DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcb4

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_036822.1	Gene:	Abcb4 / 24891	RGDID:	620248	Length:	1278	Species:	Rattus norvegicus

Alignment Length:	1373	Identity:	278/1373 - (20%)
Similarity:	561/1373 - (40%)	Gaps:	305/1373 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    74 KKEPSII--RVILKVFGWQLFLSGIVVGVLELGTRATLPL---ILGALIAEFTRN-GNGDGLWAQ 132
            ||:.::|  ..:.:...||..|..::...:.:...:.|||   :.|.:..:|..| ||
  Rat    31 KKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEMTDKFVDNAGN------- 88

  Fly   133 IYGLTLILSILFSVLMFHP-----------------LMMGLMHLAMKMRVAVSTAIYRKALRLSR 180
                 ..|.:.||:.|.:|                 |..|:: ||..::|:..|....:.:|..|
  Rat    89 -----FSLPVNFSLSMLNPGRILEEEMTRYAYYYSGLGGGVL-LAAYIQVSFWTLAAGRQIRKIR 147

  Fly   181 --------------------TALGDTTTGQVVNL---ISNDLGRFDRALIHFHFLWLGPLELLIS 222
                                |.|....|..:..:   |.:.:|.|.:|               |:
  Rat   148 QKFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQA---------------IA 197

  Fly   223 SYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRV-------RMMNEIISGI 280
            ::|....:|.  :.|..:.|:.:.|...|...|:......:..:|:.:       .:..|.:..|
  Rat   198 TFFAGFIVGF--IRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGAI 260

  Fly   281 QVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFVSLLGFVLMGGELTA 345
            :.:..:..:   .:.:||.:: .:.:.:|:...:....:..:.::.:.|:.|.......|..|..
  Rat   261 RTVIAFGGQ---NKELERYQK-HLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVI 321

  Fly   346 ERAFSV----TAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLF 406
            .:.:::    |.|::||   :..|   .:.|.|..:......:|        |.|:    ...:.
  Rat   322 SKEYTIGNAMTVFFSIL---IGAF---SVGQAAPCIDAFPNARG--------AAYV----IFDII 368

  Fly   407 EGEPLVKLQSFQARWNH-DHVE------------------PVLENINISLSPPQLVAVIGPVGSG 452
            :..|  |:.||..|.:. |.::                  .:|:.:|:.:...|.||::|..|.|
  Rat   369 DNNP--KIDSFSERGHKPDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCG 431

  Fly   453 KSSLIQAILGELPGESGKLKVQGD-------------ISYASQEPWLFNASVRDNILFG---LPM 501
            ||:.:|.:........|.:.:.|.             |...||||.||:.::.:||.:|   :.|
  Rat   432 KSTTVQLLQRLYDPTEGTISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTM 496

  Fly   502 DK--------HRYRNVIRNCALERDFELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYL 558
            |:        :.|..:::   |.:.|:      |.||:|||.|||||:.||::|||:.|.....|
  Rat   497 DEIKKAVKEANAYDFIMK---LPQKFD------TLVGDRGAQLSGGQKQRIAIARALVRNPKILL 552

  Fly   559 LDDPLSAVDTHVGRHL---FEECMRGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEE 620
            ||:..||:||.....:   .::...|    :..|::.|:|..:.:||:|...:.|.|...|::.|
  Rat   553 LDEATSALDTESEAEVQAALDKAREG----RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSE 613

  Fly   621 MLK---------SGQDFGKLLATEAQEMGDSNQEQVNAEGDS-------RNDKSTYSRQSSRVSR 669
            ::|         :.|..|..:.:|..|:..|:::.......:       ||.    :::|.:.||
  Rat   614 LIKKEGIYFRLVNMQTSGSQILSEEFEVELSDEKAAGGVAPNGWKARIFRNS----TKKSLKSSR 674

  Fly   670 VSVTSVDSSTESILDNERQPAQESR----SQGKIGLGIYGKYFSAGSGWLMVILVAFFCLGTQIL 730
            .....:|..|.. ||....|....:    ::.:....:.|...:..:|.|.   .||..:.::::
  Rat   675 AHQNRLDVETNE-LDANVPPVSFLKVLRLNKTEWPYFVVGTLCAIANGALQ---PAFSIILSEMI 735

  Fly   731 A---SGGDYFLSYWVKNNDSSSSTDIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQG 792
            |   .|.|     .||....:..:.:::..|:::....|  |:...|.......:|:|.:..|:.
  Rat   736 AIFGPGDD-----TVKQQKCNMFSLVFLGLGVHSFFTFF--LQGFTFGKAGEILTTRLRSMAFKA 793

  Fly   793 VSRTALYFF--HANPSGRILNRFAMDLGQVDEI----------------------------LPAV 827
            :.|..:.:|  |.|.:|.:..|.|.|..||...                            |..:
  Rat   794 MLRQDMSWFDDHKNSTGALSTRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLL 858

  Fly   828 MLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHF 892
            :|..:. |:.::||:.:..:..                      :..||.|.:||..:..
  Rat   859 LLSVVP-FIAVAGIVEMKMLAG----------------------NAKRDKKEMEAAGKIA----- 895

  Fly   893 SATLNGLSTIRAMEAQDLLTKEY---------DNYQDIHSSGYYTFLSTNRAFGYYLDLFCV--- 945
            :..:..:.|:.::..:......|         ::.:..|..| .|| |.::||.|:....|.
  Rat   896 TEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYG-ITF-SISQAFMYFSYAGCFRFG 958

  Fly   946 AYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAE 1010
            :|:|....|.:.:          :::..:..:.|.|..|...|...:.:...:.....:...|.:
  Rat   959 SYLIVNGHMRFKD----------VILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLFSLFERQ 1013

  Fly  1011 GEFESPDDKKPPMNWPQ--EGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGK 1073
            ...:|...:.   .||.  ||.::..::...| |......||:.|:..:...:.:.:||.:|.||
  Rat  1014 PLIDSYSREG---MWPDKFEGSVTFNEVVFNY-PTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1074

  Fly  1074 SSLINALFRLSYN--EGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNL---DPFEQY 1133
            |:::..|.|. |:  .|::::|..:...:.:..||:::.|:.|||:||..::..|:   |.....
  Rat  1075 STVVQLLERF-YDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYGDNSRVV 1138

  Fly  1134 ADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATAN 1198
            :.:::..|.:|.::...:..||...|:.|.:.|:..|.||:|.:.:|||::|:.|:|::||||:.
  Rat  1139 SQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLLLDEATSA 1203

  Fly  1199 VDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFY 1263
            :|.:::.::|..:.:.....|.:.|||||:||.::|.::|:|.|.:.|.|:..:||.|  ..:::
  Rat  1204 LDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQ--KGIYF 1266

  Fly  1264 GMV-LQTG 1270
            .|| :|.|
  Rat  1267 SMVNIQAG 1274

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	273/1357 (20%)
		ABC_membrane	92..362	CDD:294371	51/324 (16%)
		ABCC_MRP_domain1	412..611	CDD:213217	64/244 (26%)
		ABC_membrane	718..981	CDD:294371	49/307 (16%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	64/225 (28%)
Abcb4	NP_036822.1	PTZ00265	29..1271	CDD:240339	276/1368 (20%)
		ABC_membrane	58..342	CDD:279056	50/320 (16%)
		ABC_MTABC3_MDL1_MDL2	392..628	CDD:213216	64/248 (26%)
		Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	622..646		5/23 (22%)
		ABC_membrane	714..984	CDD:279056	51/319 (16%)
		ABC_MTABC3_MDL1_MDL2	1033..1272	CDD:213216	68/242 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000