DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and abcc3

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_009304645.1	Gene:	abcc3 / 323301	ZFINID:	ZDB-GENE-050517-16	Length:	1540	Species:	Danio rerio

Alignment Length:	1365	Identity:	480/1365 - (35%)
Similarity:	739/1365 - (54%)	Gaps:	134/1365 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQ----------- 63
            |..:||..|.:.|.:...:..||.|..||..||::..|...:|.:.......|:
Zfish   204 PETTAGFLSRMTFWWFTRMAIKGYKSPLENKDLWSLNKNDSSELVVPGLLNQWEVEKSKAHSSDD 268

  Fly    64 ---------------SEVRSCGDSPK-------------KEPSIIRVILKVFGWQLFLSGIVVGV 100
                           :|.....:||:             ::||.:..:|:.|| ..||.|....:
Zfish   269 QNVKEQVTFTKPGSGAESNHVNESPEEAEVLLSKQQQKSRQPSFLWALLRAFG-PYFLIGSAFKL 332

  Fly   101 LELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRV 165
            |:.......|.:|..||| ||:..:....|.......:..:.|...|:.|..........|::|.
Zfish   333 LQDLITFINPQLLRMLIA-FTKQSDVPSWWGYALAFLMFGTSLLQTLILHQHFQYCFVTGMRLRT 396

  Fly   166 AVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQI 230
            .:..|||||||.::..|...:|.|:||||:|.|..||.......:.||..||::.::.:||:|.:
Zfish   397 GIIGAIYRKALVITNEAKRSSTVGEVVNLMSVDAQRFMDLTTFLNMLWSAPLQIFLALFFLWQNL 461

  Fly   231 GVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRL 295
            |.:.|.|:.:::|.:|...|::..|...:.:.....|.|:::||||::||:|:|:|.||..|...
Zfish   462 GPSVLAGVAVMVLLIPFNAFIAMKTRTYQVEQMKYKDDRIKLMNEILNGIKVLKLYAWEPSFRDK 526

  Fly   296 IERLRRSEMSSIRKVNYIRG------TLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAF 354
            |.::|:.|:..:||..|:..      |...|.:.|:..|:||:    |.....|.||:||...:.
Zfish   527 ILQIRQKELHVLRKTAYLSALSTMAWTSAPFLVALTSFAVFVN----VDEKNVLDAEKAFVSLSL 587

  Fly   355 YNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSE--TEALYLKGGQTNKLFEGEPLVKLQSF 417
            :||||..: ...|..:|...:..|:|:|::.|:...|  .|::..|...|      |..|.:.:.
Zfish   588 FNILRFPL-NMLPQVISSIVQASVSLKRLQDFLNHDELDPESVDRKSNTT------EYAVSVVNG 645

  Fly   418 QARW-NHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYAS 481
            :..| ..|.|  :|:|||:.:....|:||:|.||.||:|||.|:|||:....|::.::|.::|..
Zfish   646 KFSWAKRDQV--ILDNINVLVPQGSLLAVVGHVGCGKTSLISALLGEMEKLDGQISIRGSVAYVP 708

  Fly   482 QEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARIS 545
            |:.|:.||::|||||||.|..:.:||.|:..|||..|.|:| .||.|.:||:|.:||||||.|:|
Zfish   709 QQAWIQNATLRDNILFGRPYVEQKYRCVLEACALTPDLEVLPGGDLTEIGEKGINLSGGQRQRVS 773

  Fly   546 LARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMD 608
            ||||:|.:||.|||||||||||.||.:|:|:..:  .|.|:.|..|||||.:.||...:.|:::.
Zfish   774 LARALYSEADVYLLDDPLSAVDAHVAKHIFDHVIGPEGALKGKTRILVTHGISFLPQVNNILVLV 838

  Fly   609 KGKISAVGTYEEMLKSGQDFGKLLAT-------EAQEMG---DSNQEQVNAEGDSRN----DKST 659
            .|::|.:|:|:::|:....|.:.|..       |..|:.   |..:|:...:..|.:    |...
Zfish   839 DGRVSEMGSYQDLLRQNGAFAEFLRNYSLEDIIEDDELTVSFDEEEEEFPEDALSNHTDMVDNEP 903

  Fly   660 YSRQSSR--VSRVSVTSVDSSTESILDNERQPAQ---------------------ESRSQGKIGL 701
            ...::.|  :.::|:.|.|......:...|:.::                     |:...|::.|
Zfish   904 VVNEARRQFMRQMSIMSNDVENPKKMSRRRRCSERKHPETPTEKKEPKVEKLIQAETTETGRVKL 968

  Fly   702 GIYGKYFSAGSGWLMVILVAFFCLGTQILAS-GGDYFLSYWVKNNDS---------SSSTDIYIF 756
            .:|.:|..| .|.|:.:.:.|. .|.|..|: |.:::||.|  .||:         .:...:|..
Zfish   969 QVYWEYVKA-IGPLLALFICFL-YGCQSAAAIGANFWLSEW--TNDALHNRTQEMLQTRVGVYAA 1029

  Fly   757 SGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVD 821
            .||:..::|.::......:| .:.::...|..|...|.|....||.|.||||:||||:.|:..:|
Zfish  1030 LGISQGVLILSICLLCRAYS-TLRAARHTHQHMLNSVLRAPQAFFEATPSGRVLNRFSKDVDTID 1093

  Fly   822 EILPAVMLDCIQIFL-----TISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLE 881
            .::|    |.|.|::     |:: ::.|..:..|.:||..:.:.|.:.:::.||::|||.|||||
Zfish  1094 SLIP----DNIDIWMRTFWYTVN-VLMVCSVLTPIFLIVIVPLMLFYWWVQRFYVATSRQLKRLE 1153

  Fly   882 AIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVA 946
            :::|||:|||||.::.|.|.|||...........||..|.:...||..:.:||..|..::.....
Zfish  1154 SVSRSPIYSHFSESITGTSVIRAYGRNAAFVLMSDNKVDENQKSYYPGIVSNRWLGVRIEFIGNC 1218

  Fly   947 YVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEG 1011
            .|:...|.:.......:||.:||.::.|:.:|.::.|.:|.:::||:::.:||||.||...:.|.
Zfish  1219 IVLFAALFAVTGKDKLSPGLVGLSVSYALQVTMSLNWMVRMTSDLESNIVAVERVKEYSETQTEA 1283

  Fly  1012 EFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSL 1076
            .:|.. :||||.:||..|.:.....|:||...  .|.|||:::..:...|||||||||||||||:
Zfish  1284 PWEVL-EKKPPPDWPPLGNVEFVDYSVRYREG--LDLVLKNISLKVRGGEKIGIVGRTGAGKSSM 1345

  Fly  1077 INALFR-LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWE 1140
            ...||| |....|.:|||:..|..|||||||||::||||||||||||||.||||||:|:||::|:
Zfish  1346 TLCLFRLLEAAAGEIVIDDVKISEIGLHDLRSKLTIIPQEPVLFSGTLRMNLDPFERYSDEEVWK 1410

  Fly  1141 ALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDA 1205
            |||..||:..|:.....||...:|||.|.|||||||||||||:||:.||||:|||||.||.:||.
Zfish  1411 ALELSHLQKFVTNQAAKLELECSEGGENLSVGQRQLVCLARALLRKTRILVLDEATAAVDLETDD 1475

  Fly  1206 LIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            |||||||.:|:||||.|||||||||:|..||:|||.|.:.||.:|..|:.|  ..:|:||....|
Zfish  1476 LIQSTIRTEFQDCTVFTIAHRLNTIMDYTRVLVLDKGQIAEFDTPTNLMNQ--KGLFFGMAKDAG 1538

Fly 1271 1270
Zfish 1539 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	475/1350 (35%)
		ABC_membrane	92..362	CDD:294371	85/275 (31%)
		ABCC_MRP_domain1	412..611	CDD:213217	94/202 (47%)
		ABC_membrane	718..981	CDD:294371	81/277 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	135/221 (61%)
abcc3	XP_009304645.1	MRP_assoc_pro	10..1539	CDD:188098	480/1365 (35%)
		ABC_membrane	330..595	CDD:279056	82/269 (30%)
		ABCC_MRP_domain1	640..841	CDD:213217	94/202 (47%)
		ABC_membrane	985..1253	CDD:279056	81/276 (29%)
		ABCC_MRP_domain2	1300..1520	CDD:213211	135/221 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.760