DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc12

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_008770597.1	Gene:	Abcc12 / 291923	RGDID:	735100	Length:	1378	Species:	Rattus norvegicus

Alignment Length:	1372	Identity:	427/1372 - (31%)
Similarity:	704/1372 - (51%)	Gaps:	157/1372 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSC 69
            :|..||.:.||:.|...|.:..|::.:..|.||....|........::....:....|..|:...
  Rat    40 RLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTLTVDTLPPLSPYDSSDVNAKRLQILWDEEIERV 104

  Fly    70 GDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIY 134
            |  |:: .|:.||:.| |.....|..:|..:|.:...|..|.:|...|.:...|.:...:...|.
  Rat   105 G--PER-ASLGRVVWK-FQRTRVLMDVVANILCIIMAALGPTVLIHQILQHVTNISSGHIGISIC 165

  Fly   135 GLTLILSILFSVLMFHPLMMGLMH-LAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISND 198
            ....:.:..|:.::|..|...:.: .|::::||:||.|::..  ||...|...:.|:|:|::|:|
  Rat   166 LCLALFATEFTKVLFWALAWAINYRTAIRLKVALSTLIFKNL--LSFKTLTHISAGEVLNVLSSD 228

  Fly   199 -LGRFDRALIHFHFLWLG---PLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLR 259
             ...|:.||    |..|.   |:.:::.:.:.:..:|..:|.||.:.|:|:|||.|:::|.|..|
  Rat   229 SYSLFEAAL----FCPLPATIPILMVVCAVYAFFILGSTALVGICVYLIFIPIQMFMAKLNSAFR 289

  Fly   260 HQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITL 324
            ......||:||:.|||.::.|::||||.|||.|...|..:|:.|...:.|..|::....:....:
  Rat   290 RSAISVTDKRVQTMNEFLTCIKLIKMYAWEKSFMNTIHDIRKREKKLLEKAGYVQSGNSALAPIV 354

  Fly   325 SRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIK----- 384
            |.|||..:....:.:...|||..||||.|.:|:::.::. ..|..:...||..|:|||:|
  Rat   355 STIAIVSTFTCHIFLKRTLTAPVAFSVIAMFNVMKFSIA-ILPFSVKAVAEASVSLRRMKKILVA 418

  Fly   385 ----GFMMRSETEALYLKGGQTNKLFEGE------PL--------------VKLQSFQARWNHDH 425
                .::.:.|.....|........:|.|      ||              .:|.|.|:..:...
  Rat   419 KSPPSYITQPEDPDTILLLANATLTWEQEINRKRGPLKTQDQRRHVFKKQRAELYSEQSLSDQGV 483

  Fly   426 VEP---------VLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYAS 481
            ..|         ||.||:..:...:::.:.|.|||||||||.|:||::..:.|.:.|.|.::|.|
  Rat   484 ASPERQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVSGPLAYVS 548

  Fly   482 QEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRT-------FVGERGASLSG 538
            |:.|:|:.:||:|||||...:..||::.:..|.|::|...| :||.|       .:||||.:|||
  Rat   549 QQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTECHYPHLQIGERGVNLSG 613

  Fly   539 GQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADL 603
            |||.|||||||||.....|||||||||||.|||:|:||||::..|:.|.|:||||||||||..|.
  Rat   614 GQRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVVLVTHQLQFLESCDE 678

  Fly   604 IVIMDKGKISAVGTYEEMLKSGQDFGKLL--------------------ATEAQEMGDSNQEQVN 648
            :::::.|:|...||::|:::....:.||:                    .|..:.....:::.|.
  Rat   679 VILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAMVETLKESQAQRDEDAVL 743

  Fly   649 AEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQ----ESRSQGKIGLGIYGKYFS 709
            |.||.|::                 ..:..||..:|.:....|    ||..:|.:....|..|..
  Rat   744 ASGDERDE-----------------GKEPETEEFVDIKAPVHQLIQIESPQEGIVTWKTYHTYIK 791

  Fly   710 AGSGWLMVILVAFFCLGTQILASGGDYFLSYWV--------------KNNDSSSSTD-------- 752
            |..|:|:..||  .||  ..|..|...|.::|:              ::|:::.:.:
  Rat   792 ASGGYLVSFLV--LCL--FFLMMGSSAFSTWWLGLWLDSGSQVICAPQSNETACNVNQTLQDTKH 852

  Fly   753 -----IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNR 812
                 :||.|.:  :::.|.:::...|.:..:.:|:.|||.:|..:..:.:.||...|:||::||
  Rat   853 HMYQLVYIASMM--SVLTFGIIKGFTFTNTTLMASSSLHNRVFNKIVSSPMSFFDTTPTGRLMNR 915

  Fly   813 FAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDL 877
            |:.|:.::|..||....:.:|.|..:..|:.::..:.|..|:....:.:.|..|...:....::|
  Rat   916 FSKDMDELDVRLPFHAENFLQQFSMVVFILVIMAASFPVVLVVLAGLAILFFILLRIFHRGVQEL 980

  Fly   878 KRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDL 942
            |::|.|:|||.:||.::::.||..|.|.:.:|....::....|.:||....|....|.|...:|:
  Rat   981 KQVENISRSPWFSHITSSMQGLGVIHAYDKKDDCISKFKALNDENSSHLLYFNCALRWFALRMDI 1045

  Fly   943 ------FCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERV 1001
                  |.||.:::::..|.      :....||.::..:.::|.:|..:|...|.:...||.|.:
  Rat  1046 LMNIVTFVVALLVTLSFSSI------SASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELM 1104

  Fly  1002 LEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIV 1066
            .||.........:|......|.:||..|.|:.:...:||..:  ...||..||..|...:.:|||
  Rat  1105 REYISTCVPEHTQSFKVGTCPKDWPSRGEITFKDYRMRYRDN--TPLVLDGLNLNIQSGQTVGIV 1167

  Fly  1067 GRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPF 1130
            ||||:|||||..||||| ....|::.||..||..:||.:||:|:::|||:||||.||:|.||||.
  Rat  1168 GRTGSGKSSLGMALFRLVEPASGTIFIDEVDICTVGLEELRTKLTMIPQDPVLFVGTVRYNLDPL 1232

  Fly  1131 EQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEA 1195
            ..:.||.||..||...::|.:.:||..|::.|.|.|.|:|||:|||:|:|||:||.::|:::|||
  Rat  1233 GSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKIILLDEA 1297

  Fly  1196 TANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAG-----TLVEFGSPFELLT 1255
            ||::|.:||.|:||||:..|:.||||||||||||:::.|.|:|::.|     .::||..| |:|.
  Rat  1298 TASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVQEVLVIEFDKP-EVLA 1361

  Fly  1256 QSWSKVF 1262
            :.....|
  Rat  1362 EKPDSAF 1368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	426/1364 (31%)
		ABC_membrane	92..362	CDD:294371	79/274 (29%)
		ABCC_MRP_domain1	412..611	CDD:213217	97/215 (45%)
		ABC_membrane	718..981	CDD:294371	66/295 (22%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	109/226 (48%)
Abcc12	XP_008770597.1	CFTR_protein	44..1348	CDD:273530	420/1345 (31%)
		ABC_membrane	127..388	CDD:294371	78/266 (29%)
		ABCC_MRP_domain1	487..686	CDD:213217	93/198 (47%)
		ABC_membrane	802..1084	CDD:294371	65/293 (22%)
		ABCC_MRP_domain2	1132..1357	CDD:213211	109/226 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345076
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660