DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc6

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_006541009.1	Gene:	Abcc6 / 27421	MGIID:	1351634	Length:	1500	Species:	Mus musculus

Alignment Length:	1232	Identity:	367/1232 - (29%)
Similarity:	599/1232 - (48%)	Gaps:	104/1232 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 AKKLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVR 67
            ::.|...|...|...|..||.:|..:|::|.||.|.|.||::..:|:.:|.|..:....|:   |
Mouse   271 SQPLNPCPEAEASFPSKAMFWWASGLLWRGYKKLLGPKDLWSLGRENSSEELVSQLEREWR---R 332

  Fly    68 SCGDSP---------------------KKEPSIIRVILKVFGWQLFLSGIVVGVLEL----GTRA 107
            ||...|                     .:...::|.|     |::|.|..::|.|.|    ..|.
Mouse   333 SCNGLPGHKGHSSVGAPETEAFLQPERSQRGPLLRAI-----WRVFRSTFLLGTLSLVISDAFRF 392

  Fly   108 TLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIY 172
            .:|.:| :|..||..:.|.......:..:.:..:.....|.....|.....|.|::|.|::..:|
Mouse   393 AVPKLL-SLFLEFMGDRNSSAWTGWLLAVLMFAAACLQTLFEQQHMYRAKVLQMRLRTAITGLVY 456

  Fly   173 RKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYG 237
            ||.|.||..:...:..|.||||:|.|:.|...::|:.:.|||..|.:.:...:|:|.:|.::|..
Mouse   457 RKVLVLSSGSRKSSAAGDVVNLVSVDIQRLAESIIYLNGLWLLFLWIFVCFVYLWQLLGPSALTA 521

  Fly   238 IVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRS 302
            :.:.|..||:..|:::.....:.:...:...|.|:.:.::..::.||.:.||..|...:..:|..
Mouse   522 VAVFLSLLPLNFFITKKRGFHQEEQMRQKASRARLTSSMLRTVRTIKSHGWEHAFLERLLHIRGQ 586

  Fly   303 EMSSIRKVNYIRG-TLLSFEITLSRIAIFV-SLLGFVLMGGELTAERAFSVTAFYNILRRTVCKF 365
            |:|:::....:.. :|:||:::...:|:.| ::...|.....:.||:||......:||.:... |
Mouse   587 ELSALKTSTLLFSVSLVSFQVSTFLVALVVFAVHTLVAEDNAMDAEKAFVTLTVLSILNKAQA-F 650

  Fly   366 FPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQ--TNKLFEGEPLVKLQSFQARWNHDHVEP 428
            .|..:....:..|:..|:..|:...|.:    ..|.  :|.....:..:.:.:....|:.:. .|
Mouse   651 LPFSVHCIVQARVSFDRLAAFLCLEEVD----PNGMIASNSRRSSKDRISVHNGTFAWSQES-PP 710

  Fly   429 VLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRD 493
            .|..||:::....|:||:||||:|||||:.|:||||....|.:.::|.::|..||.|:.|.||.:
Mouse   711 CLHGINLTVPQGCLLAVVGPVGAGKSSLLSALLGELLKVEGSVSIEGSVAYVPQEAWVQNTSVVE 775

  Fly   494 NILFGLPMDKHRYRNVIRNCALERDF-ELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTY 557
            |:.|...:|....:.|:..|||..|. ....|..|.:||:|.:|||||:.|:|||||||::|..|
Mouse   776 NVCFRQELDLPWLQKVLDACALGSDVASFPAGVHTPIGEQGMNLSGGQKQRLSLARAVYKKAAIY 840

  Fly   558 LLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEE 620
            ||||||:|:|.||.:.:|::.:  .|.|:....|||||.|..|..||.|:::..|.|:.:|:|::
Mouse   841 LLDDPLAALDAHVSQQVFKQVIGPSGLLQGTTRILVTHTLHVLPQADRILVLANGTIAEMGSYQD 905

  Fly   621 MLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSV---------D 676
            :|:.......||....|..|..:.    |..|.........|.:.|..|...|..         :
Mouse   906 LLQRNGALVGLLDGARQPAGTHDA----ATSDDLGGFPGGGRPTCRPDRPRPTEAAPVKGRSTSE 966

  Fly   677 SSTESILDNERQPA----QESRSQGKIGLGIYGKYFSA-GSGWLMVILVAFFCLGTQILASGGDY 736
            ...|:.||:.....    ::|...|::...||..|..| |:......|..|.|  .|:.:....|
Mouse   967 VQMEASLDDPEATGLTAEEDSVRYGRVKTTIYLSYLRAVGTPLCTYTLFLFLC--QQVASFSQGY 1029

  Fly   737 FLSYWVKNNDSSSSTDIYIFSG--INAAL--VIFALLRTL----LFFSMA------MHSSTQLHN 787
            :||.|         .|..:..|  ::|||  .:|.||..|    ||.|||      ..:|..|..
Mouse  1030 WLSLW---------ADDPVVDGRQMHAALRGWVFGLLGCLQAIGLFASMAAVFLGGARASGLLFR 1085

  Fly   788 TMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTIS-GIIGV-LCIT-- 848
            ::...|:|:.:.||...|.|.:||||:.:...||..:|    |.::..||.: |::.| |.:|
Mouse  1086 SLLWDVARSPIGFFERTPVGNLLNRFSKETDTVDVDIP----DKLRSLLTYAFGLLEVGLAVTMA 1146

  Fly   849 NPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTK 913
            .|..::..:.:.:.:...::.|::||..|:|||:...|.:.||.:.|..|...:||..||...|.
Mouse  1147 TPLAIVAILPLMVLYAGFQSLYVATSCQLRRLESARYSSVCSHMAETFQGSLVVRAFRAQASFTA 1211

  Fly   914 EYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMT 978
            ::|...|.:....:..|..:|.....|:|.....|......:..:....:.|.:|..::.|:.:|
Mouse  1212 QHDALMDENQRVSFPKLVADRWLATNLELLGNGLVFVAATCAVLSKAHLSAGLVGFSVSAALQVT 1276

  Fly   979 GTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPD 1043
            .|:||.:|...:|||||.:||||.:|..:..|..:..|.....|: ||..|.|......||:.|:
Mouse  1277 QTLQWVVRSWTDLENSMVAVERVQDYARIPKEAPWRLPTCAAQPL-WPCGGQIEFRDFGLRHRPE 1340

  Fly  1044 -PKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLR 1106
             |.|   ::.::..|...||:|||||||||||||...|.|| ...||::.||...|..:|||.||
Mouse  1341 LPLA---VQGVSLKIHAGEKVGIVGRTGAGKSSLAWGLLRLQEAAEGNIWIDGVPITHVGLHTLR 1402

  Fly  1107 SKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSN 1168
            |:|:||||:||||.|:||.|||..:::.||.:|.|||.|.||..|:.||..|:...|..|.:
Mouse  1403 SRITIIPQDPVLFPGSLRMNLDLLQEHTDEGIWAALETVQLKAFVTSLPGQLQYECAGQGDD 1464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	367/1229 (30%)
		ABC_membrane	92..362	CDD:294371	67/275 (24%)
		ABCC_MRP_domain1	412..611	CDD:213217	82/201 (41%)
		ABC_membrane	718..981	CDD:294371	73/280 (26%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	67/142 (47%)
Abcc6	XP_006541009.1	MRP_assoc_pro	101..1465	CDD:188098	367/1232 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650