DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG9270 and cft-1

DIOPT Version :9

Sequence 1:NP_995741.2 Gene:CG9270 / 35366 FlyBaseID:FBgn0032908 Length:1292 Species:Drosophila melanogaster
Sequence 2:NP_504463.1 Gene:cft-1 / 178939 WormBaseID:WBGene00000477 Length:1247 Species:Caenorhabditis elegans


Alignment Length:1325 Identity:330/1325 - (24%)
Similarity:598/1325 - (45%) Gaps:174/1325 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 AKKLQT---NPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQS 64
            |:::|.   |.:..:...|.|:......:|.|.|..|:...|| ..|:|.:........| .|:.
 Worm    13 ARQIQNETENEQAKSSFASKLLELPVSKLLQKCRSSTITVDDL-PILEEKQCSNRVMSGF-KWKK 75

  Fly    65 EVRSCGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALI--AEFTRNGNGD 127
            .|            |..:::|.  |:.|.......:..:.......|:|..||  ||.:      
 Worm    76 RV------------IFSILMKF--WKSFAGAFAFRMCAIFADYASILLLKYLIDSAEIS------ 120

  Fly   128 GLWAQIYGLTLILSILFSVLMFHPLMMGLMHL------AMKMRVAVSTAIYRKALRLSRTALGDT 186
               |.::...:|..::...:....|::| :|.      :::|...::..|.:|||.|: :...|.
 Worm   121 ---ATLFNFFIIAVLILFFMQLKSLLLG-VHTYLVGEDSVEMVTVLNNIIVKKALHLT-SENTDW 180

  Fly   187 TTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFL 251
            ...::..|::.........|.:.|......:||.|:.:::::.:|..::..::|:.|...:...:
 Worm   181 NRSKISKLLTTHSEAVSNGLAYVHHSCSALIELTIALFWIWETLGTRTIIVVLIVALVYAVFNII 245

  Fly   252 SRLTSR--LRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIR 314
            .....:  |:.|...| |:||.....:::.::.|||::||..|.:.::.:|..|:|..||...|.
 Worm   246 DSYVYKKSLKVQLKCR-DERVEFEKTVLNSMETIKMFSWEPHFWKKLKSMRGKELSVFRKTLSIN 309

  Fly   315 GTLLSFEITLSRIAIFVSLLGFVLMG-----GELTAERAFSVTAFYNILRRTVCKFFPSGMSQFA 374
            ..:.|..:|...:..|||   |.:.|     ..|..|.||.:.|.:|.:||.:....|| :....
 Worm   310 SFMHSLNVTSPFVITFVS---FAVYGLQYEISALRFEDAFVLIAIFNYMRRPLHVIIPS-LEIVD 370

  Fly   375 EMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSP 439
            :.:.:...|..|::..::..:..|......:   ||.:.::...|.::.:..:..|.::.:.:..
 Worm   371 KALHSATIINQFLIVKQSPKINTKTAPQPPV---EPDLDIKILNANFSWNGKDDTLNDVCVHVKK 432

  Fly   440 PQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKH 504
            .:..|.||....|||||:.:|.|||....|.:.|...||:|...|::|:.|:::|||||....|.
 Worm   433 GEKHAFIGFPLCGKSSLLFSITGELKMTKGNMWVSKGISFAPASPYIFSQSLKENILFGNDYVKS 497

  Fly   505 RYRNVIRNCALERD-FELLHGDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDT 568
            :|..||..|.|::| |.|...:.|.:|::|..|:..|:|:|||||.:|..||.|.||.....:|.
 Worm   498 KYDKVIMACDLKKDIFSLPRCEATVLGDKGYVLTSTQKAQISLARCLYEDADIYALDKAFGPMDR 562

  Fly   569 HVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKL 631
            .....:|...:  .|:||||.|||.|:.::.::...::.::..|||...|:|:::|:..:....|
 Worm   563 TTSNKIFTRVLGENGYLRDKTVILATNNIELIKTFTMVHVLKNGKIETSGSYDQILECSEIMSDL 627

  Fly   632 LATEAQEMGDSNQEQVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQ-------- 688
            |          ||        ||.||....:.|...........|   :.:|...::        
 Worm   628 L----------NQ--------SRIDKIIEEKYSDEKPPRKTVMFD---DKVLKKRKKKQSMEDTA 671

  Fly   689 PAQESRSQGKIGLGIYGKYFSAGS----GWLMVILVAFFCLGTQILASGGDYFLSYW---VKNND 746
            |..|:||       :|..||.:||    .:.:|:|:..|..  |.||.   ::||:|   |....
 Worm   672 PVFENRS-------VYPFYFRSGSFIFTAFYIVLLICRFVF--QALAF---FWLSFWLDPVWKKV 724

  Fly   747 SSSSTDIYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRT--ALYFFHANPSGR- 808
            ...:...|:|....:...|.|::.|:|.::..:.::.|....::|.::..  |:.....:|:.: 
 Worm   725 ECENCPQYVFIQTMSFFAISAIISTMLSYTFFVLTNVQTSRKLYQHITSAIFAVPMIFLSPTNKE 789

  Fly   809 -ILNRFAMDLGQVDEILPAVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAF------HFL 866
             ::|....||..||...|.......:..|.|..|..::|:..|.:.| .:..||.|      :||
 Worm   790 SLMNMITSDLDIVDTQFPLFFKFSFECTLHILMIFAIVCVNVPVFAI-FVVAFLIFLVGLLRYFL 853

  Fly   867 RTFY-LSTSRDLKR-------LEAIARSPMYSHFSATLNGL--STIRAMEAQDLLTKEYDNYQDI 921
            ...: :|:..:.||       :|......|...|..|...|  :::.|    |:||:       .
 Worm   854 PALHKISSLEEQKRDLFLCGSIEDFEARIMVRTFGKTRQTLAKTSVNA----DILTR-------C 907

  Fly   922 HSSGYYT--FLSTNRAFGYYLDLFCVAYVISVTLMSYFNPPVDNPG--QIGLVITQAMSMTGTVQ 982
            ..:.|.|  ::|....|...| :.|:.:.|:...:.     ||..|  |..|.:...:.::..|.
 Worm   908 RMARYSTLRWISLRTEFISNL-MICMCFFIASICLK-----VDYIGNAQFALSVASILCISELVS 966

  Fly   983 WGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKKPPM--------NWPQEGLISAEQLSLR 1039
            ..:|.:..||:....|:|:...|        |.|   |.||        :||.:|.|..:.|::.
 Worm   967 TFIRTTCILESLTPHVQRISNVR--------EYP---KEPMIDKCTIRDSWPDDGKIEIKNLNVF 1020

  Fly  1040 YNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSY--NEGSLVIDNTDILGIGL 1102
            .|   |...|:|.::.:|..|||:||:|:.|:|||.|...|..:|.  .|..:|:|:.||..:.:
 Worm  1021 AN---KYRHVIKDVSLVIEEREKLGIIGKVGSGKSQLAKTLVMMSSADKESHIVVDDLDIFEMSV 1082

  Fly  1103 HDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDEVSELPNGLESVVA-EGG 1166
            ..|||:|::|||:..:||.|||.|:||..|:||..:|.|:|...|::.|..||:||..:|: |..
 Worm  1083 KTLRSRITVIPQKAKIFSDTLRSNIDPCCQFADSDIWLAIEACQLREYVKSLPDGLHQMVSPEKM 1147

  Fly  1167 SNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKFRDCTVLTIAHRLNTII 1231
            ||   .|:..|.:.||:|:..:|.|:|::|..:.....:|:...||...:..|.:.|....:.:.
 Worm  1148 SN---EQKCQVNVCRALLKGGQIFVIDQSTKMMKEPIKSLVNEAIRNSLKQSTTIWIGEDFSDVE 1209

  Fly  1232 DSDRVMVLDAGTLVEFGSPFELLTQ 1256
            ..|||:|::.|.::...:|..|:::
 Worm  1210 HCDRVVVIENGVILTTDTPQNLISE 1234

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG9270NP_995741.2 CFTR_protein 6..1257 CDD:273530 329/1322 (25%)
ABC_membrane 92..362 CDD:294371 61/284 (21%)
ABCC_MRP_domain1 412..611 CDD:213217 64/201 (32%)
ABC_membrane 718..981 CDD:294371 60/289 (21%)
ABCC_MRP_domain2 1029..1250 CDD:213211 76/223 (34%)
cft-1NP_504463.1 MdlB 76..631 CDD:224055 146/605 (24%)
ABC_membrane 93..359 CDD:294371 60/280 (21%)
P-loop_NTPase 407..607 CDD:304359 64/199 (32%)
ABC_membrane 696..938 CDD:294371 56/259 (22%)
P-loop_NTPase 1010..1228 CDD:304359 76/223 (34%)
EcfA2 1012..1234 CDD:224047 77/227 (34%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160157421
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E2759_KOG0054
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2093
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D138195at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24223
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
76.800

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