Protein Alignment CG9270 and mrp-4

DIOPT Version :9

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: NP_509658.1
• Gene: mrp-4 / 181202
• WormBaseID: WBGene00003410
• Length: 1573
• Species: Caenorhabditis elegans
• Alignment Length: 1373
• Identity: 475/1373 - (34%)
• Similarity: 726/1373 - (52%)
• Gaps: 175/1373 - (12%)

  Fly    32 GRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRS---------------------------- 68
            |.||.||.:|||:..:...:..|..|::..|..:.:.
 Worm   240 GVKKPLEVSDLYSLNEADTSNLLVPKWYNLWDKQSKKFEETAARRRIGSNASRTNRRRTSSNDTT 304

  Fly    69 ---------------CGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIA 118
                           .|.|.:|.||||..:..:|.|.: ::.:.|.:|........||:|.:||
 Worm   305 PLLNDQSTDDYGSVPAGQSTQKMPSIIWTLFLMFKWDV-ITAMFVKLLSDVLLFCNPLLLKSLI- 367

  Fly   119 EFTRNGNGDGLWAQIYGLTLILSILF-----SVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRL 178
            .||...... :|   .|:.|..::.|     |:|:.|...: :..:..:::..::.|:|||.|||
 Worm   368 RFTEELERP-MW---QGVVLAFTMFFSAELSSILLSHYFYL-MYRVGTRVQTCLTAAVYRKTLRL 427

  Fly   179 SRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLL 243
            |..|..:.|.|::|||::.|:.||.:........|..|.::.::.:.|:||:||:...|:.:::|
 Worm   428 SNAARREKTVGEIVNLMAIDVDRFQQITPQTMQYWSNPFQIGLALFLLFQQLGVSVFSGVAVMVL 492

  Fly   244 FLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIR 308
            ..||...::.:..:.:.......|:|.:|:||:::||:|||:|.||.|..::||.||..|:..|:
 Worm   493 LFPINFVITMIIRKWQIAQMYYKDERTKMVNEVLNGIKVIKLYAWEPPMEQVIEDLREQELGLIK 557

  Fly   309 KVNYIR------GTLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFP 367
            |..::|      .|...|.:.||..|.|:    ::.....||.|.||.....:|.||
 Worm   558 KAAFLRTFSDMLNTASPFLVALSTFATFI----YIDPKNVLTPEIAFVSLTLFNQLR-------- 610

  Fly   368 SGMSQFAEM-------MVTLRRIKGFMMRSE--TEALYLKGGQTNKLFEGEPLVKLQSFQARWNH 423
            |.|||.||:       :|:.||:|.|::..|  .||:      .::..:...::.|:.....|..
 Worm   611 SPMSQVAELITQTVQVVVSNRRLKEFLVSEELNVEAI------DHRARDNNDVICLKEACLSWES 669

  Fly   424 DHVEPV--LENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWL 486
            ...:||  |.||:.|::..|||.::|.||:||||::||::||:...||.:.:.|.:.|..|:||:
 Worm   670 AEHQPVPTLTNISFSVNRGQLVTIVGRVGAGKSSMLQALMGEMEKLSGSISMHGRLCYVPQQPWM 734

  Fly   487 FNASVRDNILFGLPMDKHRYRNVIRNCALERDFELLH-GDRTFVGERGASLSGGQRARISLARAV 550
            .|.::|.||.||...|::.|..|:..|||.||.::|. ||.|.:||:|.:|||||:|||||||||
 Worm   735 QNNTLRQNITFGKQFDEYFYSRVLDACALYRDLQILPLGDNTEIGEKGINLSGGQKARISLARAV 799

  Fly   551 YRQADTYLLDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKIS 613
            |:..|.||||||:||||.|||..||...:  .|.||:|..||||::|.|||.:|||::|::|||.
 Worm   800 YQNHDIYLLDDPMSAVDAHVGSQLFGSVIGPEGMLRNKTRILVTNELSFLEKSDLIIVMNEGKIE 864

  Fly   614 AVGTYEEMLKSGQDFGKLLATEAQEMGDSNQEQVNAEGDSRNDK--------------------- 657
            ..|.|:::::.|. |.:||....:|..:..:.:.:|:.|..|.:
 Worm   865 YSGKYDDLMQQGA-FEQLLIECEKEERERREAEASADEDDENSEPGGIMIGGDSDFEYDDDVMAS 928

  Fly   658 ------------STYS-------------RQSSRVSRV-----SVTSVDSSTESILDNERQPAQE 692
                        ||.|             :|..|:|..     |:||..:.|..:...||.
 Worm   929 PIIDHVLGTSHMSTVSGIINRRRISTSTHKQRRRLSTTKSHTHSITSASTQTRQLTGTERV---- 989

  Fly   693 SRSQGKIGLGIYGKYFSAGSGWLMVILVAFFCLG---TQILASGGDYFLSYWVKNNDSSSSTD-- 752
              ..|::.:..|.|||.| .|..:.:|   |.||   :.|.:.|.:.:|:.|..:|.:.|.::
 Worm   990 --ETGRVKMDTYYKYFGA-MGMSIAVL---FVLGMTTSTIFSMGRNLWLTDWSNDNAARSGSNTT 1048

  Fly   753 ---------IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGR 808
                     :|...|.:..:::|..:.:||:..::  :|..||..:.:.:.|..:.|:...|.||
 Worm  1049 GQPIAIRLGVYAGLGFSEIILLFIGMLSLLYGGVS--ASRNLHAPLMRNLFRVPMAFYDTTPFGR 1111

  Fly   809 ILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLST 873
            ||||...|:..||.:||..:....|..|.:...:.::.|:.|.:.|..|.:.:.:..:..:|::|
 Worm  1112 ILNRIGKDIETVDVLLPFNVQFFAQCLLQVVSTLIIIMISTPVFGIVIIPLSVMYLMVMRYYIAT 1176

  Fly   874 SRDLKRLEAIARSPMYSHFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGY 938
            ||.|||||:|.|||:|||.|.::.|.:||||....|...|..:...|.|....|.....||....
 Worm  1177 SRQLKRLESITRSPIYSHLSESIQGSATIRAYHLVDRFCKLSETKVDSHVQCRYLNYVANRWLSV 1241

  Fly   939 YLDLFCVAYVISVTLMSYFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLE 1003
            .|:......|:...|.:.........|.|||.::.|:::|..:.:.:||..:||.::.|||||.|
 Worm  1242 RLEFIGNCIVLFSALFAALTRTTTTSGVIGLSVSYALNITTVLNFAVRQITKLETNIVSVERVKE 1306

  Fly  1004 YRHLEAEGEFESPDDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGR 1068
            |...|.|.|::|...|:||.|||.||.|.....|.||.|.  .:.|:|.||..|.|.||:|||||
 Worm  1307 YAETETEAEWKSEPGKEPPQNWPSEGRIVMNNYSARYRPG--LNLVVKQLNVEIKPHEKVGIVGR 1369

  Fly  1069 TGAGKSSLINALFR-LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQ 1132
            |||||||:..:||| :...||.:|:|..::..||||||||.::||||:|||||||||.|||||..
 Worm  1370 TGAGKSSVTLSLFRIIEAAEGQIVVDGINLAEIGLHDLRSNLTIIPQDPVLFSGTLRFNLDPFNH 1434

  Fly  1133 YADEKLWEALEEVHLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATA 1197
            |:|..:|:.||..:||:..:.....|..::.|||.|.|||||||||||||:||:.|:|::|||||
 Worm  1435 YSDGDIWKTLEMANLKEFATAHNEQLNYIITEGGDNISVGQRQLVCLARALLRKTRVLILDEATA 1499

  Fly  1198 NVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVF 1262
            .||..||||||.|||.:|.:.||||||||||||:|.||::||:.|.:.||.||..||:...|: |
 Worm  1500 AVDVSTDALIQKTIREEFANATVLTIAHRLNTIMDYDRIIVLNDGKVGEFDSPANLLSNRNSE-F 1563

  Fly  1263 YGMVLQTG 1270
            |.|..:.|
 Worm  1564 YSMAKRAG 1571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	470/1358 (35%)
		ABC_membrane	92..362	CDD:294371	80/280 (29%)
		ABCC_MRP_domain1	412..611	CDD:213217	97/203 (48%)
		ABC_membrane	718..981	CDD:294371	76/276 (28%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	125/221 (57%)
mrp-4	NP_509658.1	MRP_assoc_pro	17..1572	CDD:188098	475/1373 (35%)
		ABC_membrane	346..613	CDD:294371	81/284 (29%)
		ABCC_MRP_domain1	658..862	CDD:213217	97/203 (48%)
		ABC_membrane	1012..1259	CDD:294371	70/251 (28%)
		ABCC_MRP_domain2	1332..1552	CDD:213211	125/221 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.730