DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and mrp-1

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_001024719.2	Gene:	mrp-1 / 180409	WormBaseID:	WBGene00003407	Length:	1534	Species:	Caenorhabditis elegans

Alignment Length:	1355	Identity:	480/1355 - (35%)
Similarity:	732/1355 - (54%)	Gaps:	134/1355 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEVRSC----- 69
            |..:|...:.|.|.:...:.:.|.||:||..||::..:..|||.:...|......||...
Worm   208 PEYTASFLNQLTFQWFSGLAYLGNKKSLEKEDLWDLNERDKAENIIPSFIENLIPEVEGYRRKIK 272

  Fly    70 ----GDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGLW 130
                ...||..|||:..|.|.:.:.|...|....:.:| .:...|.:|..||: |..:.| ..:|
Worm   273 KNPEAAIPKNHPSILIPIFKTYKFTLLAGGCYKLMFDL-LQFVAPELLRQLIS-FIEDKN-QPMW 334

  Fly   131 AQI-YGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQVVNL 194
            ..: ..|.:.||.|...::.|.....:..|.|.:|..:::|:|.|.|.||..|....|||.:|||
Worm   335 IGVSIALLMFLSSLLQSMILHQYFHEMFRLGMNIRSVLTSAVYTKTLNLSNEARKGKTTGAIVNL 399

  Fly   195 ISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLTSRLR 259
            :|.|:.|...........|..||::|:|.|||::.:||:.|.|.|||:|.:|..:|:|......:
Worm   400 MSVDIQRIQDMTTFIMLFWSAPLQILLSLYFLWKLLGVSVLAGFVILILLIPFNSFISVKMRNCQ 464

  Fly   260 HQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIR-GTLLSFEIT 323
            .:.....|:|::||:||::|::|:|:|:|||...:::..:|..|:..::|::|:. .|.||:...
Worm   465 MEQMKFKDERIKMMSEILNGMKVLKLYSWEKSMEKMVLEVREKEIRVLKKLSYLNAATTLSWACA 529

  Fly   324 LSRIAIFVSLLGFVLMGGE---LTAERAFSVTAFYNILRRTVCKFFPSGM-----SQFAEMMVTL 380
            ...:|:....| :||...|   ||.:..|...|.:||||      ||..:     ||..:...:.
Worm   530 PFLVAVLTFGL-YVLWDPENNVLTPQITFVALALFNILR------FPLAVFAMVFSQAVQCSASN 587

  Fly   381 RRIKGFMMRSETEALYLKGGQTNKLFEG-EPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVA 444
            .|:|.|....|...      ||:..:.| :..:|:......|.....:..|.:|..::...||||
Worm   588 TRLKEFFAAEEMSP------QTSIAYGGTDSAIKMDGGSFAWGSKEEDRKLHDITFNIKRGQLVA 646

  Fly   445 VIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNV 509
            ::|.||||||||:.|:|||:...||.::|.|.::|..|..|:.|.|:|:||||..|.|...|:||
Worm   647 IVGRVGSGKSSLLHALLGEMNKLSGSVQVNGSVAYVPQLAWIQNLSLRNNILFNRPYDAKLYQNV 711

  Fly   510 IRNCALERDFELLHG-DRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRH 573
            |.||||.:|.|.|.. |||.:||:|.:|||||:.|:|||||||:.|:..||||||||||:|||:|
Worm   712 IENCALVQDLESLPAEDRTEIGEKGINLSGGQKQRVSLARAVYQNAEIVLLDDPLSAVDSHVGKH 776

  Fly   574 LFEECM---RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFG----KL 631
            :||..:   .|.|..|..:|:||.|.:|:|.|.::::....||.:|||:|::.|...|.    :.
Worm   777 IFENVISTATGCLGTKTRVLLTHGLTYLKHCDQVIVLKDETISEMGTYQELMNSNGAFSEFLEEF 841

  Fly   632 LATEAQEMG-------DSN--------------------QEQVNAEGDSRNDKSTYSRQSS--RV 667
            |..|::..|       ||.                    |.|::.|.:..:||:....::.  :.
Worm   842 LLEESKHKGRSVSFGEDSKEVNELLRDLDQVSPAIRQRIQSQMSQEIEKTDDKNAEIIRNGLHKD 906

  Fly   668 SRVSVTSVDSS--TESIL------DNERQPAQESRSQ---------GKIGLGIYGKYFSAGSGWL 715
            .:.:.:|:..|  .||:|      :...:|.:::::|         ||:...:|..||.|..  :
Worm   907 EQTAHSSIGKSEEKESLLGAISPKEKTPEPPKQTKTQLIEKEAVETGKVKFEVYMSYFRAIG--I 969

  Fly   716 MVILVAFFC-LGTQILASGGDYFLSYW--------VKNNDSSSSTD----IYIFSGIN------A 761
            .:.||.|.. :.:.:|....:.:|:.|        :..|.|||.|.    ||...|:.      |
Worm   970 KIALVFFLVYVASSMLGVFSNLYLARWSDDAKEIALSGNGSSSETQIRLGIYAVLGMGQATSVCA 1034

  Fly   762 ALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPA 826
            |.:|.||       .|.. :|..||.|:.:.:.|:.:.||...|.|||||||..|:..||..:|.
Worm  1035 ASIIMAL-------GMVC-ASRLLHATLLENIMRSPMAFFDVTPLGRILNRFGKDVDGVDTDIPR 1091

  Fly   827 VMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSH 891
            .|...|:..::...||.::....|..:...:.:|:.:..:..||:||||.|||||:.:|||:|||
Worm  1092 TMSMFIRTAVSSIEIIAIILWATPLAISLLLPLFIVYFVVLRFYVSTSRQLKRLESASRSPIYSH 1156

  Fly   892 FSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVI-SVTLMS 955
            |..::.|.|:|||....|...:|..:..|.:.:.||..:..||.....|::.....|: |.....
Worm  1157 FQESIQGASSIRAYGVVDKFIRESQHRVDENLATYYPSIVANRWLAVRLEMVGNLIVLSSAGAAV 1221

  Fly   956 YFNPPVDNP----GQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESP 1016
            ||.   |:|    |.:||.::.|:::|.|:.|.:|.::|||.::.:|||:.||.....||   :.
Worm  1222 YFR---DSPGLSAGLVGLSVSYALNITQTLNWAVRMTSELETNIVAVERINEYTITPTEG---NN 1280

  Fly  1017 DDKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALF 1081
            .....|.:||:.|.||.:..|:||.|.  .|.||..:...|.|.||||||||||||||||..|||
Worm  1281 SQSLAPKSWPENGEISIKNFSVRYRPG--LDLVLHGVTAHISPCEKIGIVGRTGAGKSSLTLALF 1343

  Fly  1082 RLSYNEGSLV-IDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEV 1145
            |:...:|..: ||.|:|..:.|..|||:::|:||:|||||||:|.|||||..::|:::||||...
Worm  1344 RIIEADGGCIEIDGTNIADLLLEQLRSRLTIVPQDPVLFSGTMRMNLDPFFAFSDDQIWEALRNA 1408

  Fly  1146 HLKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQST 1210
            ||...|..|..||...::|||.|.|||||||:|||||:||:.::||:|||.|.||.:||:|:|.|
Worm  1409 HLDSFVKSLQEGLHHHISEGGENLSVGQRQLICLARALLRKTKVLVLDEAAAAVDVETDSLLQKT 1473

  Fly  1211 IRRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGM 1265
            ||.:|:|||||||||||||::||||::|||.|.:.||.:|.:||:.. ..:||.|
Worm  1474 IREQFKDCTVLTIAHRLNTVMDSDRLLVLDKGCVAEFDTPKKLLSNP-DGIFYSM 1527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	477/1345 (35%)
		ABC_membrane	92..362	CDD:294371	85/274 (31%)
		ABCC_MRP_domain1	412..611	CDD:213217	94/202 (47%)
		ABC_membrane	718..981	CDD:294371	87/286 (30%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	125/221 (57%)
mrp-1	NP_001024719.2	MRP_assoc_pro	23..1531	CDD:188098	480/1355 (35%)
		ABC_membrane	309..570	CDD:294371	85/270 (31%)
		ABCC_MRP_domain1	614..815	CDD:213217	94/200 (47%)
		ABC_membrane	976..1248	CDD:279056	85/282 (30%)
		ABCC_MRP_domain2	1293..1513	CDD:213211	125/221 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.830