DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and abc4

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_594558.1	Gene:	abc4 / 2543059	PomBaseID:	SPAC30.04c	Length:	1469	Species:	Schizosaccharomyces pombe

Alignment Length:	1320	Identity:	387/1320 - (29%)
Similarity:	629/1320 - (47%)	Gaps:	205/1320 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 MFCFAL------PILFKGRKKTLEPTDL-----YNALKEHKAETLGDKFFATWQSEVRSCGDSPK 74
            ||.||.      |::...:::.:|..|.     |:   ::||.|.  :|             ...
pombe   233 MFNFACSYGYLNPLVLTAKRRVVEVDDTPVIPDYD---KNKAWTY--RF-------------ERM 279

  Fly    75 KEPSIIRVILKVFGWQLFL----SGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYG 135
            |.||:...|.|:| |:..|    |..:|.|.:..:...|..:|..|.:..:.:.|      .:..
pombe   280 KTPSLFITIHKIF-WRQILGMGVSSFMVSVCQFLSPIALNRLLKHLESPSSSSVN------PLVW 337

  Fly   136 LTLILSILFSVLMFHP--LMMGLMHLAMKMRVAVSTAIYRKAL--RLSRTALGDTTTGQVVNLIS 196
            :.|:|:..|...:|..  |.|...:||......|. .||.|.:  |..:...||:..|:..||||
pombe   338 IVLLLTGPFLTSLFTQFYLFMSTRYLARSYTTLVQ-QIYNKVIRSRFVQNKSGDSKVGRSNNLIS 401

  Fly   197 NDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQ 261
            .|:..........|.:...|:|:..|.|.|.:.:|.::..|:.:.:|...:...|..|.::|..:
pombe   402 TDVDDIGEIREFIHIIVRAPVEIAGSIYLLQKLLGWSAYVGLALTVLTCSVPIVLGPLVAKLTLR 466

  Fly   262 TALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSR 326
            ....||.|:.:|:|::..|::.|.:.||.|....:::.|:.|::...|:..:.   :..::.:..
pombe   467 ANRATDSRIELMSELLQSIRITKFFGWELPMLDRVKQRRQVELNRTWKLLLME---ICIQVLVES 528

  Fly   327 IAIFVSLLGFV----LMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFM 387
            :.:|.....||    :||..:|...||:..:.::.: ||...:....|.|..::.|::.|:..|:
pombe   529 LPVFSMFATFVVFTTIMGQTITPSIAFTSISLFSFI-RTQFSWIAYLMRQIVQIFVSIGRVSDFL 592

  Fly   388 MRSETEALYLKGGQTNKLFEGEPLVKLQS-------FQA--RW--NHDHVEPVLENINISLSPPQ 441
                           |...|.:|:..::.       |.|  .|  |....:..|.::||.....:
pombe   593 ---------------NDPDEVDPVNTIEDTSQEIGFFNASLTWVSNPSPGDFCLRDLNIVFPRNK 642

  Fly   442 LVAVIGPVGSGKSSLIQAILGELPGESG--KLKVQGDISYASQEPWLFNASVRDNILFGLPMDKH 504
            |..||||.||||||||.|:||||....|  .|.....:||.||.|||.||::||||||..|..:.
pombe   643 LSIVIGPTGSGKSSLISALLGELSLNKGSYNLPRSKGVSYVSQVPWLRNATIRDNILFDYPYIEE 707

  Fly   505 RYRNVIRNCALERDFE-LLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDT 568
            ||:.||:.|.|..|.: .:..|.|.:||:|.:|||||:.||:||||||......|:||..||:|.
pombe   708 RYKKVIQACGLLTDLQSFVASDLTEIGEKGVTLSGGQKQRIALARAVYSPTSIVLMDDVFSALDI 772

  Fly   569 HVGRHLFEECMR-GFLRDKLVILVTHQLQ-FLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKL 631
            |....:::.|.: ..:.::.||||||.:. |::.|..||.:..|....|
pombe   773 HTSNWIYKHCFQSSLMENRTVILVTHNVHLFMDSAAFIVTVKNGSAFPV---------------- 821

  Fly   632 LATEAQEMGDSNQEQVNAEGDSRNDKST----YSRQSSRVSRVSV---------TSVDSSTESIL 683
                                   .|||:    .:.|::..|..:.         ..||.:..:..
pombe   822 -----------------------TDKSSPLLFLAEQAASASEAAAPDLAAIPIPNEVDDAEAADE 863

  Fly   684 DNERQPAQESRSQGKIGLGIYGKYFS----AGSGWLMVILVAFFCL--GTQILASGGDYFLSYWV 742
            .:.:...:|.|..|.:   ::.:.||    .|||:.:..::.||..  .|.||.   |.::::|
pombe   864 KDGKLVEEEQRVTGDV---VFSEIFSYMKHFGSGFYVAAVLLFFVTTQATSILI---DLWVAFW- 921

  Fly   743 KNNDSSSSTDI------YIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFF 801
             .|.|.:|.|:      :::..:..|..:...|||:.:...|..:|.:||::|.:.|..|...:|
pombe   922 -TNSSVNSPDVNNNKFLFVYGTMLLAYSLLDFLRTVSYDRGAWWASRKLHDSMLESVFGTFASWF 985

  Fly   802 HANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITN--PWYLINTITMFLAFH 864
            ...|:|||:||||.|:..:|..|...:...|..||:::|  |:|.:::  |.::|..:.:.||.:
pombe   986 DKTPTGRIVNRFAKDIRSIDMNLSGWLFFSINCFLSVAG--GILSVSSAMPIFMIPAVIVCLAGY 1048

  Fly   865 FLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQ----DLLTKEYDNYQDIHSSG 925
            :....|......:|||.:|..||::|....::.|:|.|||...|    .:.::..||...:.|:.
pombe  1049 YFGLLYTRAQVGVKRLISIYTSPIFSLLGESIVGVSVIRAFNRQTIFKQMFSERLDNLVRLQSTS 1113

  Fly   926 YYTFLSTNRAFGYYLD-----LFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGM 985
            |    :.||......|     :..:|.:|::.....      :||.:|..:.||:..:.:|...:
pombe  1114 Y----NLNRWVAVRTDGISGLVGAIAGLIALLQKDL------SPGVVGFSLNQAVIFSSSVLLFV 1168

  Fly   986 RQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKP------PMNWPQEGLISAEQLSLRYNPDP 1044
            |....|:..|.|.||||||..|        |.:..|      |..||:||.|....:|:.|:  .
pombe  1169 RSCNSLQAEMNSYERVLEYSKL--------PQEPAPTIAGQVPATWPKEGDIVFNHVSVSYS--A 1223

  Fly  1045 KADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYN-EGSLVIDNTDILGIGLHDLRSK 1108
            ....:||.:|..|.|.||:.:|||||:|||:|...|.|.::. .|.:.|:..:...:.|:.||.:
pombe  1224 AGPTILKDVNLHINPSEKVAVVGRTGSGKSTLGLTLLRFTHRISGEIYINGRETQSVNLNALRQR 1288

  Fly  1109 ISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEE--------VHLKDEVSELPNGLESVVAEG 1165
            ||.|||:|:|||||:|.|||||::..|..|.|||:.        .|..|: ..:...|::.||..
pombe  1289 ISFIPQDPILFSGTVRSNLDPFDELEDNFLNEALKTSGASSMIMAHTDDQ-KPIHITLDTHVASE 1352

  Fly  1166 GSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTI 1230
            |||:|.||:|::.|||||:|.::|:::||.||:||...|..||.|:|..|.|.|:|.|||||.||
pombe  1353 GSNFSQGQKQVLALARAIVRRSKIIILDECTASVDDAMDQKIQKTLREAFGDATMLCIAHRLKTI 1417

  Fly  1231 IDSDRVMVLDAGTLVEFGSP 1250
            :|.|:|||||.|.|||:|.|
pombe  1418 VDYDKVMVLDKGVLVEYGPP 1437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	387/1320 (29%)
		ABC_membrane	92..362	CDD:294371	63/281 (22%)
		ABCC_MRP_domain1	412..611	CDD:213217	86/214 (40%)
		ABC_membrane	718..981	CDD:294371	72/281 (26%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	102/229 (45%)
abc4	NP_594558.1	CFTR_protein	240..1449	CDD:273530	383/1313 (29%)
		ABC_membrane	300..568	CDD:294371	63/278 (23%)
		ABCC_MRP_domain1	611..817	CDD:213217	86/205 (42%)
		ABC_membrane	901..1164	CDD:294371	72/279 (26%)
		ABCC_MRP_domain2	1210..1437	CDD:213211	102/229 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.900