DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcb1a

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_035206.2	Gene:	Abcb1a / 18671	MGIID:	97570	Length:	1276	Species:	Mus musculus

Alignment Length:	1367	Identity:	306/1367 - (22%)
Similarity:	556/1367 - (40%)	Gaps:	258/1367 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 DKFFATWQSEVRSCGDSPKKEPSI-IRVILKVFGW--QLF-----LSGIVVGVLELGTRATLP-- 110
            ||.|:  :...:|..:..:|:|:: :..:.:..||  :|:     |:.|:.||       .||
Mouse    12 DKNFS--KMGKKSKKEKKEKKPAVSVLTMFRYAGWLDRLYMLVGTLAAIIHGV-------ALPLM 67

  Fly   111 -LILGALIAEFTRNGN----------------------------------GDGLWAQIYGLTLIL 140
             ||.|.:...|...||                                  |.|:....|     :
Mouse    68 MLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAYYYTGIGAGVLIVAY-----I 127

  Fly   141 SILFSVL----MFHPLMMGLMHLAMKMRVA---------VSTAIYRKALRLSRTALGDTTTGQVV 192
            .:.|..|    ..|.:.....|..|...:.         ::|.:.....:::. .:|| ..|...
Mouse   128 QVSFWCLAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTDDVSKINE-GIGD-KIGMFF 190

  Fly   193 NLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSR 257
            ..::...|.|   :|.|...|...|.:|..|..|....|:.:              ..||..|.:
Mouse   191 QAMATFFGGF---IIGFTRGWKLTLVILAISPVLGLSAGIWA--------------KILSSFTDK 238

  Fly   258 LRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSFEI 322
            ..|..|    :...:..|:::.|:.:..:..:|   :.:||. .:.:...:::...:....:..:
Mouse   239 ELHAYA----KAGAVAEEVLAAIRTVIAFGGQK---KELERY-NNNLEEAKRLGIKKAITANISM 295

  Fly   323 TLSRIAIFVSLLGFVLMGGELTAERAFSV----TAFYNILRRTVCKFFPSGMSQFAEMMVTLRRI 383
            ..:.:.|:.|.......|..|...:.:|:    |.|:::|   :..|.....|...|.....|
Mouse   296 GAAFLLIYASYALAFWYGTSLVISKEYSIGQVLTVFFSVL---IGAFSVGQASPNIEAFANAR-- 355

  Fly   384 KGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNH--DHVE------------------P 428
                     .|.|    :..|:.:.:|  .:.|| ::..|  |:::                  .
Mouse   356 ---------GAAY----EVFKIIDNKP--SIDSF-SKSGHKPDNIQGNLEFKNIHFSYPSRKEVQ 404

  Fly   429 VLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGD-------------ISYA 480
            :|:.:|:.:...|.||::|..|.|||:.:|.:........|.:.:.|.             |...
Mouse   405 ILKGLNLKVKSGQTVALVGNSGCGKSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVV 469

  Fly   481 SQEPWLFNASVRDNILFG---LPMDKHRYRNVIRNCALER---DF--ELLHGDRTFVGERGASLS 537
            ||||.||..::.:||.:|   :.||:      |.....|.   ||  :|.|...|.||||||.||
Mouse   470 SQEPVLFATTIAENIRYGREDVTMDE------IEKAVKEANAYDFIMKLPHQFDTLVGERGAQLS 528

  Fly   538 GGQRARISLARAVYRQADTYLLDDPLSAVDTH---VGRHLFEECMRGFLRDKLVILVTHQLQFLE 599
            |||:.||::|||:.|.....|||:..||:||.   |.:...::...|    :..|::.|:|..:.
Mouse   529 GGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQAALDKAREG----RTTIVIAHRLSTVR 589

  Fly   600 HADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQ----EMGD----SNQEQVNAEGDSRND 656
            :||:|...|.|.|...|.::|:::....:.||:.|:..    |:|:    |..|..|.:..|::.
Mouse   590 NADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTAGNEIELGNEACKSKDEIDNLDMSSKDS 654

  Fly   657 -KSTYSRQSSRVSRVSVTSVDS--STESILDNERQPAQ-------ESRSQGKIGLGIYGKYFSAG 711
             .|...|:|:|.|.......|.  ||:..||.:..||.       .|.......:||:....:.|
Mouse   655 GSSLIRRRSTRKSICGPHDQDRKLSTKEALDEDVPPASFWRILKLNSTEWPYFVVGIFCAIINGG 719

  Fly   712 SGWLMVILVAFFCLGTQILASGGDYFLSYWVKNNDSSSSTDIYIFSGINAALVIFALLRTLLFFS 776
               |.......|.....:..:||    ....:..:|:..:.:::..||.:.:..|  |:...|..
Mouse   720 ---LQPAFSVIFSKVVGVFTNGG----PPETQRQNSNLFSLLFLILGIISFITFF--LQGFTFGK 775

  Fly   777 MAMHSSTQLHNTMFQGVSRTALYFFH--ANPSGRILNRFAMDLGQVDEILPAVMLDCIQIFLTI- 838
            .....:.:|...:|:.:.|..:.:|.  .|.:|.:..|.|.|..||.....:.:....|....:
Mouse   776 AGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGATGSRLAVIFQNIANLG 840

  Fly   839 SGIIGVLCITNPWYL---------INTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFS- 893
            :|||  :.:...|.|         |..|...:....|....|...::|:....||...:.:..:
Mouse   841 TGII--ISLIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTV 903

  Fly   894 ATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCV---AYVISVTLMS 955
            .:|........|.||.|.....:..:..|..| .|| |..:|..|:....|.   ||:::..||:
Mouse   904 VSLTREQKFETMYAQSLQIPYRNAMKKAHVFG-ITF-SFTQAMMYFSYAACFRFGAYLVTQQLMT 966

  Fly   956 YFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDK- 1019
            :.|.         |::..|: :.|.:..|...|...:.:..:|......|.:|...|.:|...:
Mouse   967 FENV---------LLVFSAI-VFGAMAVGQVSSFAPDYAKATVSASHIIRIIEKTPEIDSYSTQG 1021

  Fly  1020 -KPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL 1083
             ||.|   .||.:....:...|...|... ||:.|:..:...:.:.:||.:|.|||:::..|.|.
Mouse  1022 LKPNM---LEGNVQFSGVVFNYPTRPSIP-VLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERF 1082

  Fly  1084 SYN--EGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYAD-------EKLW 1139
             |:  .||:.:|..:|..:.:..||:::.|:.|||:||.    |::.....|.|       |::.
Mouse  1083 -YDPMAGSVFLDGKEIKQLNVQWLRAQLGIVSQEPILFD----CSIAENIAYGDNSRVVSYEEIV 1142

  Fly  1140 EALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTD 1204
            .|.:|.::...:..||:...:.|.:.|:..|.||:|.:.:|||::|:..||::||||:.:|.:::
Mouse  1143 RAAKEANIHQFIDSLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESE 1207

  Fly  1205 ALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMV-LQ 1268
            .::|..:.:.....|.:.|||||:||.::|.::|:..|.:.|.|:..:||.|  ..:::.|| :|
Mouse  1208 KVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKEHGTHQQLLAQ--KGIYFSMVSVQ 1270

  Fly  1269 TG 1270
            .|
Mouse  1271 AG 1272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	301/1351 (22%)
		ABC_membrane	92..362	CDD:294371	52/328 (16%)
		ABCC_MRP_domain1	412..611	CDD:213217	69/242 (29%)
		ABC_membrane	718..981	CDD:294371	54/278 (19%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	66/229 (29%)
Abcb1a	NP_035206.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		4/15 (27%)
		PTZ00265	47..1263	CDD:240339	294/1319 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	646..681		9/34 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000