DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc10

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001101671.1	Gene:	Abcc10 / 316231	RGDID:	1306696	Length:	1494	Species:	Rattus norvegicus

Alignment Length:	1342	Identity:	442/1342 - (32%)
Similarity:	696/1342 - (51%)	Gaps:	156/1342 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STLMFCFALPILFKG-RKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEPSIIR 81
            |...:.:..|:|.:| |.:..:|.|.....:......|...|.|.|           |:...:.|
  Rat   223 SRFSYAWLAPLLARGVRGELRQPQDTCRLPRRLHPAYLARAFQAHW-----------KEGAQLWR 276

  Fly    82 VILKVFGWQLFLSGIVVGVLEL-GTRATL--PLILGALIAEFTRNGNGDGLWAQIYGLTLILSIL 143
            .:...||    ...|.:|:|:: ||....  ||:|..|:. |...|........:|.|.|....:
  Rat   277 ALYGAFG----CCYIALGLLKMVGTMLGFSGPLLLSLLVG-FLEEGQEPLSHGLLYVLGLASGSV 336

  Fly   144 FSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIH 208
            .|.::.:.....:..:.::.||||.:.:|||.|:|..:.   ..||:|:||:..|..|.......
  Rat   337 ISAVLQNQYGYEVRKVTLQARVAVLSILYRKTLKLGPSR---PPTGEVLNLLGTDSERLLNFAGS 398

  Fly   209 FHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPI-QTFLSRLTSR----LRHQTALRTDQ 268
            ||..|..||:|.|:.|.||:|:|||.|.|:|:.||.:|: :...:|:.:.    |||:     |.
  Rat   399 FHEAWGLPLQLAITLYLLYEQVGVAFLAGLVLALLLVPVNKVIATRIMANNQEMLRHK-----DA 458

  Fly   269 RVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFVSL 333
            ||::|.|::|||:|:|.:.||:..|..::..|..|:..:|.:.|:....:.....|..:...|..
  Rat   459 RVKLMTELLSGIRVLKFFRWEQALGDRVKACRTQELGRLRVIKYLDAACVYLWAALPVVICIVIF 523

  Fly   334 LGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGF--MMRSETEALY 396
            :.:||:|.:|||.:.|:..|..::|...: ..||..::...|..|:|.||:.|  :.....||.|
  Rat   524 ITYVLLGHQLTATKVFTALALVHMLILPL-NNFPWVINGLLESKVSLDRIQRFLDLPSYSPEAYY 587

  Fly   397 LKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENI--NISLSPPQLVAVIGPVGSGKSSLIQA 459
            .....|      ||...|:..:|.::.|......:..  ::.:....||.::|.||.|||||:.|
  Rat   588 SPDPPT------EPSTVLELHEALFSWDPTGTSQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAA 646

  Fly   460 ILGELPGESGKLKVQGDIS----YASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFE 520
            |.|||....|.:.| .|:|    .|:||||:..|::|||:|||...|...||.|:..|||..|..
  Rat   647 ITGELHRLCGWVAV-SDLSKGFGLATQEPWIQCATIRDNVLFGKTFDAQLYREVLEACALNDDLS 710

  Fly   521 LL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLR 584
            :| .||:|.|||:|.:|||||||||:||||||::...|||||||:|||..|..||...|:.|.|.
  Rat   711 ILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKTLYLLDDPLAAVDADVANHLLHRCILGVLG 775

  Fly   585 DKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNA 649
            ....:|.||:.::||.|||:::|:.|::...|...|:|...|.....||         ::|||..
  Rat   776 HTTRLLCTHRTEYLERADLVLLMEAGRLVRAGPPSEILPLVQAAPTALA---------DKEQVTD 831

  Fly   650 EGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILD-----NERQPAQESRSQGKIGLGIYGKYFS 709
            .|.|                .||.:::.:||. ||     :.|...:||:|:|.:.|.:|..|:.
  Rat   832 SGQS----------------PSVHNLEKTTEE-LDVAQNTSGRLVQEESKSEGAVALHVYRAYWR 879

  Fly   710 A-GSGWLMVILVAFFCLGTQILASGGDYFLSYWV------KNND--------------------- 746
            | |||....||::...:  |...:|.|::|::|:      :|:.
  Rat   880 AMGSGLATAILISLLLM--QATRNGADWWLAHWLSQLKAGRNSSEERPASSSPRSMGFFSPRLLL 942

  Fly   747 --------------SSSSTDIYIF-------SGINAALVIFALLRTLLFFSMAMHSSTQLHNTMF 790
                          |:.|:|::.:       :|:|:   :..|||.:||.:.|:.::..||:.:.
  Rat   943 FSPGNLYIPLHKATSNGSSDVHFYLTVYATIAGVNS---LCTLLRAVLFAAGALQAAASLHHRLL 1004

  Fly   791 QGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTIS-GIIGVLCITN---PW 851
            ..:....:.|:.:.||||:||||:.|:..||:.||.:    :.|.|..| |::|:|.:..   ||
  Rat  1005 HRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFL----LNILLANSVGLLGLLAVLGSGLPW 1065

  Fly   852 YLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYD 916
            .|:....:...::.::..|.::.|:|:||.::..||:|||.:.||.||..:||..|.....:|..
  Rat  1066 LLLLLPPLSFIYYGVQRRYRASFRELRRLGSLTLSPLYSHLADTLAGLPVLRAAGATYRFEEENQ 1130

  Fly   917 NYQDIHSSGYYTFLSTNRAFGYYLDLF---CVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMT 978
            ...:::....:...:|.:.....|.|.   .|:.:..:.|:.: ...:.|||.:|||::.|:|:|
  Rat  1131 RLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQH-QQGLANPGLVGLVLSYALSLT 1194

  Fly   979 GTVQWGMRQSAELENSMTSVERVLEYR-HLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNP 1042
            |.:...:....:.|..|.||||:.||. .:..|...:.|......::|..:|.:..:.:.|.|.|
  Rat  1195 GLLSGLVSSFTQTEAMMVSVERLEEYSCDIPQEPHGQPPQSPHQRVSWLTQGSVEFQDVVLVYRP 1259

  Fly  1043 D-PKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR-LSYNEGSLVIDNTDILGIGLHDL 1105
            . |.|   |..:.|.:.|.||:|||||||:|||||...||| |..:.|.:::|..|...:.|.:|
  Rat  1260 GLPNA---LDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPSAGQVLLDGVDTSQLELAEL 1321

  Fly  1106 RSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYS 1170
            ||::::|||||.|||||:|.||||...:.|..||:|||:.|| .||:....||:..:.|.|.:.|
  Rat  1322 RSQLAVIPQEPFLFSGTVRENLDPQGLHEDRALWQALEQCHL-SEVAMAIGGLDGELGERGRDLS 1385

  Fly  1171 VGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDR 1235
            :|||||:|||||:|.:.:||.:|||||:||.:||.|:|.||.|:|.:.||||||||||||::|||
  Rat  1386 LGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICRRFANKTVLTIAHRLNTILNSDR 1450

  Fly  1236 VMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHL 1277
            |:||.||.:||..||..|..|..|  .:..:||:.:.....|
  Rat  1451 VLVLQAGRVVELDSPSALRNQPHS--LFRQLLQSSQQGAHSL 1490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	437/1320 (33%)
		ABC_membrane	92..362	CDD:294371	83/277 (30%)
		ABCC_MRP_domain1	412..611	CDD:213217	90/205 (44%)
		ABC_membrane	718..981	CDD:294371	77/317 (24%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	114/222 (51%)
Abcc10	NP_001101671.1	CFTR_protein	211..1485	CDD:273530	441/1335 (33%)
		ABC_membrane	290..552	CDD:294371	82/270 (30%)
		ABCC_MRP_domain1	599..802	CDD:213217	90/203 (44%)
		ABC_membrane	957..1190	CDD:294371	65/240 (27%)
		PBP2_NikA_DppA_OppA_like	<1201..>1274	CDD:294989	19/75 (25%)
		ABCC_MRP_domain2	1246..1465	CDD:213211	114/222 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345116
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650