Length:	1371	Identity:	455/1371 - (33%)
Similarity:	708/1371 - (51%)	Gaps:	160/1371 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGIFSTLMFCFALPILFKGRKKT-LEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDS 72
            :|.::||.||.:...:..|:.::..|.: |:..|::.......:||...:....|..|::..|
Zfish    60 HPVDNAGFFSFMTLQWLSPLAWRAHKDSCLKMEDVWGLSCHEASETNCQRLEWLWHEELKRRG-- 122

  Fly    73 PKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATL------PLILGALIAEFTRNGNGDGLWA 131
             |...|:.||.     |:...:.::|.:..|  ..|:      |.:|...:.||::...    ..
Zfish   123 -KDGASLSRVF-----WRFCQTRMLVAIFSL--LITMVAGFVGPALLIRALLEFSQCSE----VK 175

  Fly   132 QIYGLTLILSILFSVLMFHPLMMGLM-----HLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQV 191
            .:|||.|:..| |.:.:.....:..|     ..|.::|.|..|..::|.|||..|.  |.::|::
Zfish   176 LLYGLALVAGI-FLMELTRSWSLAFMWAINYRTAARLRGAALTFAFQKILRLRSTK--DVSSGEL 237

  Fly   192 VNLISNDLGRFDRALIHFHFLWLGP----LELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLS 252
            ||:.::|..|...|:.....|..||    |.|..::|||    |..:|.|..|.::|.|.....|
Zfish   238 VNICASDGQRLYEAVSVGCLLAGGPLVGMLGLTYTTYFL----GPTALVGSAIFIIFYPTMMLAS 298

  Fly   253 RLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTL 317
            |:|:..|.:....||:|||:||||:..::.||||.||.||...|:::|..|..::.....::...
Zfish   299 RMTAYFRKKCVAVTDRRVRLMNEILGCMKFIKMYCWETPFANNIQKVRSEERRNLEWAGCVQSLT 363

  Fly   318 LSFEITLSRIAIFVSLLGFVL---MGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVT 379
            |.   ....:.:..|:..|.|   :|.:|||.:||:|.|.:|.:...: |..|..:...:|..|.
Zfish   364 LG---VAPVVVVIASVCTFTLHMALGYDLTAAQAFTVVAVFNSMTFAL-KVTPLAVRALSEGSVA 424

  Fly   380 LRRIKGFMMRSETEALYLK---------------------GGQTNK------------------- 404
            ::|.:...|..:.|.:.:|                     |.||.|
Zfish   425 VKRFQKLFMMEDRELISVKTEDPYNVVEFKDATLAWEKTCGSQTKKSRTQLKRGGMKRVLRREKL 489

  Fly   405 ---LFEGEPLVKLQSFQARWNHDHVE-------------------PVLENINISLSPPQLVAVIG 447
               :...|...|::...|.....|:|                   ..|..|::.:....||.|.|
Zfish   490 SLYIITEENKGKIEEPNAEHLLTHMEQESPQSTISSTQSIRPPLHKTLHRIDLCIQKGSLVGVCG 554

  Fly   448 PVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRN 512
            .||||||||:.|:||::....|.:.|.|..:|.:|:.|:.|.|:|:|||||...::.:|..|:..
Zfish   555 GVGSGKSSLLSALLGQMTLLGGSVSVNGGFAYVAQQAWILNDSLRENILFGKKYNEEKYNAVLEA 619

  Fly   513 CALERD-FELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFE 576
            |.|..| .||.:||.|.:|||||:||||||.|:|||||:|.:....||||||||||..||..||.
Zfish   620 CCLFPDIIELPYGDMTEIGERGANLSGGQRQRVSLARALYSERPILLLDDPLSAVDARVGSRLFH 684

  Fly   577 ECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGD 641
            ..:|...:.|.||.||||||:|...|.:|:|..|:|:..||:.::::.|:|:..|..:..||
Zfish   685 SAIRPAAKGKTVIFVTHQLQYLPECDDVVLMKDGQIAEHGTHTQLMEKGRDYAALFNSVQQE--- 746

  Fly   642 SNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDS-STESILDNERQPAQESRSQGKIGLGIYG 705
             |..:.|.:...:.:|.: |.|:..||.......:| .|:.::.      .|.:..|.:...:|.
Zfish   747 -NLVRKNLKNKEKAEKES-SPQTLHVSNPPKPDTESKKTDQLMQ------AEEKGSGAVAWPVYA 803

  Fly   706 KYFSAGSG---WLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSS----------------- 750
            .|..|..|   :::.||:..|..|:   .:..:::||||::....:||
Zfish   804 AYIKAAGGPLAFIVTILLFLFTTGS---IAFSNWWLSYWIRQGSGNSSLLLGNETAESDSMRLNP 865

  Fly   751 -----TDIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRIL 810
                 :.:|:.| :.|||.: ..:|.|:|....:.:::.||:.:|:.:..:.:.||...|.||||
Zfish   866 HIQYYSRVYVLS-MGAALFL-KTIRGLVFVKCTVRAASVLHDKLFKTLLLSPMRFFDTTPLGRIL 928

  Fly   811 NRFAMDLGQVDEIL---PAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLS 872
            |||:.|:.:||..|   ..::|..:.:.|...|::|.:.   ||:|.:.|.:......:......
Zfish   929 NRFSKDMDEVDVRLAMQAEMLLQNVTLVLFCLGVVGAVF---PWFLFSIIPLGAFLFIVNRISRV 990

  Fly   873 TSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFG 937
            ..|:|||||.|::||..||.:::|.|||||.|..........|....|.:.:..:.|....|...
Zfish   991 LIRELKRLENISQSPFTSHITSSLQGLSTIYAYGRGADFIHRYQALLDTNQACQFLFSCAMRWLA 1055

  Fly   938 YYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVL 1002
            ..|||..::.:.:|.|:........:|...||.::.|:.:||..|:.:|..:|.|...|||||:.
Zfish  1056 VRLDLISISLITTVALLIVLMHGHISPAYAGLALSYAVQLTGLFQFTVRLLSETEARFTSVERIN 1120

  Fly  1003 EY-RHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIV 1066
            .| ::||:||..:.........:||.||.|:.:.:.:||...  ...|||:|.|.|:|.|.||||
Zfish  1121 HYIKNLESEGPRQITGCPTSSSSWPAEGQITFQDVEMRYRDG--LPLVLKNLCFSILPEETIGIV 1183

  Fly  1067 GRTGAGKSSLINALFRLS-YNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPF 1130
            ||||:|||||..|||||: .:.||::||..:|..|||.|||||:|:||||||||.||:|.||||:
Zfish  1184 GRTGSGKSSLGVALFRLAELSRGSIIIDGVNIAHIGLEDLRSKLSVIPQEPVLFIGTVRSNLDPW 1248

  Fly  1131 EQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEA 1195
            :||.|.::|||||:.|:||.||:|||.|.|.|.:.|.|:|||:|||:|:|||:||.::||::|||
Zfish  1249 DQYTDAQIWEALEKTHIKDMVSQLPNSLHSEVTDNGENFSVGERQLLCVARALLRHSKILLLDEA 1313

  Fly  1196 TANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSK 1260
            ||.:|.:||.|||.|||..|..||.|.|||||||::..:|:||||.|.::||.:|..|||...|:
Zfish  1314 TAAIDTETDRLIQDTIRSSFSGCTTLVIAHRLNTVLGCNRIMVLDQGQILEFDTPSNLLTDENSR 1378

  Fly  1261 VFYGMV 1266
             |:.|:
Zfish  1379 -FHAMM 1383

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	452/1360 (33%)
		ABC_membrane	92..362	CDD:294371	81/287 (28%)
		ABCC_MRP_domain1	412..611	CDD:213217	91/218 (42%)
		ABC_membrane	718..981	CDD:294371	76/287 (26%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	127/221 (57%)
wu:fb13g09	XP_009289330.1	SunT	61..1386	CDD:331423	455/1370 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585992
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.760