DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and mrp-3

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001359552.1	Gene:	mrp-3 / 181677	WormBaseID:	WBGene00003409	Length:	1505	Species:	Caenorhabditis elegans

Alignment Length:	1349	Identity:	453/1349 - (33%)
Similarity:	717/1349 - (53%)	Gaps:	138/1349 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSCGDSPK 74
            |.|:|...|..:..:...|:..|.::||...|::....:...|.|..::...|..:.....:...
Worm   194 PEENANFISRQLLLWFTQIISLGYERTLVADDVFEMDSQMDQEYLKARWKTEWLKQTEKAREKQV 258

  Fly    75 K-------------------------------------EPSIIRVILKVFGWQLFLSGIVVGVLE 102
            |                                     :||:|..:.::..|:: |.|..:..|.
Worm   259 KLDDKRERARTGSEKAPLLGTFNNYGAVNLDDKDRVIVQPSVIVTLWQIMKWEI-LGGSFIKFLS 322

  Fly   103 LGTRATLPLILGALIAEF-TRNG---NGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKM 163
            ...:...|..|..||... |.|.   ||.||     .:.|.|:.....|..:...:.:..:..|:
Worm   323 DLLQFANPTFLNYLILFIETPNAPLINGIGL-----AVGLFLAGQIKSLFMNTYFIAMTRVGAKI 382

  Fly   164 RVAVSTAIYRKALRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQ 228
            :..:|.|:|.|:|.||.||..:.|.|::||::|.|:.||..........|..|.:::|....|.|
Worm   383 QTMLSCAVYEKSLLLSNTARRERTVGEMVNILSIDVDRFRMITPQIQQYWSSPFQIIICMVLLSQ 447

  Fly   229 QIGVASLYGIVILLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFG 293
            .||||...|||:::..:||...:|.:|.|.:.:.....|:|:|::||:::||:|:|:..||....
Worm   448 TIGVAVWAGIVVMISIVPINICVSMITKRWQLRLMKYKDERIRLINEVLNGIKVVKLSAWETAME 512

  Fly   294 RLIERLRRSEMSSIRKVNYIRGTLLSFEITLSRIA-IFVSLLG---FVLMGGE--LTAERAFSVT 352
            ..|||:|..|:..|::    ...|.:|...|:..| :||:|..   |||:..:  ||...||...
Worm   513 ETIERVRDKELKMIKQ----SALLKTFADCLNVGAPVFVALSSFTVFVLIDPKNVLTPNIAFVSL 573

  Fly   353 AFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGE---PLVKL 414
            :.:|:||..: ......::|..:::|:.:|::.|:...|.:...:     :|...||   ..|::
Worm   574 SLFNLLRGPL-MMAAELVAQTVQLVVSNKRVRTFLCEKEVDTAAI-----DKEIRGELYTNTVEI 632

  Fly   415 QSFQARWNHDHVEP-VLENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDIS 478
            .|....|  |..|. :|.:|.......:||.|:|.||||||||:.|.|||:....|.:.|:|.::
Worm   633 HSGSFAW--DSAEARILSDIEFLAGSKELVTVVGSVGSGKSSLLLAALGEMEKVCGYVGVRGSVA 695

  Fly   479 YASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCALERDF-ELLHGDRTFVGERGASLSGGQRA 542
            |.||:||:.|.|::.|:|....::...|:.||.:|||:.|. :|..||.|.:||:|.:|||||:|
Worm   696 YLSQQPWILNQSLKKNVLMQADLNDVLYKKVIESCALKEDLKQLPDGDDTEIGEKGINLSGGQKA 760

  Fly   543 RISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIV 605
            ||:||||||:..|.|.|||||||||.|||:|:|:..:  .|.|.....||||:...||:.:..|:
Worm   761 RIALARAVYQSKDVYFLDDPLSAVDAHVGKHIFDNVIGPNGMLSHTTRILVTNCTSFLQESGKII 825

  Fly   606 IMDKGKISAVGTYEEMLK--SGQDFGKLLATEAQEMGDSNQEQVNAEGDS---RNDKSTYSRQSS 665
            :|..|:|...|||.|:|.  ..:::.:.:..|..:..:|:.|:...|.:|   ....::.||. |
Worm   826 VMKDGRIKHCGTYNELLTDVEAREYLQEVDNEYAQAQESSGEESGGEENSDILPGSIASGSRM-S 889

  Fly   666 RVSRVSVTSVDSSTESILDNERQPA---QESRSQGKIGLGIYGKYFSAGSG--------WLMVIL 719
            |:||:|..|...|..||::.::..|   :|..:.|::..|:|..||.| .|        .:.|:|
Worm   890 RLSRLSKISRKKSKSSIVEKKKPDALITKEEAAIGRVNPGVYLLYFKA-MGIVTYVLPYAIAVVL 953

  Fly   720 VAFFCLGTQILASGGDYFLSYWVKNNDSSSSTD-------IYIFSGINAALVIFALLRTLLFFSM 777
            ...|.||..:       :|:.|...|...:..|       :.:::|.....|||      ||||:
Worm   954 NVSFALGRSL-------WLTAWSDANIDINHPDTMSVGARLGVYAGFGITEVIF------LFFSL 1005

  Fly   778 AM------HSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVD-------EILPAVML 829
            .:      .:|..||..:...|.|..|.:|...|.|||:||.|.|:..||       ..|...::
Worm  1006 VLLLIGGVAASKNLHKPLLHNVLRNPLSYFDITPIGRIINRLAKDMEVVDLRLSSSFRFLVMALI 1070

  Fly   830 DCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSHFSA 894
            :.:|..|.:|       .|.|.::...|.:|:.:.|:..:.:.::|.|:|:.::.|||::|:||.
Worm  1071 NMVQTVLIVS-------YTTPLFIAIIIPVFIIYFFVLKYSIKSTRQLQRIASLTRSPIFSNFSE 1128

  Fly   895 TLNGLSTIRAMEAQDLLTKEYDNYQDIH-SSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMSYFN 958
            ||.|:||:||.:..|...:..|.:.:.| ...||:.:: ||.....|:|.....:.|..:::...
Worm  1129 TLQGISTVRAFQWSDEFVRRNDEHLNTHVKCSYYSQMA-NRWLSIRLELLGNIVIFSAAILAIIG 1192

  Fly   959 PPVD-NPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPP 1022
            .... ..|.:||.::.::::|..:...:||..|:|.::.||||:.||...::|.|:.. |:...|
Worm  1193 KESGITAGMLGLSVSYSLNITFMLNMFVRQINEVETNVVSVERIDEYSKTKSEAEWRL-DNNNLP 1256

  Fly  1023 MNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRL-SYN 1086
            .|||..|.::.|..|.||..:  .|.|||.::..|:|.:|:|:.||||||||||..||||: ...
Worm  1257 SNWPTGGAVNIEDYSCRYRDE--LDLVLKQISLNILPGQKVGVCGRTGAGKSSLALALFRIVEAA 1319

  Fly  1087 EGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEV 1151
            :|::.||.|....|||||||.|::|||||.|||:.|||.|:||..|:.|::||.|||..:||..|
Worm  1320 DGNISIDQTITSHIGLHDLREKLTIIPQENVLFANTLRFNIDPKGQFTDQQLWLALENSNLKAHV 1384

  Fly  1152 SELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFR 1216
            ..||:.|||.|||||.|:|||||||:||.||:||::::||:|||||.:|.:||.::|:|||.||.
Worm  1385 ELLPHKLESPVAEGGENFSVGQRQLLCLTRALLRKSKVLVLDEATAGIDNRTDTMVQATIREKFA 1449

  Fly  1217 DCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGM 1265
            |.|::||||||:||||.||::|:|||.:||.|.|.|||....|: |||:
Worm  1450 DSTIITIAHRLHTIIDYDRIIVMDAGRIVEDGIPGELLKNRNSQ-FYGL 1497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	449/1339 (34%)
		ABC_membrane	92..362	CDD:294371	85/279 (30%)
		ABCC_MRP_domain1	412..611	CDD:213217	89/202 (44%)
		ABC_membrane	718..981	CDD:294371	72/284 (25%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	124/221 (56%)
mrp-3	NP_001359552.1	MRP_assoc_pro	25..1501	CDD:188098	453/1349 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	82	1.000	Domainoid score	I5384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.720