Protein Alignment CG9270 and Abcc4

DIOPT Version :9

• Sequence 1: NP_995741.2
• Gene: CG9270 / 35366
• FlyBaseID: FBgn0032908
• Length: 1292
• Species: Drosophila melanogaster
• Sequence 2: XP_038948894.1
• Gene: Abcc4 / 170924
• RGDID: 620266
• Length: 1382
• Species: Rattus norvegicus
• Alignment Length: 1373
• Identity: 583/1373 - (42%)
• Similarity: 840/1373 - (61%)
• Gaps: 116/1373 - (8%)

  Fly     5 KLQTNPRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQSEV-RS 68
            :::.||.:.|.:.|.|.|.:..|:...|.|:.||..|:::.|.|.:::.||::....|..|| |:
  Rat     7 EVKPNPLQDANLCSRLFFWWLNPLFKAGHKRRLEEDDMFSVLPEDRSKHLGEELQGYWDKEVLRA 71

  Fly    69 CGDSPKKEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLPLILGALIAEFTRNGNGDGL---- 129
            ..|:  ::||:.:.|:|.: |:.:|...:..::|..||...|:.||.:|..|.:..:.|..
  Rat    72 KKDA--RKPSLTKAIVKCY-WKSYLILGIFTLIEETTRVVQPIFLGKIIDYFEKYDSDDSAALHT 133

  Fly   130 ---WAQIYGL-TLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKALRLSRTALGDTTTGQ 190
               :|.:..| ||||:||..:..:|....|     |::|||:...|||||||||.:|:|.|||||
  Rat   134 AYGYAAVLSLCTLILAILHHLYFYHVQCAG-----MRIRVAMCHMIYRKALRLSNSAMGKTTTGQ 193

  Fly   191 VVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVILLLFLPIQTFLSRLT 255
            :|||:|||:.:||:..|..||||.|||:.:..:..|:.:||::.|.|:.||::.||:|:.:.:|.
  Rat   194 IVNLLSNDVNKFDQVTIFLHFLWAGPLQAIGVTILLWVEIGISCLAGLAILVILLPLQSCIGKLF 258

  Fly   256 SRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMSSIRKVNYIRGTLLSF 320
            |.||.:||..||.|:|.|||:|:|:::||||.|||.|..||..||:.|:|.|...:|:||..::.
  Rat   259 SSLRSKTAAFTDARIRTMNEVITGMRIIKMYAWEKSFADLITNLRKKEISKILGSSYLRGMNMAS 323

  Fly   321 EITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCKFFPSGMSQFAEMMVTLRRIKG 385
            ....:::.:||:...:||:|.::||...|.....|..:|.||..||||.:.:.:|.:|::||||.
  Rat   324 FFIANKVILFVTFTTYVLLGNKITASHVFVAMTLYGAVRLTVTLFFPSAIERVSEAVVSVRRIKN 388

  Fly   386 FMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPVLENINISLSPPQLVAVIGPVG 450
            |::..|     |...:..:..:|:.:|.:|.|.|.|:.....|.|:.::.:..|.:|:||:||||
  Rat   389 FLLLDE-----LPERKAQEPSDGKAIVHVQDFTAFWDKALDTPTLQGLSFTARPGELLAVVGPVG 448

  Fly   451 SGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDNILFGLPMDKHRYRNVIRNCAL 515
            :|||||:.|:|||||..||.:.|.|.|:|.||:||:|:.:||.|||||...:|.||..||:.|||
  Rat   449 AGKSSLLSAVLGELPPTSGLVSVHGRIAYVSQQPWVFSGTVRSNILFGRKYEKERYEKVIKACAL 513

  Fly   516 ERDFELLH-GDRTFVGERGASLSGGQRARISLARAVYRQADTYLLDDPLSAVDTHVGRHLFEECM 579
            ::|.:||. ||.|.:|:|||:|||||:||::||||||:.||.|||||||||||..||:|||:.|:
  Rat   514 KKDLQLLEDGDLTVIGDRGATLSGGQKARVNLARAVYQDADIYLLDDPLSAVDAEVGKHLFQLCI 578

  Fly   580 RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEMLKSGQDFGKLLATEAQEMGDSNQ 644
            ...|.:|:.||||||||:|:.|..|:|:..|::...|||.|.||||.|||.||..|.:|   :..
  Rat   579 CQTLHEKITILVTHQLQYLKAASHILILKDGEMVQKGTYTEFLKSGVDFGSLLKKENEE---AEP 640

  Fly   645 EQVNAEGDSRN----DKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPA---QESRSQGKIGLG 702
            ..|......||    :.|.:|:||||      .|:........|.|...|   :||||:|:||..
  Rat   641 SPVPGTPTLRNRTFSEASIWSQQSSR------PSLKDGVPDAQDAENTQAAQPEESRSEGRIGFK 699

  Fly   703 IYGKYFSAGSGWLMVILVAFFCLGTQILASGGDYFLSYWVKN----NDSSSSTD----------- 752
            .|..|||||:.|..:|.:....|..|:.....|::||:|...    ||:.::..
  Rat   700 AYKNYFSAGASWFFIIFLVLLNLMGQVFYVLQDWWLSHWANRQGALNDTKNANGNVTGTLDLSWY 764

  Fly   753 IYIFSGINAALVIFALLRTLLFFSMAMHSSTQLHNTMFQGVSRTALYFFHANP------------ 805
            :.|::|:.|..|:|.:.|:||.|.:.:::|..|||.||:.:.:..:.||..||
  Rat   765 LGIYTGLTAVTVLFGIARSLLVFYVLVNASQTLHNRMFESILKAPVLFFDRNPIELTQLEVFRVV 829

  Fly   806 ---------------------------------------------SGRILNRFAMDLGQVDEILP 825
                                                         .|||||||:.|:|.:|::||
  Rat   830 DGALDSHRHLSHPHPWPQNGSLQASVTSVTGSDVIRFPEVLLLALPGRILNRFSKDIGHMDDLLP 894

  Fly   826 AVMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYS 890
            ...||.||..|.:..:|.|.....||.||..:.:.:.|..||.::|.||||:||||:..|||::|
  Rat   895 LTFLDFIQTLLLVVSVIAVAAAVIPWILIPLVPLSIIFVVLRRYFLETSRDVKRLESTTRSPVFS 959

  Fly   891 HFSATLNGLSTIRAMEAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMS 955
            |.|::|.||.||||.:|::...:.:|.:||:||..::.||:|:|.|...||..|..:||.|...|
  Rat   960 HLSSSLQGLWTIRAYKAEERCQELFDAHQDLHSEAWFLFLTTSRWFAVRLDAICAVFVIVVAFGS 1024

  Fly   956 YFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESPDDKK 1020
            .......:.||:||.::.::::.|..||.:|||||:||.|.|||||:||..||.|..:|.  .|:
  Rat  1025 LVLAKTLDAGQVGLALSYSLTLMGMFQWSVRQSAEVENMMISVERVIEYTDLEKEAPWEC--RKR 1087

  Fly  1021 PPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFRLSY 1085
            ||..||.||:|..:.::..|:.|  ...|||.|..:|..|||:||||||||||||||:||||||.
  Rat  1088 PPPGWPHEGVIVFDNVNFTYSLD--GPLVLKHLTALIKSREKVGIVGRTGAGKSSLISALFRLSE 1150

  Fly  1086 NEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVHLKDE 1150
            .||.:.||......|||||||.|:||||||||||:||:|.|||||.:::||:||:|||||.||:.
  Rat  1151 PEGKIWIDKILTTEIGLHDLRKKMSIIPQEPVLFTGTMRKNLDPFNEHSDEELWKALEEVQLKEA 1215

  Fly  1151 VSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTIRRKF 1215
            :.:||..:::.:||.|||:|||||||||||||||::||||::|||||||||:||.|||..||.||
  Rat  1216 IEDLPGKMDTELAESGSNFSVGQRQLVCLARAILKKNRILIIDEATANVDPRTDELIQQKIREKF 1280

  Fly  1216 RDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTGRSSFEHLLKL 1280
            ..|||||||||||||||||::||||:|.|.|:..|:.|| |:...:||.||.|.|:.....|.:.
  Rat  1281 AQCTVLTIAHRLNTIIDSDKIMVLDSGRLREYDEPYVLL-QNPESLFYKMVQQLGKGEAAALTET 1344

  Fly  1281 ALEAHERR 1288
            |.:.:.||
  Rat  1345 AKQVYFRR 1352

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	572/1339 (43%)
		ABC_membrane	92..362	CDD:294371	109/277 (39%)
		ABCC_MRP_domain1	412..611	CDD:213217	108/199 (54%)
		ABC_membrane	718..981	CDD:294371	99/334 (30%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	141/220 (64%)
Abcc4	XP_038948894.1	MRP_assoc_pro	6..1334	CDD:188098	578/1353 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345054
Domainoid	1	1.000	229	1.000	Domainoid score	I2384
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H74563
Inparanoid	1	1.050	1102	1.000	Inparanoid score	I217
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	1	1.000	-	-		FOG0001028
OrthoInspector	1	1.000	-	-		otm44390
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	1	1.100	-	-	O	PTHR24223
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X771
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	14	13.810