DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc12

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_766500.3	Gene:	Abcc12 / 244562	MGIID:	2441679	Length:	1366	Species:	Mus musculus

Alignment Length:	1372	Identity:	437/1372 - (31%)
Similarity:	716/1372 - (52%)	Gaps:	169/1372 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDK-FFATWQSEVRS 68
            :|..||.:.||:.|...|.:..|::.:..|.|| ..|....|..:.:..:..| |...|:.|::.
Mouse    40 RLAPNPVDDAGLLSFATFSWLTPVMIRSYKHTL-TVDTLPPLSPYDSSDINAKRFQILWEEEIKR 103

  Fly    69 CGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLIL-GALIAEFTRNGNGD-GLWA 131
            .|  |:| .|:.||:.| |.....|..:|..:|.:...|..|.:| ..::...|...:|. |:
Mouse   104 VG--PEK-ASLGRVVWK-FQRTRVLMDVVANILCIVMAALGPTVLIHQILQHITSISSGHIGI-- 162

  Fly   132 QIYGLTLILSIL---FSVLMFHPLMMGLMH-LAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVV 192
               |:.|.|::.   |:.::|..|...:.: .|::::||:||.|:...  ||...|...:.|:|:
Mouse   163 ---GICLCLALFTTEFTKVLFWALAWAINYRTAIRLKVALSTLIFENL--LSFKTLTHISAGEVL 222

  Fly   193 NLISND-LGRFDRALIHFHFLWLG---PLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSR 253
            |::|:| ...|:.||    |..|.   |:.:::.:.:.:..:|..:|.||.:.|:|:|||.|:::
Mouse   223 NILSSDSYSLFEAAL----FCPLPATIPILMVVCAVYAFFILGSTALVGISVYLIFIPIQMFMAK 283

  Fly   254 LTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLL 318
            |.|..|......||:||:.|||.::.|::||||.||:.|...|..:|:.|...:.|..|::....
Mouse   284 LNSTFRRSAISVTDKRVQTMNEFLTCIKLIKMYAWEESFINTIHDIRKREKKLLEKAGYVQSGNS 348

  Fly   319 SFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRI 383
            :....:|.|||..:....:.:..:|||..||||.|.:|:::.::. ..|..:...||..|:|||:
Mouse   349 ALAPIVSTIAIVSTFTCHIFLKRKLTAPVAFSVIAMFNVMKFSIA-ILPFSVKAVAEASVSLRRM 412

  Fly   384 K---------GFMMRSETEALYLKGGQTNKLFEGE-------PLVKLQ-------------SFQA 419
            |         .::.:.|.....|........:|.|       |..::|             |.|:
Mouse   413 KKILIAKSPPSYITQPEDPDTILLLANATLTWEQEINRKSDPPKAQIQKRHVFKKQRPELYSEQS 477

  Fly   420 R---------WNHDHVEPVLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQG 475
            |         |.....:.||.||:..:...:::.:.|.|||||||||.|:||::..:.|.:.|.|
Mouse   478 RSDQGVASPEWQSGSPKSVLHNISFVVRKGKVLGICGNVGSGKSSLISALLGQMQLQKGVVAVNG 542

  Fly   476 DISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGG 539
            .::|.||:.|:|:.:||:|||||...:..||::.:..|.|::|...| :||.|.:||||.:||||
Mouse   543 PLAYVSQQAWIFHGNVRENILFGEKYNHQRYQHTVHVCGLQKDLNSLPYGDLTEIGERGVNLSGG 607

  Fly   540 QRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDKLVILVTHQLQFLEHADLI 604
            ||.|||||||||.....|||||||||||.|||:|:||||::..|:.|.|:||||||||||..|.:
Mouse   608 QRQRISLARAVYANRQLYLLDDPLSAVDAHVGKHVFEECIKKTLKGKTVVLVTHQLQFLESCDEV 672

  Fly   605 VIMDKGKISAVGTYEEMLKSGQDFGKLL--------------------ATEAQEMGDSNQEQVNA 649
            ::::.|:|...||::|:::....:.||:                    .|..:.....:::.|.|
Mouse   673 ILLEDGEICEKGTHKELMEERGRYAKLIHNLRGLQFKDPEHIYNVAMVETLKESPAQRDEDAVLA 737

  Fly   650 EGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQ----ESRSQGKIGLGIYGKYFSA 710
            .||.:::                 ..:..||..:|......|    ||..:|.:....|..|..|
Mouse   738 SGDEKDE-----------------GKEPETEEFVDTNAPAHQLIQTESPQEGIVTWKTYHTYIKA 785

  Fly   711 GSGWLMVILVAFFCLGTQILASGGDYFLSYWV--------------KNNDSSSSTD--------- 752
            ..|:|:..||  .||  ..|..|...|.::|:              :||.::.:.|
Mouse   786 SGGYLVSFLV--LCL--FFLMMGSSAFSTWWLGIWLDRGSQVVCASQNNKTACNVDQTLQDTKHH 846

  Fly   753 ----IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRF 813
                :||.|.:  ::::|.:::...|.:..:.:|:.|||.:|..:.|:.:.||...|:||::|||
Mouse   847 MYQLVYIASMV--SVLMFGIIKGFTFTNTTLMASSSLHNRVFNKIVRSPMSFFDTTPTGRLMNRF 909

  Fly   814 AMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLK 878
            :.|:.::|..||....:.:|.|..:..|:.::....|..|:....:.:.|..|...:....::||
Mouse   910 SKDMDELDVRLPFHAENFLQQFFMVVFILVIMAAVFPVVLVVLAGLAVIFLILLRIFHRGVQELK 974

  Fly   879 RLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDL- 942
            ::|.|:|||.:||.::::.||..|.|.:.:|....::....|.:||....|....|.|...:|:
Mouse   975 QVENISRSPWFSHITSSIQGLGVIHAYDKKDDCISKFKTLNDENSSHLLYFNCALRWFALRMDIL 1039

  Fly   943 -----FCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVL 1002
                 |.||.:::::..|.      :....||.::..:.::|.:|..:|...|.:...||.|.:.
Mouse  1040 MNIVTFVVALLVTLSFSSI------SASSKGLSLSYIIQLSGLLQVCVRTGTETQAKFTSAELLR 1098

  Fly  1003 EYRHLEAEGEFESPDDKKP------PMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPRE 1061
            ||.....      |:...|      |.:||..|.|:.:...:||..:  ...||..||..|...:
Mouse  1099 EYILTCV------PEHTHPFKVGTCPKDWPSRGEITFKDYRMRYRDN--TPLVLDGLNLNIQSGQ 1155

  Fly  1062 KIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRC 1125
            .:|||||||:|||||..||||| ....|:::||..||..:||.|||:|:::|||:||||.||:|.
Mouse  1156 TVGIVGRTGSGKSSLGMALFRLVEPASGTIIIDEVDICTVGLEDLRTKLTMIPQDPVLFVGTVRY 1220

  Fly  1126 NLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRIL 1190
            ||||...:.||.||..||...::|.:.:||..|::.|.|.|.|:|||:|||:|:|||:||.::|:
Mouse  1221 NLDPLGSHTDEMLWHVLERTFMRDTIMKLPEKLQAEVTENGENFSVGERQLLCMARALLRNSKII 1285

  Fly  1191 VMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLT 1255
            ::|||||::|.:||.|:||||:..|:.||||||||||||:::.|.|:|::.|.::||..| |:|.
Mouse  1286 LLDEATASMDSKTDTLVQSTIKEAFKSCTVLTIAHRLNTVLNCDLVLVMENGKVIEFDKP-EVLA 1349

  Fly  1256 QSWSKVF 1262
            :.....|
Mouse  1350 EKPDSAF 1356

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	436/1364 (32%)
		ABC_membrane	92..362	CDD:294371	81/279 (29%)
		ABCC_MRP_domain1	412..611	CDD:213217	98/221 (44%)
		ABC_membrane	718..981	CDD:294371	69/295 (23%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	110/221 (50%)
Abcc12	NP_766500.3	MRP_assoc_pro	43..1366	CDD:188098	436/1369 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	470..492		4/21 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	726..749		4/39 (10%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841702
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.660