DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc4

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001028508.2	Gene:	Abcc4 / 239273	MGIID:	2443111	Length:	1325	Species:	Mus musculus

Alignment Length:	1319	Identity:	587/1319 - (44%)
Similarity:	838/1319 - (63%)	Gaps:	65/1319 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSE-VRS 68
            :::.||.:.|.:.|.:.|.:..|:...|.|:.||..|:::.|.|.:::.||::....|..| :|:
Mouse     7 EVKPNPLQDANLCSRVFFWWLNPLFKTGHKRRLEEDDMFSVLPEDRSKHLGEELQRYWDKELLRA 71

  Fly    69 CGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGL---- 129
            ..||  ::||:.:.|:|.: |:.:|...:..::|.|||...||.||.:|..|.:....|.:
Mouse    72 KKDS--RKPSLTKAIIKCY-WKSYLILGIFTLIEEGTRVVQPLFLGKIIEYFEKYDPDDSVALHT 133

  Fly   130 ---WAQIYGL-TLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQ 190
               :|.:..: ||||:||..:..:|....|     |::|||:...|||||||||.:|:|.|||||
Mouse   134 AYGYAAVLSMCTLILAILHHLYFYHVQCAG-----MRLRVAMCHMIYRKALRLSNSAMGKTTTGQ 193

  Fly   191 VVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLT 255
            :|||:|||:.:||:..|..||||.|||:.:..:..|:.:||::.|.|:.:|::.||:|:.:.:|.
Mouse   194 IVNLLSNDVNKFDQVTIFLHFLWAGPLQAIAVTVLLWVEIGISCLAGLAVLVILLPLQSCIGKLF 258

  Fly   256 SRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSF 320
            |.||.:||..||.|:|.|||:|:|:::||||.|||.|..||..||:.|:|.|...:|:||..::.
Mouse   259 SSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLIANLRKKEISKILGSSYLRGMNMAS 323

  Fly   321 EITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKG 385
            ....:::.:||:...:||:|.|:||...|.....|..:|.||..||||.:.:.:|.:|::||||.
Mouse   324 FFIANKVILFVTFTSYVLLGNEITASHVFVAMTLYGAVRLTVTLFFPSAIERGSEAIVSIRRIKN 388

  Fly   386 FMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVG 450
            |::..|     |...:.:...:|:.:|.:|.|.|.|:.....|.|:.::....|.:|:||:||||
Mouse   389 FLLLDE-----LPQRKAHVPSDGKAIVHVQDFTAFWDKALDSPTLQGLSFIARPGELLAVVGPVG 448

  Fly   451 SGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCAL 515
            :|||||:.|:|||||..||.:.|.|.|:|.||:||:|:.:||.|||||...:|.||..||:.|||
Mouse   449 AGKSSLLSAVLGELPPASGLVSVHGRIAYVSQQPWVFSGTVRSNILFGKKYEKERYEKVIKACAL 513

  Fly   516 ERDFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM 579
            ::|.:||. ||.|.:|:|||:|||||:||::||||||:.||.|||||||||||..||:|||:.|:
Mouse   514 KKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCI 578

  Fly   580 RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQ 644
            ...|.:|:.||||||||:|:.|..|:|:..|::...|||.|.||||.|||.||..|.:|     .
Mouse   579 CQALHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEE-----A 638

  Fly   645 EQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDN--ERQPA--------QESRSQGKI 699
            |...|.|.....|.|:       |..|:.|..||..|:.|.  |.|.|        :||||:|:|
Mouse   639 EPSTAPGTPTLRKRTF-------SEASIWSQQSSRPSLKDGAPEGQDAENTQAVQPEESRSEGRI 696

  Fly   700 GLGIYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVK-----NNDSSSSTDIY----- 754
            |...|..|||||:.|..:|.:....:..|:.....|::||:|..     ||..:::.:|.
Mouse   697 GFKAYKNYFSAGASWFFIIFLVLLNMVGQVFYVLQDWWLSHWANKQGALNNTRNANGNITETLDL 761

  Fly   755 -----IFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFA 814
                 |::|:.|..|:|.:.|:||.|.:.:::|..|||.||:.:.:..:.||..||.|||||||:
Mouse   762 SWYLGIYAGLTAVTVLFGIARSLLVFYILVNASQTLHNRMFESILKAPVLFFDRNPIGRILNRFS 826

  Fly   815 MDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKR 879
            .|:|.:|::||...||.||..|.:..:|.|.....||.||..:.:.:.|..||.::|.||||:||
Mouse   827 KDIGHMDDLLPLTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSVVFLVLRRYFLETSRDVKR 891

  Fly   880 LEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFC 944
            ||:..|||::||.|::|.||.||||.:|::...:.:|.:||:||..::.||:|:|.|...||..|
Mouse   892 LESTTRSPVFSHLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAIC 956

  Fly   945 VAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEA 1009
            ..:||.|...|.......|.||:||.::.|:::.|..||.:|||||:||.|.|||||:||..||.
Mouse   957 AIFVIVVAFGSLVLAKTLNAGQVGLALSYALTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEK 1021

  Fly  1010 EGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKS 1074
            |..:|.  .|:||..||.||:|..:.::..|:.|  ...|||.|..:|..|||:|||||||||||
Mouse  1022 EAPWEC--KKRPPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALIKSREKVGIVGRTGAGKS 1082

  Fly  1075 SLINALFRLSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLW 1139
            |||:||||||..||.:.||......|||||||.|:||||||||||:||:|.|||||.::.||:||
Mouse  1083 SLISALFRLSEPEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHTDEELW 1147

  Fly  1140 EALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1204
            .|||||.||:.:.:||..:::.:||.|||:|||||||||||||||:.||||::|||||||||:||
Mouse  1148 RALEEVQLKEAIEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKNNRILIIDEATANVDPRTD 1212

  Fly  1205 ALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQT 1269
            .|||..||.||..|||||||||||||||||::||||:|.|.|:..|:.|| |:...:||.||.|.
Mouse  1213 ELIQQKIREKFAQCTVLTIAHRLNTIIDSDKIMVLDSGRLKEYDEPYVLL-QNPESLFYKMVQQL 1276

  Fly  1270 GRSSFEHLLKLALEAHERR 1288
            |:.....|.:.|.:.:.||
Mouse  1277 GKGEAAALTETAKQVYFRR 1295

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	576/1285 (45%)
		ABC_membrane	92..362	CDD:294371	110/277 (40%)
		ABCC_MRP_domain1	412..611	CDD:213217	108/199 (54%)
		ABC_membrane	718..981	CDD:294371	101/277 (36%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	141/220 (64%)
Abcc4	NP_001028508.2	PLN03130	12..1284	CDD:215595	582/1301 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	657..690		9/32 (28%)
		PDZ-binding. /evidence=ECO:0000250\|UniProtKB:O15439	1322..1325
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841680
Domainoid	1	1.000	232	1.000	Domainoid score	I2403
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1109	1.000	Inparanoid score	I229
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm42331
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810