DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc8

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	XP_036008753.1	Gene:	Abcc8 / 20927	MGIID:	1352629	Length:	1597	Species:	Mus musculus

Alignment Length:	1376	Identity:	415/1376 - (30%)
Similarity:	680/1376 - (49%)	Gaps:	199/1376 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    50 KAETLGDKFFATWQSEVRSCGDSPKKEPSIIRVILKVFGWQLFLSG---IVVGVLELGTRATLPL 111
            :|.|...:..|.:.::.|....|.:...:|.|.:...||.:|.||.   |:..:|....    ||
Mouse   258 RALTNYQRLCAAFDAQARKDTQSQQGARAIWRALCHAFGRRLVLSSTFRILADLLGFAG----PL 318

  Fly   112 ILGALIAEFTRNGNGDGLWAQIYGLTLILS-------ILFSVLMFHPLMMGLMHL---------- 159
            .:..::....:..:......|..|:..:.|       .:.:||:|..|::....|
Mouse   319 CIFGIVDHLGKENHVFQPKTQFLGVYFVSSQEFLGNAYVLAVLLFLALLLQRTFLQASYYVAIET 383

  Fly   160 AMKMRVAVSTAIYRKALRLSRT--ALGDTTTGQVVNLISNDLGRFDRALIHFHF----LWLGPLE 218
            .:.:|.|:.|.||.|.:.||.:  ::|:.|.||:.||::.|..:    |:.|.|    ||..|::
Mouse   384 GINLRGAIQTKIYNKIMHLSTSNLSMGEMTAGQICNLVAIDTNQ----LMWFFFLCPNLWAMPVQ 444

  Fly   219 LLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVI 283
            :::....||..:||::|.|..:::|..|:|.|::...|:.:..|...:::|::..||::.||:::
Mouse   445 IIVGVILLYYILGVSALIGAAVIILLAPVQYFVATKLSQAQRSTLEYSNERLKQTNEMLRGIKLL 509

  Fly   284 KMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIAIFVSLLGFV--LMGGELTAE 346
            |:|.||..|...:|..||.||:|:|.........:.....:...|:.::.:|.|  ....:.:..
Mouse   510 KLYAWENIFCSRVEMTRRKEMTSLRAFAVYTSISIFMNTAIPIAAVLITFVGHVSFFKESDFSPS 574

  Fly   347 RAFSVTAFYNILRRTVCKFF--PSGMSQFAEMMVTLRRIKGFMMRSET----------------- 392
            .||:..:.::||   |...|  .|.:....:.:|:::::..|:..:|.
Mouse   575 VAFASLSLFHIL---VTPLFLLSSVVRSTVKALVSVQKLSEFLSSAEIREEQCAPREPAPQGQAG 636

  Fly   393 --EALYLKGGQTNKLFEGE------PLVKL--------QSFQAR-------WNHDHVEPVLENIN 434
              :|:.||.....:....|      ||.:|        .:|..:       |..|.: |.|.||.
Mouse   637 KYQAVPLKVVNRKRPAREEVRDLLGPLQRLTPSMDGDADNFCVQIIGGFFTWTPDGI-PTLSNIT 700

  Fly   435 ISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKL---------------------------- 471
            |.:...||..::|.||.|||||:.|.|||:...||.:
Mouse   701 IRIPRGQLTMIVGQVGCGKSSLLLATLGEMQRVSGAVFWNSSLPDSEGEDPRYCLRTSNPERETA 765

  Fly   472 -----KVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVG 530
                 :.:|.::||||:|||.||:|.:||.|..|.:|.||:.||..|:|:.|.::| |||:|.:|
Mouse   766 ADSDARSRGPVAYASQKPWLLNATVEENITFESPFNKQRYKMVIEACSLQPDIDILPHGDQTQIG 830

  Fly   531 ERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECMRGFLRD--KLVILVTH 593
            |||.:||||||.|||:|||:|:..:...||||.||:|.|:..||.:..:...|||  :.|:||||
Mouse   831 ERGINLSGGQRQRISVARALYQHTNVVFLDDPFSALDVHLSDHLMQAGILELLRDDKRTVVLVTH 895

  Fly   594 QLQFLEHADLIVIMDKGKISAVGTYEEMLKSG----QDFGKLLATEAQEMGDSNQEQVNAEGDSR 654
            :||:|.|||.|:.|..|.|...||.::..:|.    :.:..|:..:.||:
Mouse   896 KLQYLPHADWIIAMKDGTIQREGTLKDFQRSECQLFEHWKTLMNRQDQEL--------------- 945

  Fly   655 NDKSTYSRQSSRVSRVSVTSVDSSTESIL---DNERQPAQES----------RSQGKIGLGIYGK 706
             :|.|...:.:......:....||.:.:|   |.|.:.|.||          ..:.||......|
Mouse   946 -EKETVMERKAPEPSQGLPRAMSSRDGLLLDEDEEEEEAAESEEDDNLSSVLHQRAKIPWRACTK 1009

  Fly   707 YFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKN--------NDSSSSTDIYIFSGINAAL 763
            |.|: :|.|::.|:.|..|...::....||:|:.|..:        .:.|.|.:..:...:.|
Mouse  1010 YLSS-AGVLLLSLLVFSQLLKHMVLVAIDYWLAKWTDSALVLSPAARNCSLSQECALDQSVYA-- 1071

  Fly   764 VIFALLRTLLFFSMAMHSST----------QLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLG 818
            ::|.:|.:|......:.|.|          :||.::...:....:.||...|.|.|||||:.|..
Mouse  1072 MVFTVLCSLGIALCLVTSVTVEWTGLKVAKRLHRSLLNRIILAPMRFFETTPLGSILNRFSSDCN 1136

  Fly   819 QVDEILPAVMLDCI--QIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLE 881
            .:|:.:|:. |:|:  ...|.:|.:. |:....|.:|:..:.:.:..:|::.::...||||::|:
Mouse  1137 TIDQHIPST-LECLSRSTLLCVSALT-VISYVTPVFLVALLPLAVVCYFIQKYFRVASRDLQQLD 1199

  Fly   882 AIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDL---- 942
            ...:.|:.|||:.|:.||:||||...:....::...|.|.::.......:.||    :|::
Mouse  1200 DTTQLPLLSHFAETVEGLTTIRAFRYEARFQQKLLEYTDSNNIASLFLTAANR----WLEVRMPG 1260

  Fly   943 -----------FCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMT 996
                       .||..:.:.|.:|.......:.|.:||.:|.|:.::..:.|.:|..|::|..:.
Mouse  1261 PAAVLPQEYIGACVVLIAAATSISNSLHRELSAGLVGLGLTYALMVSNYLNWMVRNLADMEIQLG 1325

  Fly   997 SVERVLEYRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPRE 1061
            :|:|:......|||...........|.|||.:|.|..:.||:||  |.....|||.:|.:|.|.:
Mouse  1326 AVKRIHTLLKTEAESYEGLLAPSLIPKNWPDQGKIQIQNLSVRY--DSSLKPVLKHVNALIAPGQ 1388

  Fly  1062 KIGIVGRTGAGKSSLINALFRL-SYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRC 1125
            ||||.||||:||||...|.||: ...||.::||..||..:.||.|||::|||.|:|||||||:|.
Mouse  1389 KIGICGRTGSGKSSFSLAFFRMVDMFEGRIIIDGIDIAKLPLHTLRSRLSIILQDPVLFSGTIRF 1453

  Fly  1126 NLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRIL 1190
            ||||.::.:|..||||||...||..|..||.||::::.|||.|:|.|||||.|||||.:|:..|.
Mouse  1454 NLDPEKKCSDSTLWEALEIAQLKLVVKALPGGLDAIITEGGENFSQGQRQLFCLARAFVRKTSIF 1518

  Fly  1191 VMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLT 1255
            :||||||::|..|:.::|..:...|.|.||:|||||::||:.:|.||||..|.::||..|.:||:
Mouse  1519 IMDEATASIDMATENILQKVVMTAFADRTVVTIAHRVHTILSADLVMVLKRGAILEFDKPEKLLS 1583

  Fly  1256 QSWSKVFYGMV 1266
            |. ..||...|
Mouse  1584 QK-DSVFASFV 1593

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	411/1365 (30%)
		ABC_membrane	92..362	CDD:294371	71/297 (24%)
		ABCC_MRP_domain1	412..611	CDD:213217	96/249 (39%)
		ABC_membrane	718..981	CDD:294371	67/297 (23%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	114/221 (52%)
Abcc8	XP_036008753.1	MRP_assoc_pro	224..1594	CDD:188098	415/1376 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841690
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2093
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.690