DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc10

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001334325.1	Gene:	Abcc10 / 224814	MGIID:	2386976	Length:	1526	Species:	Mus musculus

Alignment Length:	1369	Identity:	439/1369 - (32%)
Similarity:	696/1369 - (50%)	Gaps:	190/1369 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 STLMFCFALPILFKG-RKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPKKEPSIIR 81
            |...:.:..|:|.:| |.:..:|.|.....:......|...|.|.|           |:...:.|
Mouse   223 SRFSYAWLAPLLARGVRGELQQPRDTCRLPRRLHPAFLARVFQAHW-----------KEGAQLWR 276

  Fly    82 VILKVFGWQLFLSGI--VVGVLELGTRATLPLILGALIAEFTRNGNGDGLWAQIYGLTLILSILF 144
            .:.:.||......|:  :||.: ||...  ||:|..|:. |...|........:|.|.|....:.
Mouse   277 ALYRAFGCCYLALGLLKMVGTM-LGFSG--PLLLSLLVG-FLEEGQEPLSHGLLYVLGLAGGTVI 337

  Fly   145 SVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHF 209
            |.::.:.....:..:.::.||||.:.:|||||:|..:.   ..||:|:||:..|..|.......|
Mouse   338 SAVLQNQYGYEVRKVTLQARVAVLSTLYRKALKLGPSR---PPTGEVLNLLGTDSERLLNFAGSF 399

  Fly   210 HFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPI-QTFLSRLTS----RLRHQTALRTDQR 269
            |..|..||:|.|:.|.||||:|:|.|.|:|:.||.:|: :...:|:.:    .|||:     |.|
Mouse   400 HEAWGLPLQLAITLYLLYQQVGMAFLAGLVLALLLVPVNKVIATRIMASNQEMLRHK-----DAR 459

  Fly   270 VRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFVSLL 334
            |::|.|::|||:|||.:.||:..|..::..|..|:..:|.:.|:....:.....|..:......:
Mouse   460 VKLMTELLSGIRVIKFFRWEQALGDRVKACRTKELGRLRVIKYLDAACVYLWAALPVVICITIFI 524

  Fly   335 GFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFM-MRSETEALYLK 398
            .:||||.:|||.:.|:..|...:|...: ..||..::...|..|:|.||:.|: :.|.:...|..
Mouse   525 TYVLMGHQLTATKVFTALALVRMLILPL-NNFPWVINGLLESKVSLDRIQRFLDLPSYSPEAYYS 588

  Fly   399 GGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENI--NISLSPPQLVAVIGPVGSGKSSLIQAIL 461
            ...     ..||...|:..:|.::.|.:....:..  ::.:....||.::|.||.|||||:.||.
Mouse   589 PDP-----PAEPSTALELHEALFSWDPIGASQKTFISHLQVKKGMLVGIVGKVGCGKSSLLAAIT 648

  Fly   462 GELPGESGKLKVQGDIS----YASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL 522
            |||....|.:.| .::|    .|:||||:..|::|||||||...|...||.|:..|||..|..:|
Mouse   649 GELHRLCGWVAV-SELSKGFGLATQEPWIQCATIRDNILFGKTFDAQLYREVLEACALNDDLSIL 712

  Fly   523 -HGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRDK 586
             .||:|.|||:|.:|||||||||:||||||::...|||||||:|||..|..||...|:.|.|...
Mouse   713 PAGDQTEVGEKGVTLSGGQRARIALARAVYQEKALYLLDDPLAAVDADVANHLLHRCILGVLSHT 777

  Fly   587 LVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEG 651
            ..:|.||:.::||.||::::|:.|::...|...|:|.         ..:|.....:.:|||...|
Mouse   778 TRLLCTHRTEYLERADVVLLMEAGQLVRTGPPSEILP---------LVQAVPTAWAEKEQVATSG 833

  Fly   652 DSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPA-----QESRSQGKIGLGIYGKYFSA- 710
            .|                .||..::.:||..|:.|:...     :||:|:|.:.|.:|..|:.|
Mouse   834 QS----------------PSVCDLERTTEEELEVEQSTCGCLVQEESKSEGAVALHVYRAYWRAM 882

  Fly   711 GSGWLMVILVAFFCLGTQILASGGDYFLSYWV------KNND----------------------- 746
            |||....|||:...:  |...:|.|::|::|:      :|..
Mouse   883 GSGLAAAILVSLLLM--QATRNGADWWLAHWLSQLKAGRNGSREDPASCSPGSTALFSPRLLLFS 945

  Fly   747 -----------------SSSSTDIYIF-------SGINAALVIFALLRTLLFFSMAMHSSTQLHN 787
                             |:.:.|::.:       :|:|:   :..|||.:||.:.|:.::..||:
Mouse   946 PGNLYTPLLSTPLHKAASNGTADVHFYLIVYATIAGVNS---LCTLLRAVLFAAGALQAAASLHH 1007

  Fly   788 TMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTIS-GIIGVLCITN-- 849
            .:...:....:.|:.:.||||:||||:.|:..||:.||.:    :.|.|..| |::|:|.:..
Mouse  1008 RLLHRLLMAPVTFYDSTPSGRVLNRFSSDVACVDDSLPFL----LNILLANSVGLLGLLAVLGSG 1068

  Fly   850 -PWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTK 913
             ||.|:....:...::.::.:|.::.|:|:||.::..||:|||.:.||.||..:||..|.....:
Mouse  1069 LPWLLLLLPPLSFVYYSVQGYYRASFRELRRLGSLTWSPLYSHLADTLAGLPVLRAAGATYRFEE 1133

  Fly   914 EYDNYQDIHSSGYYTFLSTNRAFGYYLDLF---CVAYVISVTLMSYFNPPVDNPGQIGLVITQAM 975
            |.....:::....:...:|.:.....|.|.   .|:.:..:.|:.: ...:.|||.:|||::.|:
Mouse  1134 ENQRLLELNQRCQFASYATMQWLDIRLQLMGAAVVSAIAGIALVQH-QQGLANPGLVGLVLSYAL 1197

  Fly   976 SMTGTVQWGMRQSAELENSMTSVERVLEYR-------HLEAEGEFESPDDKKPPMNWPQEGLISA 1033
            |:||.:...:....:.|..|.||||:.||.       |.:   ..:||..::  ::|..:|.:..
Mouse  1198 SLTGLLSGLVSSFTQTEAMMVSVERLEEYSCDVPQEPHSQ---PLQSPHQQR--ISWLTQGSVEF 1257

  Fly  1034 EQLSLRYNPD-PKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR-LSYNEGSLVIDNTD 1096
            :.:.|.|.|. |.|   |..:.|.:.|.||:|||||||:|||||...||| |..|.|.:::||.|
Mouse  1258 QDVVLVYRPGLPNA---LDGVTFRVEPGEKLGIVGRTGSGKSSLFLVLFRLLEPNAGRVLLDNVD 1319

  Fly  1097 ILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEV---------- 1151
            ...:.|.:|||::::|||||.|||||:|.||||...:.|..||:|||:.||.:..
Mouse  1320 TSQLELAELRSQLAVIPQEPFLFSGTIRENLDPQGLHEDRALWQALEQCHLSEVAVAMGESQACQ 1384

  Fly  1152 --------------SELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQ 1202
                          :.|..||:..:.|.|.|.|:|||||:|||||:|.:.:||.:|||||:||.:
Mouse  1385 RSQREAKNGHWQCSALLTGGLDGELGERGQNLSLGQRQLLCLARALLTDAKILCIDEATASVDQK 1449

  Fly  1203 TDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVL 1267
            ||.|:|.||.::|.:.||||||||||||::||||:||.||.:||..||..|..|..|  .:..:|
Mouse  1450 TDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPSALRNQPHS--LFQQLL 1512

  Fly  1268 QTGR 1271
            |:.:
Mouse  1513 QSSQ 1516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	435/1353 (32%)
		ABC_membrane	92..362	CDD:294371	85/276 (31%)
		ABCC_MRP_domain1	412..611	CDD:213217	89/205 (43%)
		ABC_membrane	718..981	CDD:294371	77/322 (24%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	115/246 (47%)
Abcc10	NP_001334325.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841742
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.650