DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc8

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_037171.2	Gene:	Abcc8 / 25559	RGDID:	3786	Length:	1582	Species:	Rattus norvegicus

Alignment Length:	1451	Identity:	430/1451 - (29%)
Similarity:	697/1451 - (48%)	Gaps:	237/1451 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 FSTLMFCFA--LPIL-------------------FKGRKKTLEPTDL-----------YNALKE- 48
            ||.|.||..  |.||                   ||..::...|.||           .|.|.:
  Rat   164 FSQLRFCLTGLLVILYGMLLLVEVNVIRVRRYVFFKTPREVKPPEDLQDLGVRFLQPFVNLLSKG 228

  Fly    49 ------------HK----------------AETLGDKFFATWQSEVRSCGDSPKKEPSIIRVILK 85
                        ||                |.|...:....:.::.|....|.:...:|.|.:..
  Rat   229 TYWWMNAFIKTAHKKPIDLRAIGKLPIAMRALTNYQRLCLAFDAQARKDTQSQQGARAIWRALCH 293

  Fly    86 VFGWQLFLSG---IVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILS------ 141
            .||.:|.||.   |:..:|....    ||.:..::....:..:......|..|:..:.|
  Rat   294 AFGRRLVLSSTFRILADLLGFAG----PLCIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGN 354

  Fly   142 -ILFSVLMFHPLMMGLMHL----------AMKMRVAVSTAIYRKALRLSRT--ALGDTTTGQVVN 193
             .:.:||:|..|::....|          .:.:|.|:.|.||.|.:.||.:  ::|:.|.||:.|
  Rat   355 AYVLAVLLFLALLLQRTFLQASYYVAIETGINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICN 419

  Fly   194 LISNDLGRFDRALIHFHF----LWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRL 254
            |::.|..:    |:.|.|    ||..|:::::....||..:||::|.|..:::|..|:|.|::..
  Rat   420 LVAIDTNQ----LMWFFFLCPNLWAMPVQIIVGVILLYYILGVSALIGAAVIILLAPVQYFVATK 480

  Fly   255 TSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLS 319
            .|:.:..|...:::|::..||::.||:::|:|.||..|...:|:.||.||:|:|.........:.
  Rat   481 LSQAQRSTLEYSNERLKQTNEMLRGIKLLKLYAWENIFCSRVEKTRRKEMTSLRAFAVYTSISIF 545

  Fly   320 FEITLSRIAIFVSLLGFV--LMGGELTAERAFSVTAFYNILRRTVCKFF--PSGMSQFAEMMVTL 380
            ....:...|:.::.:|.|  ....:.:...||:..:.::||   |...|  .|.:....:.:|::
  Rat   546 MNTAIPIAAVLITFVGHVSFFKESDFSPSVAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSV 607

  Fly   381 RRIKGFMMRSET-------------------EALYLKGGQTNKLFEGE------PLVKL------ 414
            :::..|:..:|.                   :|:.||.....:....|      ||.:|
  Rat   608 QKLSEFLSSAEIREEQCAPREPAPQGQAGKYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSTDG 672

  Fly   415 --QSFQAR-------WNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGK 470
              .:|..:       |..|.: |.|.||.|.:...||..::|.||.|||||:.|.|||:...||.
  Rat   673 DADNFCVQIIGGFFTWTPDGI-PTLSNITIRIPRGQLTMIVGQVGCGKSSLLLATLGEMQKVSGA 736

  Fly   471 L---------------------------KVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRN 508
            :                           :.:|.::||||:|||.||:|.:||.|..|.:|.||:.
  Rat   737 VFWNSSLPDSEGEDPSNPERETAADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKM 801

  Fly   509 VIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGR 572
            ||..|:|:.|.::| |||:|.:||||.:||||||.|||:|||:|:..:...||||.||:|.|:..
  Rat   802 VIEACSLQPDIDILPHGDQTQIGERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSD 866

  Fly   573 HLFEECMRGFLRD--KLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSG----QDFGKL 631
            ||.:..:...|||  :.|:||||:||:|.|||.|:.|..|.|...||.::..:|.    :.:..|
  Rat   867 HLMQAGILELLRDDKRTVVLVTHKLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTL 931

  Fly   632 LATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESIL---DNERQPAQES 693
            :..:.||:                :|.|...:.:......:....||.:.:|   |.|.:.|.||
  Rat   932 MNRQDQEL----------------EKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAES 980

  Fly   694 ----------RSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKN---- 744
                      ..:.||......||.|: :|.|::.|:.|..|...::....||:|:.|..:
  Rat   981 EEDDNLSSVLHQRAKIPWRACTKYLSS-AGILLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVL 1044

  Fly   745 ----NDSSSSTDIYIFSGINAALVIFALLRTLLFFSMAMHSST----------QLHNTMFQGVSR 795
                .:.|.|.:..:...:.|  ::|.:|.:|......:.|.|          :||.::...:..
  Rat  1045 SPAARNCSLSQECALDQSVYA--MVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIIL 1107

  Fly   796 TALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCI--QIFLTISGIIGVLCITNPWYLINTIT 858
            ..:.||...|.|.|||||:.|...:|:.:|:. |:|:  ...|.:|. :.|:....|.:|:..:.
  Rat  1108 APMRFFETTPLGSILNRFSSDCNTIDQHIPST-LECLSRSTLLCVSA-LAVISYVTPVFLVALLP 1170

  Fly   859 MFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHS 923
            :.:..:|::.::...||||::|:...:.|:.|||:.|:.||:||||...:....::...|.|.::
  Rat  1171 LAVVCYFIQKYFRVASRDLQQLDDTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNN 1235

  Fly   924 SGYYTFLSTNRAFGYYLDLF--CVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMR 986
            .......:.||.....::..  ||..:.:.|.:|.......:.|.:||.:|.|:.::..:.|.:|
  Rat  1236 IASLFLTAANRWLEVRMEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVR 1300

  Fly   987 QSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLK 1051
            ..|::|..:.:|:|:......|||...........|.|||.:|.|..:.||:||  |.....|||
  Rat  1301 NLADMEIQLGAVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLK 1363

  Fly  1052 SLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQE 1115
            .:|.:|.|.:||||.||||:||||...|.||: ...||.::||..||..:.||.|||::|||.|:
  Rat  1364 HVNALISPGQKIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQD 1428

  Fly  1116 PVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLA 1180
            |||||||:|.||||.::.:|..||||||...||..|..||.||::::.|||.|:|.|||||.|||
  Rat  1429 PVLFSGTIRFNLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLA 1493

  Fly  1181 RAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLV 1245
            ||.:|:..|.:||||||::|..|:.::|..:...|.|.||:|||||::||:.:|.||||..|.::
  Rat  1494 RAFVRKTSIFIMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAIL 1558

  Fly  1246 EFGSPFELLTQSWSKVFYGMV 1266
            ||..|.:||:|. ..||...|
  Rat  1559 EFDKPEKLLSQK-DSVFASFV 1578

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	426/1440 (30%)
		ABC_membrane	92..362	CDD:294371	71/297 (24%)
		ABCC_MRP_domain1	412..611	CDD:213217	96/243 (40%)
		ABC_membrane	718..981	CDD:294371	66/284 (23%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	114/221 (52%)
Abcc8	NP_037171.2	CFTR_protein	223..1582	CDD:273530	417/1392 (30%)
		ABC_membrane	<375..590	CDD:279056	58/221 (26%)
		P-loop_NTPase	679..907	CDD:304359	94/228 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	741..768		0/26 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	939..962		2/38 (5%)
		ABC_membrane	1017..1295	CDD:279056	65/281 (23%)
		ABCC_SUR2	1343..1582	CDD:213255	121/239 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345064
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740