DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG9270 and abcc5

DIOPT Version :9

Sequence 1:NP_995741.2 Gene:CG9270 / 35366 FlyBaseID:FBgn0032908 Length:1292 Species:Drosophila melanogaster
Sequence 2:NP_001182542.1 Gene:abcc5 / 336147 ZFINID:ZDB-GENE-050517-17 Length:1426 Species:Danio rerio


Alignment Length:1349 Identity:448/1349 - (33%)
Similarity:703/1349 - (52%) Gaps:129/1349 - (9%)


- Green bases have known domain annotations that are detailed below.


  Fly     9 NPRESAGIFSTLMFCFALPILFKGRKK-TLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDS 72
            :|.::||:||.:.|.:...:.....|| .|...|::...:....|....:....|:.|:||.|: 
Zfish    94 HPVDNAGLFSFMTFNWLTSLAVLAHKKGQLFLEDIWAVSQFESCEINRRRLAGLWEEEIRSRGN- 157

  Fly    73 PKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLT 137
               :.|:.||:......:|.||.:.:.|.:|...::...::..|: |:|:....|    ..|||.
Zfish   158 ---DASLRRVVWHFCRTRLLLSILCLMVTQLAGFSSPAFVVWRLL-EYTQRSEPD----LPYGLL 214

  Fly   138 LILSILFSVLM---FHPLMMGLMH-LAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISND 198
            |:|.:|.:.|:   .|.|...|.: ...::|.|:.|..:.|.|||  .:|.:.:.|:::|:.|.|
Zfish   215 LVLGLLATELIRSWSHALTWALNYRTGTRLRGAILTMAFHKILRL--RSLREKSMGELINMCSGD 277

  Fly   199 LGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTA 263
            ..|...|......|..|||..::...:....:|..||.|..:.:||.|...|.||||:..|.:..
Zfish   278 GQRMFEAAAVGSLLAGGPLVAVLGMAYNLFVLGPTSLLGSAVFILFYPTMMFSSRLTAYFRRKGV 342

  Fly   264 LRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIA 328
            ..|||||:.||||::.|:.||||.|.|.|.:.:.|:|..|...:.:..|.:...:.....:..||
Zfish   343 AVTDQRVQKMNEILNYIKFIKMYAWVKAFSQAVRRIRDEERQILERTGYFQSITVGVAPIVVVIA 407

  Fly   329 IFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETE 393
            ...:....:|:|.:|||.:||:|...:|.:...: |..|..:...:|..|.:.|.|..::.:|.:
Zfish   408 SVATFSTHMLLGYDLTAAQAFTVVTVFNAMTFAL-KVTPFSVKSLSEASVAIDRFKSLLLMAEVK 471

  Fly   394 -----------ALYLKG------------------------------------------------ 399
                       |:.:.|                                                
Zfish   472 MIRELPRNPSVAVEMSGASLAWETGGHSAQPSPRGTPHVGTRGCRKKRRQRDVPKHHAILEEETH 536

  Fly   400 GQTNKLFEGE----PLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAI 460
            ||......||    |  |.|:.........::..|..|::|:...:||.|.|.|||||:|||.||
Zfish   537 GQLLNDVSGEMASSP--KDQTLHVPTISQRLQRTLHCIDLSIQKGKLVGVCGSVGSGKTSLISAI 599

  Fly   461 LGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HG 524
            ||::....|.:.|.||.:|.:|:.|:.|||.|||||||..|::.||:.::..|.|..|..:| .|
Zfish   600 LGQMTLLEGTVAVDGDFAYVAQQAWILNASFRDNILFGKEMEEERYQAILSACCLRPDLAMLPSG 664

  Fly   525 DRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVI 589
            |.|.:|||||:||||||.|||||||:|.....|:|||||||:|.|||.|:|...::..||.|.||
Zfish   665 DLTEIGERGANLSGGQRQRISLARALYSNRGIYILDDPLSALDAHVGNHIFNNAIKKQLRGKTVI 729

  Fly   590 LVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSR 654
            .||||||:|...|.:::|..|.|:..|::|:::....|:..:.  ...::|::...:|    .::
Zfish   730 FVTHQLQYLVDCDDVIVMRDGSIAEQGSHEDLMNVNGDYAAMF--NNLQLGETPIIEV----PNK 788

  Fly   655 NDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQESRSQGKIGLGIYGKYFSAGSGW-LMVI 718
            ...|:..:...:....||....|:|:.  |.:....:| |.:|.:...:|..|..|..|| :.:.
Zfish   789 KSGSSLKKPLEKSKAGSVKKEKSTTQG--DGQLMQVEE-RGKGSVPWAVYKVYIQALGGWPVFLF 850

  Fly   719 LVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTDI--------------------YIFSGINAAL 763
            ::|.|.|.....|. .:::|.||:|....:::..:                    .:::.....:
Zfish   851 ILALFILNVGSTAF-SNWWLCYWIKQGSGNTTVQVGNSSVLSESMRDNPLMQHYAAVYTMSMGVM 914

  Fly   764 VIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVM 828
            ::..|||.::|....:.:|::||:.:||.:.|:.:.||...|:.||||||:.|:.:||..||...
Zfish   915 LLLKLLRGIVFVKGTLRASSRLHDELFQKILRSPMKFFDTTPTARILNRFSKDMDEVDTRLPFQA 979

  Fly   829 LDCIQIFLTISGIIGVLCITNPWYLINT---ITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYS 890
            ....|..:.:...:.|:....||:|:..   :.:|...|.:...::   |:||||:.:.:||..|
Zfish   980 EMFTQNVILVLFCLAVIGSVFPWFLVAVGPLVLLFTVLHVVSRVFI---RELKRLDNVTQSPFLS 1041

  Fly   891 HFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMS 955
            |.::::.||:|:.|...:|.....|....|.:.:.:|.|....|.....||:..||.:....||.
Zfish  1042 HIASSIQGLTTVHAYGKEDEFLHRYQELLDQNQAPFYLFSCAMRWLAVRLDVISVALISITALMI 1106

  Fly   956 YFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEY---RHLEAEGEFESPD 1017
            ........|...||.|:.|:.:||..|:.:|.::|.|...|||||:..|   ..|||....:   
Zfish  1107 VLMHGQIPPAYAGLAISYAVQLTGLFQFTVRLASETEARFTSVERIHHYIKSLSLEAPARVK--- 1168

  Fly  1018 DKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR 1082
            :|.||.:|||||.|..:|..::|..:  ...:||..:|.:.|:||||||||||:|||||...|:|
Zfish  1169 NKAPPSDWPQEGEIVFDQTEMKYRDN--LPLILKKASFTVRPKEKIGIVGRTGSGKSSLGVVLYR 1231

  Fly  1083 L-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVH 1146
            | ....||:.||..:|..|||.|:|||:|||||||||||||:|.|||||.||::.::|:|||..|
Zfish  1232 LVEPCGGSIKIDGVNICDIGLADVRSKLSIIPQEPVLFSGTVRSNLDPFSQYSEAQIWDALERTH 1296

  Fly  1147 LKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTI 1211
            :|:.||:||..|||.|.|.|.|:|||:|||:|:||.:||:.:||::|||||.:..:||.|||.||
Zfish  1297 MKECVSQLPLKLESEVVENGENFSVGERQLLCVARVLLRQCKILILDEATAAMGTETDCLIQETI 1361

  Fly  1212 RRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSK 1260
            |..|:|||.||||||::|::..||:|||:.|.:|||..|.:||....|:
Zfish  1362 RNAFQDCTTLTIAHRVHTVLSCDRIMVLNQGQVVEFDEPSKLLANENSR 1410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9270NP_995741.2 CFTR_protein 6..1257 CDD:273530 447/1344 (33%)
ABC_membrane 92..362 CDD:294371 81/273 (30%)
ABCC_MRP_domain1 412..611 CDD:213217 95/199 (48%)
ABC_membrane 718..981 CDD:294371 71/285 (25%)
ABCC_MRP_domain2 1029..1250 CDD:213211 122/221 (55%)
abcc5NP_001182542.1 intraplasmic N-terminal 1..59
transmembrane domain 1 59..149 11/54 (20%)
CFTR_protein 95..1419 CDD:273530 448/1348 (33%)
ABC_membrane 177..441 CDD:294371 79/270 (29%)
nucleotide binding domain 1 188..248 15/64 (23%)
transmembrane domain 2 279..379 37/99 (37%)
nucleotide binding domain 2 403..450 13/47 (28%)
ABCC_MRP_domain1 552..751 CDD:213217 95/198 (48%)
ABC_membrane 851..1132 CDD:294371 71/284 (25%)
ABCC_MRP_domain2 1180..1400 CDD:213211 122/221 (55%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C170585982
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG51855
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100026
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
76.660

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