DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Tap2

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_114445.2	Gene:	Tap2 / 24812	RGDID:	3818	Length:	703	Species:	Rattus norvegicus

Alignment Length:	691	Identity:	156/691 - (22%)
Similarity:	292/691 - (42%)	Gaps:	136/691 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 STYSRQSSRVSRVS---------VTSVDSSTESILD----NERQPAQESRSQGKIGLGIYGKYFS 709
            ||.|....||:..|         ..::..:..::|.    .|::|.||:.....|.|      ..
  Rat    85 STMSTSVLRVASASWGWLLAGYVAAALSLAVWAVLSPAGAQEKEPGQENNRALMIRL------LR 143

  Fly   710 AGSGWLMVILVAFFCL--------------GTQILASGGDYFLSYWVKNNDSSSSTDIY--IFS- 757
            .....|..::|||..|              |..|...|||:       :.|:.:|...:  :||
  Rat   144 LSKPDLPFLIVAFIFLAMAVWGETLIPHYSGRVIDILGGDF-------DPDAFASAIFFMCLFSV 201

  Fly   758 ------GINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMD 816
                  |......:|.:.|..|          ::...:|..:.|..|.||....:|.:.:|.:.|
  Rat   202 GSSLSAGCRGGSFLFTMSRINL----------RIREQLFSSLLRQDLAFFQETKTGELNSRLSSD 256

  Fly   817 LGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRD----- 876
            ...:...||   .:...:..::..::|:      :|.:..::..|.|..|....|:.:.:
  Rat   257 TSLMSRWLP---FNANILLRSLVKVVGL------YYFMLQVSPRLTFLSLLDLPLTIAAEKVYNP 312

  Fly   877 -----LKRL-EAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRA 935
                 ||.: :.:|::...  ....:.||.|:|:..|::         |::  |.|...|...|.
  Rat   313 RHQAVLKEIQDVVAKAGQV--VREAVGGLQTVRSFGAEE---------QEV--SRYKEALERCRQ 364

  Fly   936 FGYYLDLFCVAYVISVTLMSY-FNPPVDNPGQIGLVITQAMSMTGTVQWGMRQS----------- 988
            ..:..||....|::...:|:. ....:.|.| :..::...::..|.:.:.:.|.
  Rat   365 LWWRRDLEKELYLVIRRVMALGMQVLILNCG-VQQILAGEVTRGGLLSFLLYQEEVGHHVRNLVY 428

  Fly   989 --AELENSMTSVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLK 1051
              .::.:::.:.|:|..|  |:.......|....||.   .||.:..:.:|..|...|:.. ||:
  Rat   429 MYGDMLSNVGAAEKVFSY--LDRRPNLPKPGTLAPPR---VEGRVEFQDVSFSYPSRPEKP-VLQ 487

  Fly  1052 SLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNE--GSLVIDNTDILGIGLHDLRSKISIIPQ 1114
            .|.|.:.|.:...:||..|:|||: :.||.:..|..  |.:::|...::....|.|..::.::.|
  Rat   488 GLTFTLHPGKVTALVGPNGSGKST-VAALLQNLYQPTGGKVLLDGEPLVQYDHHYLHRQVVLVGQ 551

  Fly  1115 EPVLFSGTLRCNLD-PFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVC 1178
            |||||||:::.|:. ......|.::..|.:.....|.:.|:.||:.:.:.|.||..:|||:|.:.
  Rat   552 EPVLFSGSVKDNIAYGLRNCEDAQVMAAAQAACADDFIGEMTNGINTEIGERGSQLAVGQKQRLA 616

  Fly  1179 LARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGT 1243
            :|||::|..|:|::||||:.:|.:.:..:|:.  |...|.|:|.|||||:|:.::|:|:||..|.
  Rat   617 IARALVRNPRVLILDEATSALDAECEQALQTW--RSQEDRTMLVIAHRLHTVQNADQVLVLKQGQ 679

  Fly  1244 LVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLKLALEA 1284
            |||...                 |:..:..:.||::..|||
  Rat   680 LVEHDQ-----------------LRDEQDVYAHLVQQRLEA 703

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	150/662 (23%)
		ABC_membrane	92..362	CDD:294371
		ABCC_MRP_domain1	412..611	CDD:213217
		ABC_membrane	718..981	CDD:294371	53/297 (18%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	74/223 (33%)
Tap2	NP_114445.2	3a01208	1..697	CDD:273363	152/683 (22%)
		ABC_membrane	156..416	CDD:279056	51/299 (17%)
		P-loop_NTPase	457..680	CDD:304359	74/229 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000