DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9270 and Abcc3

DIOPT Version :9

Sequence 1:	NP_995741.2	Gene:	CG9270 / 35366	FlyBaseID:	FBgn0032908	Length:	1292	Species:	Drosophila melanogaster
Sequence 2:	NP_542148.2	Gene:	Abcc3 / 140668	RGDID:	71101	Length:	1523	Species:	Rattus norvegicus

Alignment Length:	1359	Identity:	469/1359 - (34%)
Similarity:	736/1359 - (54%)	Gaps:	129/1359 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KKLQTN--PRESAGIFSTLMFCFALPILFKGRKKTLEPTDLYNALKEHKAETLGDKFFATWQS-- 64
            :.|.||  |..|||.||.|.|.:...:...|.::.||.:||::..:|..:..:..:....||.
  Rat   200 ENLDTNPCPEASAGFFSRLSFWWFTKLAILGYRRPLEDSDLWSLSEEDCSHKVVQRLLEAWQKQQ 264

  Fly    65 -----------EVRSCGDS-------PK-KEPSIIRVILKVFGWQLFLSGIVVGVLELGTRATLP 110
                       |.:..|:.       || |:||.:|.:::.|...|.:......:.:|.:... |
  Rat   265 TQASGPQTAALEPKIAGEDEVLLKARPKTKKPSFLRALVRTFTSSLLMGACFKLIQDLLSFIN-P 328

  Fly   111 LILGALIAEFTRNGNGDGLWAQIYGLTLILSILFSVLMFHPLMMGLMHLAMKMRVAVSTAIYRKA 175
            .:|..|| .|..:......|..:....:.:|.....|:.|.....:..:|:::|.|:...|||||
  Rat   329 QLLSILI-RFISDPTAPTWWGFLLAGLMFVSSTMQTLILHQHYHCIFVMALRIRTAIIGVIYRKA 392

  Fly   176 LRLSRTALGDTTTGQVVNLISNDLGRFDRALIHFHFLWLGPLELLISSYFLYQQIGVASLYGIVI 240
            |.::.:...:.|.|::|||:|.|..||.......:.||..||:::::.|||:|.:|.::|.|:.:
  Rat   393 LTITNSVKREYTVGEMVNLMSVDAQRFMDVSPFINLLWSAPLQVILAIYFLWQILGPSALAGVAV 457

  Fly   241 LLLFLPIQTFLSRLTSRLRHQTALRTDQRVRMMNEIISGIQVIKMYTWEKPFGRLIERLRRSEMS 305
            ::|.:|:...:|......:.|.....|.|:::|:||::||:|:|:|.||..|...:|.:|:||:.
  Rat   458 IVLLIPLNGAVSMKMKTYQVQQMKFKDSRIKLMSEILNGIKVLKLYAWEPTFLEQVEGIRQSELQ 522

  Fly   306 SIRKVNYIRG------TLLSFEITLSRIAIFVSLLGFVLMGGELTAERAFSVTAFYNILRRTVCK 364
            .:||..|::.      ....|.:||..:.::|.    |.....|.||:||...:.:|||:..: .
  Rat   523 LLRKGAYLQAISTFIWVCTPFMVTLITLGVYVC----VDKNNVLDAEKAFVSLSLFNILKIPL-N 582

  Fly   365 FFPSGMSQFAEMMVTLRRIKGFMMRSETEALYLKGGQTNKLFEGEPLVKLQSFQARWNHDHVEPV 429
            ..|..:|...:..|:|:||:.|:.:.|.:...::    .|.......:.:.:....|:.| :.|.
  Rat   583 LLPQLISGMTQTSVSLKRIQDFLNQDELDPQCVE----RKTISPGRAITIHNGTFSWSKD-LPPT 642

  Fly   430 LENINISLSPPQLVAVIGPVGSGKSSLIQAILGELPGESGKLKVQGDISYASQEPWLFNASVRDN 494
            |.::||.:....||||:||||.|||||:.|:|||:....|.:.|:|.::|..|:.|:.|.::::|
  Rat   643 LHSLNIQIPKGALVAVVGPVGCGKSSLVSALLGEMEKLEGAVSVKGSVAYVPQQAWIQNCTLQEN 707

  Fly   495 ILFGLPMDKHRYRNVIRNCALERDFELL-HGDRTFVGERGASLSGGQRARISLARAVYRQADTYL 558
            :|||.||:..||:..:..|||..|.::| .||:|.:||:|.:||||||.|:|||||||..|:.:|
  Rat   708 VLFGQPMNPKRYQQALETCALLADLDVLPGGDQTEIGEKGINLSGGQRQRVSLARAVYSDANIFL 772

  Fly   559 LDDPLSAVDTHVGRHLFEECM--RGFLRDKLVILVTHQLQFLEHADLIVIMDKGKISAVGTYEEM 621
            |||||||||:||.:|:|::.:  .|.|..|..:||||.:.||...|.|:::..|:|:.:|.|.|:
  Rat   773 LDDPLSAVDSHVAKHIFDQVIGPEGVLAGKTRVLVTHGISFLPQTDFIIVLADGQITEMGHYSEL 837

  Fly   622 LKSGQDFGKLLATEAQEMGDSNQE----------------------------------------- 645
            |:....|...|...|.   |.|||
  Rat   838 LQHDGSFANFLRNYAP---DENQEANEGVLQHANEEVLLLEDTLSTHTDLTDTEPAIYEVRKQFM 899

  Fly   646 ----QVNAEGDSRNDKSTYSRQSSRVSRVSVTSVDSSTESILDNERQPAQESRSQGKIGLGIYGK 706
                .:::||:.:| :....|.:|.:.:....:....|.:::      .:|....|.:.|.:|..
  Rat   900 REMSSLSSEGEGQN-RPVLKRYTSSLEKEVPATQTKETGALI------KEEIAETGNVKLSVYWD 957

  Fly   707 YFSAGSGWLMVILVAFFCL---GTQILASGGDYFLSYW---VKNNDSSSSTDIYIFSGINAAL-V 764
            |  |.|..|...|  |.||   |...:|.|.:.:||.|   |:.:...::|.:.:  |:.|.| :
  Rat   958 Y--AKSVGLCTTL--FICLLYAGQNAVAIGANVWLSAWTNDVEEHGQQNNTSVRL--GVYATLGI 1016

  Fly   765 IFALLRTLLFFSM---AMHSSTQLHNTMFQGVSRTALYFFHANPSGRILNRFAMDLGQVDEILPA 826
            :..||..|..|:|   |:.::..||..:.....|....||...|||||||||:.|:..:||:|..
  Rat  1017 LQGLLVMLSAFTMVVGAIQAARLLHTALLHNQIRAPQSFFDTTPSGRILNRFSKDIYVIDEVLAP 1081

  Fly   827 VMLDCIQIFLTISGIIGVLCITNPWYLINTITMFLAFHFLRTFYLSTSRDLKRLEAIARSPMYSH 891
            .:|.....|.|....|.|:..:.|.:.:..:.:.:.:.|::.||::|||.|||||:::|||::||
  Rat  1082 TILMLFNSFYTSISTIVVIVASTPLFCVVVLPLAVFYGFVQRFYVATSRQLKRLESVSRSPIFSH 1146

  Fly   892 FSATLNGLSTIRAM-EAQDLLTKEYDNYQDIHSSGYYTFLSTNRAFGYYLDLFCVAYVISVTLMS 955
            ||.|:.|.|.|||. ..||..... |...|.:....|.::::||..|.:::......|:...|.:
  Rat  1147 FSETVTGTSVIRAYGRVQDFKVLS-DAKVDSNQKTTYPYIASNRWLGVHVEFVGNCVVLFSALFA 1210

  Fly   956 YFNPPVDNPGQIGLVITQAMSMTGTVQWGMRQSAELENSMTSVERVLEYRHLEAEGEFESP---D 1017
            .......|||.:||.::.|:.:|.::.|.:|..::||:::.:||||.||    ::.|.|:|   :
  Rat  1211 VIGRNSLNPGLVGLSVSYALQVTLSLNWMIRTLSDLESNIIAVERVKEY----SKTETEAPWVLE 1271

  Fly  1018 DKKPPMNWPQEGLISAEQLSLRYNPDPKADRVLKSLNFIIMPREKIGIVGRTGAGKSSLINALFR 1082
            ..:.|..||:.|::.....|:||.|.  .:.|||:|...:...||:||||||||||||:...|||
  Rat  1272 SNRAPEGWPRSGVVEFRNYSVRYRPG--LELVLKNLTLHVQGGEKVGIVGRTGAGKSSMTLCLFR 1334

  Fly  1083 -LSYNEGSLVIDNTDILGIGLHDLRSKISIIPQEPVLFSGTLRCNLDPFEQYADEKLWEALEEVH 1146
             |...||.:.||..::..||||||||:::||||:|:|||||||.|||||.:|:||.:|..||..|
  Rat  1335 ILEAAEGEIFIDGLNVAHIGLHDLRSQLTIIPQDPILFSGTLRMNLDPFGRYSDEDIWRTLELSH 1399

  Fly  1147 LKDEVSELPNGLESVVAEGGSNYSVGQRQLVCLARAILRENRILVMDEATANVDPQTDALIQSTI 1211
            |...||..|.||:...:|||.|.|||||||||||||:||::|:||:|||||.:|.:||.|||.||
  Rat  1400 LSAFVSSQPTGLDFQCSEGGDNLSVGQRQLVCLARALLRKSRVLVLDEATAAIDLETDDLIQGTI 1464

  Fly  1212 RRKFRDCTVLTIAHRLNTIIDSDRVMVLDAGTLVEFGSPFELLTQSWSKVFYGMVLQTG 1270
            |.:|.||||||||||||||:|.:||:|||.|.:.||.||..|:..  ..:||||....|
  Rat  1465 RTQFEDCTVLTIAHRLNTIMDYNRVLVLDKGVVAEFDSPVNLIAA--GGIFYGMAKDAG 1521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9270	NP_995741.2	CFTR_protein	6..1257	CDD:273530	464/1342 (35%)
		ABC_membrane	92..362	CDD:294371	76/275 (28%)
		ABCC_MRP_domain1	412..611	CDD:213217	89/201 (44%)
		ABC_membrane	718..981	CDD:294371	86/273 (32%)
		ABCC_MRP_domain2	1029..1250	CDD:213211	129/221 (58%)
Abcc3	NP_542148.2	MRP_assoc_pro	7..1522	CDD:188098	469/1359 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345004
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0054
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG51855
OrthoDB	1	1.010	-	-		D138195at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100026
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.660