Protein Alignment CG9270 and Abcc4

DIOPT Version :10

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: NP_001028508.2
• Gene: Abcc4 / 239273
• MGIID: 2443111
• Length: 1325
• Species: Mus musculus
• Alignment Length: 1319
• Identity: 587/1319 - (44%)
• Similarity: 838/1319 - (63%)
• Gaps: 65/1319 - (4%)

  Fly     5 KLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE-VRS 68
            :::.||.:.|.:.|.:.|.:..|:...|.|:.||..|:::.|.|.:::.||::....|..| :|:
Mouse     7 EVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRA 71

  Fly    69 CGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGL---- 129
            ..||  ::||:.:.|:|.: |:.:|...:..::|.|||...||.||.:|..|.:....|.:
Mouse    72 KKDS--RKPSLTKAIIKCY-WKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHT 133

  Fly   130 ---WAQIYGL-TLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQ 190
               :|.:..: ||||:||..:..:|....|     |::|||:...|||||||||.:|:|.|||||
Mouse   134 AYGYAAVLSMCTLILAILHHLYFYHVQCAG-----MRLRVAMCHMIYRKALRLSNSAMGKTTTGQ 193

  Fly   191 VVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLT 255
            :|||:|||:.:||:..|..||||.|||:.:..:..|:.:||::.|.|:.:|::.||:|:.:.:|.
Mouse   194 IVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLF 258

  Fly   256 SRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSF 320
            |.||.:||..||.|:|.|||:|:|:::||||.|||.|..||..||:.|:|.|...:|:||..::.
Mouse   259 SSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMAS 323

  Fly   321 EITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKG 385
            ....:::.:||:...:||:|.|:||...|.....|..:|.||..||||.:.:.:|.:|::||||.
Mouse   324 FFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKN 388

  Fly   386 FMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVG 450
            |::..|     |...:.:...:|:.:|.:|.|.|.|:.....|.|:.::....|.:|:||:||||
Mouse   389 FLLLDE-----LPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVG 448

  Fly   451 SGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCAL 515
            :|||||:.|:|||||..||.:.|.|.|:|.||:||:|:.:||.|||||...:|.||..||:.|||
Mouse   449 AGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACAL 513

  Fly   516 ERDFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM 579
            ::|.:||. ||.|.:|:|||:|||||:||::||||||:.||.|||||||||||..||:|||:.|:
Mouse   514 KKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCI 578

  Fly   580 RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQ 644
            ...|.:|:.||||||||:|:.|..|:|:..|::...|||.|.||||.|||.||..|.:|     .
Mouse   579 CQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEE-----A 638

  Fly   645 EQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDN--ERQPA--------QESRSQGKI 699
            |...|.|.....|.|:       |..|:.|..||..|:.|.  |.|.|        :||||:|:|
Mouse   639 EPSTAPGTPTLRKRTF-------SEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRI 696

  Fly   700 GLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVK-----NNDSSSSTDIY----- 754
            |...|..|||||:.|..:|.:....:..|:.....|::||:|..     ||..:::.:|.
Mouse   697 GFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNITETLDL 761

  Fly   755 -----IFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFA 814
                 |::|:.|..|:|.:.|:||.|.:.:::|..|||.||:.:.:..:.||..||.|||||||:
Mouse   762 SWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFS 826

  Fly   815 MDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKR 879
            .|:|.:|::||...||.||..|.:..:|.|.....||.||..:.:.:.|..||.::|.||||:||
Mouse   827 KDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKR 891

  Fly   880 LEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFC 944
            ||:..|||::||.|::|.||.||||.:|::...:.:|.:||:||..::.||:|:|.|...||..|
Mouse   892 LESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAIC 956

  Fly   945 VAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEA 1009
            ..:||.|...|.......|.||:||.::.|:::.|..||.:|||||:||.|.|||||:||..||.
Mouse   957 AIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEK 1021

  Fly  1010 EGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKS 1074
            |..:|.  .|:||..||.||:|..:.::..|:.|  ...|||.|..:|..|||:|||||||||||
Mouse  1022 EAPWEC--KKRPPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALIKSREKVGIVGRTGAGKS 1082

  Fly  1075 SLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLW 1139
            |||:||||||..||.:.||......|||||||.|:||||||||||:||:|.|||||.::.||:||
Mouse  1083 SLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELW 1147

  Fly  1140 EALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1204
            .|||||.||:.:.:||..:::.:||.|||:|||||||||||||||:.||||::|||||||||:||
Mouse  1148 RALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTD 1212

  Fly  1205 ALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQT 1269
            .|||..||.||..|||||||||||||||||::||||:|.|.|:..|:.|| |:...:||.||.|.
Mouse  1213 ELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL-QNPESLFYKMVQQL 1276

  Fly  1270 GRSSFEHLLKLALEAHERR 1288
            |:.....|.:.|.:.:.||
Mouse  1277 GKGEAAALTETAKQVYFRR 1295

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	PLN03130	10..1289	CDD:215595	586/1314 (45%)
Abcc4	NP_001028508.2	PLN03130	12..1284	CDD:215595	582/1301 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	657..690		9/32 (28%)
		PDZ-binding. /evidence=ECO:0000250|UniProtKB:O15439	1322..1325