DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc5

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_038818.2	Gene:	Abcc5 / 27416	MGIID:	1351644	Length:	1436	Species:	Mus musculus

Alignment Length:	1396	Identity:	462/1396 - (33%)
Similarity:	703/1396 - (50%)	Gaps:	209/1396 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 NPRESAGIFSTLMFCFALPILFKGRKK-TLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDS 72
            :|.::||:||.:.|.:..|:.....|| .|...|::...|...::....:....||.|:...|..
Mouse    99 HPVDNAGLFSYMTFSWLSPLARVVHKKGELLMEDVWPLSKYESSDVNSRRLERLWQEELNEVGPD 163

  Fly    73 PKKEPSIIRVILKVFGWQLFLSGIVVGVLELG---------------TRAT-------LPLILGA 115
               ..|:.||:......:|.||.:.:.:.:|.               |:||       |.|:||.
Mouse   164 ---AASLRRVVWIFCRTRLILSIVCLMITQLAGFSGPAFVVKHLLEYTQATESNLQYSLLLVLGL 225

  Fly   116 LIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSR 180
            |:.|..|:.:....||..|                       ...:::|.|:.|..::|.|:|..
Mouse   226 LLTEVVRSWSLALTWALNY-----------------------RTGVRLRGAILTMAFKKILKLKN 267

  Fly   181 TALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFL 245
              :.:.:.|:::|:.|||..|...|......|..||:..::...:....:|.....|..:.:||.
Mouse   268 --IKEKSLGELINICSNDGQRMFEAAAVGSLLAGGPVVAILGMIYNVIILGPTGFLGSAVFILFY 330

  Fly   246 PIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKV 310
            |...|:||||:..|.:....||.||:.|||:::.|:.||||.|.|.|.:.::::|..|...:.|.
Mouse   331 PAMMFVSRLTAYFRRKCVAATDDRVQKMNEVLTYIKFIKMYAWVKAFSQCVQKIREEERRILEKA 395

  Fly   311 NYIRGTLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAE 375
            .|.:...:.....:..||..|:....:.:|..|||.:||:|...:|.:...: |..|..:...:|
Mouse   396 GYFQSITVGVAPIVVVIASVVTFSVHMTLGFHLTAAQAFTVVTVFNSMTFAL-KVTPFSVKSLSE 459

  Fly   376 MMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQA--RWNHDH------------- 425
            ..|.:.|.|...:..|...:      .||  ...|.:|::...|  .|:..|
Mouse   460 ASVAVDRFKSLFLMEEVHMI------KNK--PASPHIKIEMKNATLAWDSSHSSIQNSPKLTPKM 516

  Fly   426 ---------------------------------------------------------VEPVLENI 433
                                                                     ::..|.||
Mouse   517 KKDKRATRGKKEKSRQLQHTEHQAVLAEQKGHLLLDSDERPSPEEEEGKQIHTGSLRLQRTLYNI 581

  Fly   434 NISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFG 498
            ::.:...:||.:.|.|||||:||:.||||::....|.:.|.|..:|.:|:.|:.||::|||||||
Mouse   582 DLEIEEGKLVGICGSVGSGKTSLVSAILGQMTLLEGSIAVSGTFAYVAQQAWILNATLRDNILFG 646

  Fly   499 LPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDP 562
            ...|:.||.:|:.:|.|..|..:| :.|.|.:|||||:||||||.|||||||:|.....|:||||
Mouse   647 KEFDEERYNSVLNSCCLRPDLAILPNSDLTEIGERGANLSGGQRQRISLARALYSDRSIYILDDP 711

  Fly   563 LSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQD 627
            |||:|.|||.|:|...:|..|:.|.|:.||||||:|...|.::.|.:|.|:..||:||::....|
Mouse   712 LSALDAHVGNHIFNSAIRKRLKSKTVLFVTHQLQYLVDCDEVIFMKEGCITERGTHEELMNLNGD 776

  Fly   628 ----FGKLLATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQ 688
                |..||      :|::...::|::      |.....|.|:.......|| ...:::...|.|
Mouse   777 YATIFNNLL------LGETPPVEINSK------KEATGSQKSQDKGPKPGSV-KKEKAVKSEEGQ 828

  Fly   689 PAQ-ESRSQGKIGLGIYGKYFSAGSGWL--MVILVAFFC-LGTQILASGGDYFLSYWVKNNDSSS 749
            ..| |.:.||.:...:|..|..|..|.|  :||:|.|.. :|:...::   ::||||:|....:|
Mouse   829 LVQVEEKGQGSVPWSVYWVYIQAAGGPLAFLVIMVLFMLNVGSTAFST---WWLSYWIKQGSGNS 890

  Fly   750 S----------------------TDIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQG 792
            :                      ..||..|  .|.::|...:|.::|....:.:|::||:.:|:.
Mouse   891 TVYQGNRSFVSDSMKDNPFMQYYASIYALS--MAVMLILKAIRGVVFVKGTLRASSRLHDELFRR 953

  Fly   793 VSRTALYFFHANPSGRILNRFAMDLGQVDEILP--AVML--DCIQIFLTISGIIGVLCITNPWYL 853
            :.|:.:.||...|:|||||||:.|:.:||..||  |.|.  :.|.:|..:..|.||.    ||:|
Mouse   954 ILRSPMKFFDTTPTGRILNRFSKDMDEVDVRLPFQAEMFIQNVILVFFCVGMIAGVF----PWFL 1014

  Fly   854 INTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNY 918
            :....:.:.|..|........|:||||:.|.:||..||.::::.||:||.|...:......|...
Mouse  1015 VAVGPLLILFSLLHIVSRVLIRELKRLDNITQSPFLSHITSSIQGLATIHAYNKRQEFLHRYQEL 1079

  Fly   919 QDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPGQI-----GLVITQAMSMT 978
            .|.:.:.::.|....|.....|||..:|.:.:..||.     |...|||     ||.|:.|:.:|
Mouse  1080 LDDNQAPFFLFTCAMRWLAVRLDLISIALITTTGLMI-----VLMHGQIPSAYAGLAISYAVQLT 1139

  Fly   979 GTVQWGMRQSAELENSMTSVERVLEY---RHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRY 1040
            |..|:.:|.::|.|...|||||:..|   ..|||....:   :|.||.:|||||.::.|...:||
Mouse  1140 GLFQFTVRLASETEARFTSVERINHYIKTLSLEAPARIK---NKAPPHDWPQEGEVTFENAEMRY 1201

  Fly  1041 NPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHD 1104
            ..:  ...|||.::|.|.|:||||||||||:|||||..||||| ..:.|.:.||...|..|||.|
Mouse  1202 REN--LPLVLKKVSFTIKPKEKIGIVGRTGSGKSSLGMALFRLVELSGGCIKIDGIRISDIGLAD 1264

  Fly  1105 LRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNY 1169
            ||||::||||||||||||:|.|||||.||.::::|:|||..|:|:.:::||..|||.|.|.|.|:
Mouse  1265 LRSKLAIIPQEPVLFSGTVRSNLDPFNQYTEDQIWDALERTHMKECIAQLPLKLESEVMENGDNF 1329

  Fly  1170 SVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSD 1234
            |||:|||:|:|||:||..:||::|||||.:|.:||.|||.|||..|.|||:|||||||:|::.||
Mouse  1330 SVGERQLLCIARALLRHCKILILDEATAAMDTETDLLIQETIREAFADCTMLTIAHRLHTVLGSD 1394

  Fly  1235 RVMVLDAGTLVEFGSPFELLTQSWSKVFYGM 1265
            |:|||..|.:|||.:|..||:...|: ||.|
Mouse  1395 RIMVLAQGQVVEFDTPSVLLSNDSSR-FYAM 1424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	458/1386 (33%)
		ABC_membrane	92..362	CDD:294371	73/291 (25%)
		ABCC_MRP_domain1	412..611	CDD:213217	92/271 (34%)
		ABC_membrane	718..981	CDD:294371	84/294 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	127/221 (57%)
Abcc5	NP_038818.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41
		PLN03130	100..1424	CDD:215595	461/1393 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	501..569		1/67 (1%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	798..822		5/24 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841660
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660