DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc2

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_036965.1	Gene:	Abcc2 / 25303	RGDID:	2366	Length:	1541	Species:	Rattus norvegicus

Alignment Length:	1386	Identity:	460/1386 - (33%)
Similarity:	744/1386 - (53%)	Gaps:	159/1386 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSC----- 69
            |..:|...|::.|.:....:.||.|..|...|:::..:..|..::..||.|....:::..
  Rat   193 PSVTASFLSSITFSWYDRTVLKGYKHPLTLEDVWDIDEGFKTRSVTSKFEAAMTKDLQKARQAFQ 257

  Fly    70 ---------------GDSPKKEPS------------------------IIRVILKVFG---WQLF 92
                           |.:.|:..|                        :|:.:.|.|.   .:.|
  Rat   258 RRLQKSQRKPEATLHGLNKKQSQSQDVLVLEEAKKKSEKTTKDYPKSWLIKSLFKTFHVVILKSF 322

  Fly    93 LSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLW------AQIYGLTLILSILFSVLMFHP 151
            :..::..:|.......|.|::|     |.::.| ..:|      ..::.:|||.|........|.
  Rat   323 ILKLIHDLLVFLNPQLLKLLIG-----FVKSSN-SYVWFGYICAILMFAVTLIQSFCLQSYFQHC 381

  Fly   152 LMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGP 216
            .::|     |.:|..|.::||:|||.||..|....|.|:.|||:|.|..:...|..:...:|...
  Rat   382 FVLG-----MCVRTTVMSSIYKKALTLSNLARKQYTIGETVNLMSVDSQKLMDATNYMQLVWSSV 441

  Fly   217 LELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQ 281
            :::.:|.:||::::|.:.|.|:.:::|.:|:...|:.....::.|.....|:|:::||||:|||:
  Rat   442 IQITLSIFFLWRELGPSILAGVGVMVLLIPVNGVLATKIRNIQVQNMKNKDKRLKIMNEILSGIK 506

  Fly   282 VIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFV---SLLGFVLMGGEL 343
            ::|.:.||..|...::.:|:.|:.::.:...:: :||.|.:.::.|.:.|   |:...|.....|
  Rat   507 ILKYFAWEPSFQEQVQGIRKKELKNLLRFGQLQ-SLLIFILQITPILVSVVTFSVYVLVDSANVL 570

  Fly   344 TAERAFSVTAFYNILRRTVCKFFPSGM-----SQFAEMMVTLRRIKGFMMRSETEALYLKGGQTN 403
            .||:||:....:||||      ||..|     |...:..|::.|::.::...:.:...::
  Rat   571 NAEKAFTSITLFNILR------FPLSMLPMVTSSILQASVSVDRLERYLGGDDLDTSAIR----- 624

  Fly   404 KLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGES 468
            ::...:..||.......|:.| :|..::::|:.:.|.|||||:|.||||||||:.|:|||:....
  Rat   625 RVSNFDKAVKFSEASFTWDPD-LEATIQDVNLDIKPGQLVAVVGTVGSGKSSLVSAMLGEMENVH 688

  Fly   469 GKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGER 532
            |.:.:||..:|..|:.|:.|.:::||||||...::.:|:.|::.|||..|.|:| .||...:||:
  Rat   689 GHITIQGSTAYVPQQSWIQNGTIKDNILFGSEYNEKKYQQVLKACALLPDLEILPGGDMAEIGEK 753

  Fly   533 GASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQL 595
            |.:|||||:.|:|||||.|:.||.|:|||||||||.|||:|:|.:.:  .|.|..|..|.|||.:
  Rat   754 GINLSGGQKQRVSLARAAYQDADIYILDDPLSAVDAHVGKHIFNKVVGPNGLLAGKTRIFVTHGI 818

  Fly   596 QFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRND---- 656
            .||...|.||::.||.|...|:|.::|.....|.:...|..:..|...:..||.:.::.:|
  Rat   819 HFLPQVDEIVVLGKGTILEKGSYRDLLDKKGVFARNWKTFMKHSGPEGEATVNNDSEAEDDDDGL 883

  Fly   657 ----------------------KSTYSRQSSRVSR----------VSVTSVDSSTESILDNERQP 689
                                  :.|.||.|...||          :...:|....|..::.::..
  Rat   884 IPTMEEIPEDAASLAMRRENSLRRTLSRSSRSSSRRGKSLKNSLKIKNVNVLKEKEKEVEGQKLI 948

  Fly   690 AQESRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKN-------NDS 747
            .:|....||:...||.||..|...|.::.::.|:.| ..:...|.:.:||.|..:       |:|
  Rat   949 KKEFVETGKVKFSIYLKYLQAVGWWSILFIILFYGL-NNVAFIGSNLWLSAWTSDSDNLNGTNNS 1012

  Fly   748 SSSTD--IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRIL 810
            ||..|  |.:|..:..|..|..|:.||.......::|..||..:...:.|..:.||...|:|||:
  Rat  1013 SSHRDMRIGVFGALGLAQGICLLISTLWSIYACRNASKALHGQLLTNILRAPMRFFDTTPTGRIV 1077

  Fly   811 NRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSR 875
            |||:.|:..||::||..:...:..|..|:|.:.::|:..|.:.|..|.:.:.:..::.||::|||
  Rat  1078 NRFSGDISTVDDLLPQTLRSWMMCFFGIAGTLVMICMATPVFAIIIIPLSILYISVQVFYVATSR 1142

  Fly   876 DLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYL 940
            .|:||:::.:||:|||||.|:.||..|||.|.|.......:...||:....::::::||.....|
  Rat  1143 QLRRLDSVTKSPIYSHFSETVTGLPIIRAFEHQQRFLAWNEKQIDINQKCVFSWITSNRWLAIRL 1207

  Fly   941 DL------FCVAYVISV---TLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMT 996
            :|      ||.|.::.:   ||..         ..:|.|::.|:::|.|:.|.:|.::|.|.::.
  Rat  1208 ELVGNLVVFCSALLLVIYRKTLTG---------DVVGFVLSNALNITQTLNWLVRMTSEAETNIV 1263

  Fly   997 SVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPRE 1061
            :|||:.||.::|.|..:.:  ||:||.:||:.|.|......:||.|:  .|.|||.:...|...|
  Rat  1264 AVERISEYINVENEAPWVT--DKRPPADWPRHGEIQFNNYQVRYRPE--LDLVLKGITCNIKSGE 1324

  Fly  1062 KIGIVGRTGAGKSSLINALFR-LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRC 1125
            |:|:|||||||||||.|.||| |....|.::||..|:..|||||||.:::||||:|:||||:||.
  Rat  1325 KVGVVGRTGAGKSSLTNCLFRILESAGGQIIIDGIDVASIGLHDLRERLTIIPQDPILFSGSLRM 1389

  Fly  1126 NLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRIL 1190
            |||||.:|:||::|.|||..||:..||.|..||.|.|.|||.|.|:|||||:||.||:||:::||
  Rat  1390 NLDPFNKYSDEEVWRALELAHLRSFVSGLQLGLLSEVTEGGDNLSIGQRQLLCLGRAVLRKSKIL 1454

  Fly  1191 VMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLT 1255
            |:|||||.||.:||:|||:|||::|..|||:||||||:||:|||::||||.|.:||:|||.|||:
  Rat  1455 VLDEATAAVDLETDSLIQTTIRKEFSQCTVITIAHRLHTIMDSDKIMVLDNGKIVEYGSPEELLS 1519

  Fly  1256 QSWSKVFYGMVLQTGRSSFEH 1276
            ...|  ||.|..:.|..:..|
  Rat  1520 NRGS--FYLMAKEAGIENVNH 1538

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	454/1365 (33%)
		ABC_membrane	92..362	CDD:294371	75/278 (27%)
		ABCC_MRP_domain1	412..611	CDD:213217	93/201 (46%)
		ABC_membrane	718..981	CDD:294371	81/280 (29%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	129/221 (58%)
Abcc2	NP_036965.1	MRP_assoc_pro	7..1533	CDD:188098	458/1379 (33%)
		ABC_membrane	322..589	CDD:279056	76/284 (27%)
		ABCC_MRP_domain1	633..834	CDD:213217	93/201 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	862..881		4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	901..923		6/21 (29%)
		ABC_membrane	979..1245	CDD:279056	80/275 (29%)
		ABCC_MRP_domain2	1294..1514	CDD:213211	129/221 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345106
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660