DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Tap1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_114444.2	Gene:	Tap1 / 24811	RGDID:	3817	Length:	725	Species:	Rattus norvegicus

Alignment Length:	606	Identity:	140/606 - (23%)
Similarity:	252/606 - (41%)	Gaps:	130/606 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   715 LMVILVAFFCLGTQILASGGDYF---LSYWVKNNDSSSSTDIYIFSGINAALVIFALLRTLL--- 773
            |:::|:...|||...:    .:|   ::.|:..:.::.|     |:.....:.|..:..|.|
  Rat   166 LVLVLLILSCLGEMAI----PFFTGRITDWILQDKTAPS-----FARNMWLMCILTVASTALEFA 221

  Fly   774 ---FFSMAM-HSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQI 834
               .:::.| |..:::|..:|:.|......||..||:|.|.:|...|...|.|.:.    |.:.:
  Rat   222 GDGIYNITMGHMHSRVHGEVFRAVLHQETGFFLKNPTGSITSRVTEDTSNVCESIS----DKLNL 282

  Fly   835 FLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLST---------------------SRDLK 878
            ||              |||...:.: |||....:|||:.                     |..:|
  Rat   283 FL--------------WYLGRGLCL-LAFMIWGSFYLTVVTLLSLPLLFLLPRRLGKVYQSLAVK 332

  Fly   879 RLEAIARSPMYSHFSATLNGLSTIRAM-----EAQDLLTK--EYDNYQDIHSSGYYTFLSTNRAF 936
            ..|::|:|...:  ...|:.:.|:|:.     |||....|  |........:..|.|.:.|....
  Rat   333 VQESLAKSTQVA--LEALSAMPTVRSFANEEGEAQKFRQKLEEMKPLNKKEALAYVTEVWTMSVS 395

  Fly   937 GYYL---------DLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELE 992
            |..|         .|.....|.|..|:|:              :...:..|..|:..:.....::
  Rat   396 GMLLKVGILYLGGQLVVRGAVSSGNLVSF--------------VLYQLQFTRAVEVLLSIYPSMQ 446

  Fly   993 NSMTSVERVLEYRHLEAEGEFESPDDKKP---------PMNWPQEGLISAEQLSLRYNPDPKADR 1048
            .|:.:.|::.||.            |:.|         |:|  .:||:..:.:|..|...|.. :
  Rat   447 KSVGASEKIFEYL------------DRTPCSPLSGSLAPLN--MKGLVKFQDVSFAYPNHPNV-Q 496

  Fly  1049 VLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSYNE--GSLVIDNTDILGIGLHDLRSKISI 1111
            ||:.|.|.:.|.:...:||..|:|||: :.||.:..|..  |.:::|...::....|.|.::::.
  Rat   497 VLQGLTFTLYPGKVTALVGPNGSGKST-VAALLQNLYQPTGGKVLLDGELLVQYDHHYLHTQVAA 560

  Fly  1112 IPQEPVLFSGTLRCNLDPFEQY------ADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYS 1170
            :.|||:||..:.|.|:    .|      ..|::.....|....|.:|..|.|.::.|.|.|:..|
  Rat   561 VGQEPLLFGRSFRENI----AYGLTRTPTMEEITAVAMESGAHDFISGFPQGYDTEVGETGNQLS 621

  Fly  1171 VGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRR--KFRDCTVLTIAHRLNTIIDS 1233
            .||||.|.||||::|:.|:|::|:||:.:|......:|..:..  ::...|||.|..:|:....:
  Rat   622 GGQRQAVALARALIRKPRLLILDDATSALDAGNQLRVQRLLYESPEWASRTVLLITQQLSLAERA 686

  Fly  1234 DRVMVLDAGTLVEFGSPFELL 1254
            ..::.|..|::.|.|:..:|:
  Rat   687 HHILFLKEGSVCEQGTHLQLM 707

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	140/606 (23%)
		ABC_membrane	92..362	CDD:294371
		ABCC_MRP_domain1	412..611	CDD:213217
		ABC_membrane	718..981	CDD:294371	62/309 (20%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	67/230 (29%)
Tap1	NP_114444.2	3a01208	2..717	CDD:273363	140/606 (23%)
		ABC_membrane	177..435	CDD:279056	59/301 (20%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	352..397		10/44 (23%)
		Part of the peptide-binding site. /evidence=ECO:0000250\|UniProtKB:Q03518	430..464		7/45 (16%)
		P-loop_NTPase	469..697	CDD:304359	67/235 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000